TNPO1
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Official Full Name
transportin 1
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Overview
This gene encodes the beta subunit of the karyopherin receptor complex which interacts with nuclear localization signals to target nuclear proteins to the nucleus. The karyopherin receptor complex is a heterodimer of an alpha subunit which recognizes the nuclear localization signal and a beta subunit which docks the complex at nucleoporins. Alternate splicing of this gene results in two transcript variants encoding different proteins. [provided by RefSeq, Jul 2008] -
Synonyms
TNPO1; transportin 1; MIP; TRN; IPO2; MIP1; KPNB2; transportin-1; importin 2; importin beta 2; importin beta-2; karyopherin beta-2; M9 region interaction protein; karyopherin (importin) beta 2;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Cattle
- Human
- Mouse
- E.coli
- HEK293
- Mammalian Cell
- Wheat Germ
- His
- His (Fc)
- Avi
- N/A
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
---|---|---|---|---|---|---|
Human | TNPO1-31605TH | Recombinant Human TNPO1 | Wheat Germ | N/A | 117 amino acids | |
Human | TNPO1-342H | Recombinant Human TNPO1 Protein, His-tagged | E.coli | His | Lys626~Val836 | |
Mouse | Tnpo1-343M | Recombinant Mouse Tnpo1 Protein, His-tagged | E.coli | His | Cys597~Ile837 | |
Mouse | TNPO1-17203M | Recombinant Mouse TNPO1 Protein | Mammalian Cell | His | ||
Mouse | TNPO1-9503M | Recombinant Mouse TNPO1 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Mouse | TNPO1-9503M-B | Recombinant Mouse TNPO1 Protein Pre-coupled Magnetic Beads | HEK293 | |||
Cattle | TNPO1-341C | Recombinant Cattle TNPO1 Protein, His-tagged | E.coli | His | Pro593~Val836 |
- Involved Pathway
- Protein Function
- Interacting Protein
TNPO1 involved in several pathways and played different roles in them. We selected most pathways TNPO1 participated on our site, such as Assembly of the primary cilium, Gene Expression, Intraflagellar transport, which may be useful for your reference. Also, other proteins which involved in the same pathway with TNPO1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Assembly of the primary cilium | CCT3;KIF3CB;IQCB1;CNGA5;SSNA1;DYNLL2B;CLUAP1;ODF2B;NEK2 |
Gene Expression | GTF3C5;TAF1D;TRMT61A;POLR3F;ZNF773;C2orf29;ZNF750;EIF1AXA;CSTF2 |
Intraflagellar transport | WDR34;DYNLRB2;IFT27;DYNLL2;IFT81;CLUAP1;FLR;KIF3CB;IFT46 |
Organelle biogenesis and maintenance | TCTN3;LZTFL1;MTIF3;RABL5;MKKS;MRPL40;KIFAP3B;BBS9;KIFAP3A |
Regulation of mRNA stability by proteins that bind AU-rich elements | SETB;ZFP36L1B;HUG;ZFP36L1A;KHSRP;SETA;SET;ZFP36L1;ANP32A |
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA |
TNPO1 has several biochemical functions, for example, Ran GTPase binding, nuclear localization sequence binding, poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TNPO1 itself. We selected most functions TNPO1 had, and list some proteins which have the same functions with TNPO1. You can find most of the proteins on our site.
Function | Related Protein |
---|---|
Ran GTPase binding | XPO1;TNPO2;NXT1;XPO5;DPY19L2;XPO7;IPO9;KPNB1;IPO13 |
nuclear localization sequence binding | TNPO2;KPNA5;IPO13;KPNB1;KPNA7;KPNA1;IPO4;NUP214;KPNB3 |
poly(A) RNA binding | DYNC1LI1;SKIV2L2;HNRPLL;TRA2B;SURF6;HEATR6;PCSK9;HSP90AA1;NOSIP |
protein binding | FBXO27;APBB1IP;NDC80;PPP1R15A;PTPMT1;SLC25A5;SETDB1;AIMP2;BARHL2 |
protein transporter activity | AP3S1;RAMP3;IPO5;XPO1;IPO4;AP1S3B;KPNA5;AP2B1;KPNA1 |
TNPO1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TNPO1 here. Most of them are supplied by our site. Hope this information will be useful for your research of TNPO1.
RAN; NXF1; LRRK2; L1; L2; E6; L1; L1; ACTB; GRB2; YWHAZ; glsA2; 1-phosphatidyl-1d-myo-inositol 3,5-bisphosphate; 1-phosphatidyl-1d-myo-inositol 4,5-bisphosphate; 15-deoxy-delta(12,14; midostaurin
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