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TRAF4

  • Official Full Name

    TNF receptor-associated factor 4

  • Overview

    This gene encodes a member of the TNF receptor associated factor (TRAF) family. TRAF proteins are associated with, and mediate signal transduction from members of the TNF receptor superfamily. The encoded protein has been shown to interact with neurotrophin receptor, p75 (NTR/NTSR1), and negatively regulate NTR induced cell death and NF-kappa B activation. This protein has been found to bind to p47phox, a cytosolic regulatory factor included in a multi-protein complex known as NAD(P)H oxidase. This protein thus, is thought to be involved in the oxidative activation of MAPK8/JNK. Alternatively spliced transcript variants have been observed but the full-length nature of only one has been determined.
  • Synonyms

    TRAF4; TNF receptor-associated factor 4; CART1; MLN62; RNF83; MLN 62; malignant 62; RING finger protein 83; metastatic lymph node gene 62 protein; tumor necrosis receptor-associated factor 4A; cysteine-rich domain associated with ring and TRAF domain; cys;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • E.coli
  • HEK293
  • Mammalian Cell
  • GST
  • GST|His
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human TRAF4-3387H Recombinant Human TRAF4, GST-tagged E.coli GST 35-307AA
Human TRAF4-550H Recombinant Human TRAF4 Protein, GST-His-tagged E.coli GST/His
Human TRAF4-31602TH Recombinant Human TRAF4, His-tagged E.coli His
Human TRAF4-820HCL Recombinant Human TRAF4 293 Cell Lysate HEK293 N/A
Human TRAF4-558H Recombinant Human TRAF4 Protein, His-tagged E.coli His Gln193~Asp444
Human TRAF4-6711H Recombinant Human TRAF4 Protein (Gln193-Asp444), His tagged E.coli His Gln193-Asp444
Mouse TRAF4-17289M Recombinant Mouse TRAF4 Protein Mammalian Cell His
Mouse TRAF4-9558M-B Recombinant Mouse TRAF4 Protein Pre-coupled Magnetic Beads HEK293
Mouse TRAF4-9558M Recombinant Mouse TRAF4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
  • Involved Pathway
  • Protein Function
  • Interacting Protein

TRAF4 involved in several pathways and played different roles in them. We selected most pathways TRAF4 participated on our site, such as Pathways in cancer, Small cell lung cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with TRAF4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Pathways in cancerRAF1;HSP90AB1;PIK3CA;BCR;FZD3;WNT10B;FN1;TFG;ARNT
Small cell lung cancerTRAF6;IKBKB;LAMC1;LAMA3;TP53;PIAS2;PIK3CG;TRAF4;BCL2L1

TRAF4 has several biochemical functions, for example, DNA binding, WW domain binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TRAF4 itself. We selected most functions TRAF4 had, and list some proteins which have the same functions with TRAF4. You can find most of the proteins on our site.

Function Related Protein
DNA bindingPOLG;ZNF45;TRIM16;KDM5B;HIF1AL2;MNDA;ZFP521;ETV5;NKX2.7
WW domain bindingPPARG;ATCAY;WBP1;PMEPA1;KIF20B;SCNN1B;WBP5;TCEAL7;SHISA5
protein bindingSNAP23;CLK3;TBX24;CTNNB1;ARNT;ECT2;ZCCHC11;REXO1L1;BAZ2A
protein kinase bindingNSF;JTB;TRIM22;AP1B1;CD226;ZBTB4;E2F1;CALM;ZC3HC1
thioesterase bindingCDC42;TRAF2;ARF6;TRAF1;HAUS7;TRAF3;CALM3;TRAF5;TRAF4
tumor necrosis factor receptor bindingTRADD;Fasl;TRIM37;LTA;TNFSF12;TNFSF10L3;TNFSF13;TNFSF8;EDA
ubiquitin protein ligase bindingNFKBIA;GPI;RIPK1;BCL2;CUL3;TPI1;RAD18;EIF4E2;STUB1
ubiquitin-protein transferase activityG2E3;UBE2S;RNF151;TRAF4B;UBR3;TRIM2;TRAF5;TRAF7;ZNF738
zinc ion bindingZDHHC17;MT1E;PCGF1;PHC2;PRKCBB;PHF17;KIAA0913;SETDB1B;KAT6B

TRAF4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TRAF4 here. Most of them are supplied by our site. Hope this information will be useful for your research of TRAF4.

WWP2; BYSL; SMURF1; BCL6B; NPIPA7

  • Q&As
  • Reviews

Q&As (5)

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What are the potential clinical applications of TRAF4 protein in cancer treatment? 07/04/2022

TRAF4 may serve as a biomarker for certain types of cancer, and targeting TRAF4 signaling pathways could be a potential strategy for cancer therapy.

How does TRAF4 protein contribute to inflammation and autoimmune diseases? 02/15/2020

TRAF4 is involved in signaling pathways that regulate immune responses, and its dysregulation has been linked to inflammatory and autoimmune conditions.

Are there any current clinical trials or studies investigating TRAF4 protein in the context of autoimmune diseases? 12/11/2019

Several research studies are exploring the role of TRAF4 in autoimmune diseases, with the goal of identifying potential therapeutic targets.

How is TRAF4 protein involved in cancer? 08/29/2018

TRAF4 has been implicated in promoting the growth and metastasis of certain types of cancer, including breast and prostate cancer.

Can TRAF4 protein be used as a diagnostic marker for cancer? 05/21/2016

Research suggests that TRAF4 expression levels may be used as a diagnostic marker for certain types of cancer, aiding in early detection and prognosis.

Customer Reviews (3)

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Reviews
11/09/2022

    They have a deep understanding of the TRAF4 protein and can provide valuable insights into its characteristics, properties, and optimal experimental conditions.

    03/12/2022

      This guidance can help researchers design and execute their experiments more effectively, ensuring reliable and accurate results.

      01/21/2020

        the manufacturer offers outstanding technical support, serving as a valuable resource to resolve any issues that may arise during my research.

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