tnpo1
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  • Official Full Name
  • transportin 1
  • Background
  • This gene encodes the beta subunit of the karyopherin receptor complex which interacts with nuclear localization signals to target nuclear proteins to the nucleus. The karyopherin receptor complex is a heterodimer of an alpha subunit which recognizes the nuclear localization signal and a beta subunit which docks the complex at nucleoporins. Alternate splicing of this gene results in two transcript variants encoding different proteins. [provided by RefSeq, Jul 2008]
  • Synonyms
  • TNPO1; transportin 1; MIP; TRN; IPO2; MIP1; KPNB2; transportin-1; importin 2; importin beta 2; importin beta-2; karyopherin beta-2; M9 region interaction protein; karyopherin (importin) beta 2;
Cat.#:TNPO1-31605THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human TNPO1
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Cat.#:TNPO1-342HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TNPO1 Protein, His-tagged
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Cat.#:TNPO1-17203MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse TNPO1 Protein
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Cat.#:Tnpo1-343MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Tnpo1 Protein, His-tagged
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Cat.#:TNPO1-341CTag:His
Source (Host):E. coliSpecies:Cattle
Product nameRecombinant Cattle TNPO1 Protein, His-tagged
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Involved Pathway

TNPO1 involved in several pathways and played different roles in them. We selected most pathways TNPO1 participated on our site, such as Assembly of the primary cilium, Gene Expression, Intraflagellar transport, which may be useful for your reference. Also, other proteins which involved in the same pathway with TNPO1 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Assembly of the primary cilium
SDCCAG8; UNC119.1; FBF1; TTC30A2; IFT172; RPGRIP1L; KIF3B; TNPO1; UNC119B; NINL
Gene Expression
ZFP36L1; ZNF643; ZNF726; ZNF554; IPO8; RDBP; NT5C3B; ZNF671; NR2C2AP; RARAB
Intraflagellar transport
DYF-1; DYNLL2B; TRIP11; WDR19; IFT20; HSPB11; TTC30A1; KIFAP3A; IFT-20; TTC26
Organelle biogenesis and maintenance
KIF3CB; PPRC1; TTC30A2; BBS4; WDR19; TRIP11; TCTN1; MARK4; TRAF3IP1; EXOC5
Regulation of mRNA stability by proteins that bind AU-rich elements
ZFP36L1B; ZFP36L1; ANP32A; ELAVL1; SETB; ZFP36L1A; SETA; HUG; KHSRP; TNPO1
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA
TNPO1

Protein Function

TNPO1 has several biochemical functions, for example, Ran GTPase binding, nuclear localization sequence binding, poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TNPO1 itself. We selected most functions TNPO1 had, and list some proteins which have the same functions with TNPO1. You can find most of the proteins on our site.
Function
Related Protein
Function Ran GTPase binding
Related Protein NXT1; RANBP1; RANBP10; XPOT; TNPO1; XPO5; RANBP2; NUTF2; XPO4; CSE1L
Function nuclear localization sequence binding
Related Protein BRAP; KPNA5; KPNA7; NFKBIA; TNPO2; TNPO3; KPNA1; KPNA6; NUP214; IPO5
Function poly(A) RNA binding
Related Protein DDX39B; HIST1H1C; DZIP3; KPNB1; FKBP3; SSB; CDK11B; ETF1; MRPL10; TIA1
Function protein binding
Related Protein MAP2; CYBB; CLNS1A; ARHGDIA; WDR25; VAMP3; ANXA7; PTK2; XAB2; BNIPL
Function protein transporter activity
Related Protein TIMM10; VPS26B; FRAG1; TNPO1; KPNB3; TNPO2; RUFY1; XPO1; RANBP6; RAMP2

Interacting Protein

TNPO1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TNPO1 here. Most of them are supplied by our site. Hope this information will be useful for your research of TNPO1.
RAN; NXF1; LRRK2; L1; L2; E6; L1; L1; ACTB; GRB2; YWHAZ; glsA2; 1-phosphatidyl-1d-myo-inositol 3,5-bisphosphate; 1-phosphatidyl-1d-myo-inositol 4,5-bisphosphate; 15-deoxy-delta(12,14; midostaurin