traf4
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  • Official Full Name
  • TNF receptor-associated factor 4
  • Background
  • This gene encodes a member of the TNF receptor associated factor (TRAF) family. TRAF proteins are associated with, and mediate signal transduction from members of the TNF receptor superfamily. The encoded protein has been shown to interact with neurotrophin receptor, p75 (NTR/NTSR1), and negatively regulate NTR induced cell death and NF-kappa B activation. This protein has been found to bind to p47phox, a cytosolic regulatory factor included in a multi-protein complex known as NAD(P)H oxidase. This protein thus, is thought to be involved in the oxidative activation of MAPK8/JNK. Alternatively spliced transcript variants have been observed but the full-length nature of only one has been determined.
  • Synonyms
  • TRAF4; TNF receptor-associated factor 4; CART1; MLN62; RNF83; MLN 62; malignant 62; RING finger protein 83; metastatic lymph node gene 62 protein; tumor necrosis receptor-associated factor 4A; cysteine-rich domain associated with ring and TRAF domain; cys
Cat.#:TRAF4-558HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TRAF4 Protein, His-tagged
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Cat.#:TRAF4-31602THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TRAF4, His-tagged
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Cat.#:TRAF4-3387HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TRAF4, GST-tagged
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Cat.#:TRAF4-550HTag:GST/His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TRAF4 Protein, GST-His-tagged
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Cat.#:TRAF4-17289MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse TRAF4 Protein
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Cat.#:TRAF4-820HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human TRAF4 293 Cell Lysate
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Involved Pathway

TRAF4 involved in several pathways and played different roles in them. We selected most pathways TRAF4 participated on our site, such as Pathways in cancer, Small cell lung cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with TRAF4 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Pathways in cancer
APC2; SUFU; GSK3B; FZD10; PIK3CG; RASSF1; FADD; HRAS; SFPI1; FZD7
Small cell lung cancer
NFKBIA; COL4A1; ITGAV; XIAP; IKBKB; ITGA2B; PIK3R5; BIRC2; PTEN; AKT2

Protein Function

TRAF4 has several biochemical functions, for example, DNA binding, WW domain binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TRAF4 itself. We selected most functions TRAF4 had, and list some proteins which have the same functions with TRAF4. You can find most of the proteins on our site.
Function
Related Protein
Function DNA binding
Related Protein SET; HIST1H4L; RFX8; RARAA; TAF15; ARID4A; IGHMBP2; IER2; H2AFB2; ONECUT1
Function WW domain binding
Related Protein TCEAL8; TCEAL6; TMEM128; WBP1; DAZAP2; NDFIP2; TCEAL7; WBP11; TCEAL3; TCEAL2
Function protein binding
Related Protein FANCL; GSG2; CAMK2B; ABTB1; TOR1AIP1; PDIK1L; FH; PICK1; APOBEC1; ITK
Function protein kinase binding
Related Protein NIPAL1; SLC12A5; IBTK; KIF14; CRY1; CD3E; PRDX3; NME2; STK39; PKD1
Function thioesterase binding
Related Protein CALM1; ADRA2A; RAC1; TRAF3; CALM3; CALM; TRAF6; TRAF1; HAUS7; TRAF5
Function tumor necrosis factor receptor binding
Related Protein TRADD; LTA; TNFSF10; CD40LG; TRAF2; TRAF4; Fasl; TNFSF12; FADD; ERAP1
Function ubiquitin protein ligase binding
Related Protein CUL1B; AURKA; CUL1; SMAD2; UBE2K; CHEK2; TRIM37; CUL3; GABARAPL1; BCL10
Function ubiquitin-protein transferase activity
Related Protein MUL1B; FEM1B; UBE2L6; ANAPC4; XIAP; PJA2; RAG1; RNF181; RNF141; UBE2E3
Function zinc ion binding
Related Protein PIAS4A; GLI2; MARCH8; KDM5D; RNF11A; PPARA; USP45; ZNRF2; RYBP; CAPNS2

Interacting Protein

TRAF4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TRAF4 here. Most of them are supplied by our site. Hope this information will be useful for your research of TRAF4.
WWP2; BYSL; SMURF1; BCL6B; NPIPA7