Recombinant Human TRAF4 Protein, GST-His-tagged

• Cat.No.: TRAF4-550H
• Product Overview: Recombinant Human TRAF4 fused with N-terminal GST and C-terminal His was expressed in E. coli.

Specification

• Description: This gene encodes a member of the TNF receptor associated factor (TRAF) family. TRAF proteins are associated with, and mediate signal transduction from members of the TNF receptor superfamily. The encoded protein has been shown to interact with neurotrophin receptor, p75 (NTR/NTSR1), and negatively regulate NTR induced cell death and NF-kappa B activation. This protein has been found to bind to p47phox, a cytosolic regulatory factor included in a multi-protein complex known as NAD(P)H oxidase. This protein thus, is thought to be involved in the oxidative activation of MAPK8/JNK. Alternatively spliced transcript variants have been observed but the full-length nature of only one has been determined. [
• Source: E. coli
• Tag: GST-His
• Form: 25mM Tris, pH8.0, 150mM NaCl, 10% glycerol, 1%Sarkosyl.
• Molecular Mass: 81.4 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: >50 ug/mL as determined by microplate BCA method

Gene Information

• Gene Name: TRAF4 TNF receptor-associated factor 4 [ Homo sapiens ]
• Official Symbol: TRAF4
• Synonyms: TRAF4; TNF receptor-associated factor 4; CART1; MLN62; RNF83; MLN 62; malignant 62; RING finger protein 83; metastatic lymph node gene 62 protein; tumor necrosis receptor-associated factor 4A; cysteine-rich domain associated with ring and TRAF domain; cysteine-rich domain associated with RING and Traf domains protein 1
• Gene ID: 9618
• mRNA Refseq: NM_004295
• Protein Refseq: NP_004286
• MIM: 602464
• UniProt ID: Q9BUZ4