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WFS1

  • Official Full Name

    Wolfram syndrome 1 (wolframin)

  • Overview

    Wolfram syndrome protein (WFS1) is an 890 amino acid protein that contains a cytoplasmic N-terminal domain, followed by nine-transmembrane domains and a luminal C-terminal domain. WFS1 is predominantly localized to the endoplasmic reticulum (ER) and its
  • Synonyms

    WFS1; Wolfram syndrome 1 (wolframin); DFNA6, DFNA14, DFNA38; wolframin; DIDMOAD; WFS; WFRS; WFSL; FLJ51211;

  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Recombinant Proteins
  • Human
  • Mouse
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Mammalian cells
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human WFS1-316HCL Recombinant Human WFS1 293 Cell Lysate HEK293 N/A
Human WFS1-2357H-B Recombinant Human WFS1 Protein Pre-coupled Magnetic Beads HEK293
Human WFS1-3646H Recombinant Human WFS1 protein, GST-tagged E.coli GST 1-95 aa
Human WFS1-3288H Recombinant Human WFS1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human WFS1-577H Recombinant Human WFS1 Protein, His-tagged E.coli N-His Met1-Lys300
Human WFS1-6412H Recombinant Human WFS1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human WFS1-852HFL Recombinant Full Length Human WFS1 Protein, C-Flag-tagged Mammalian cells Flag
Human WFS1-2357H Recombinant Human WFS1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse WFS1-18542M Recombinant Mouse WFS1 Protein Mammalian Cell His
Mouse Wfs1-6999M Recombinant Mouse Wfs1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse WFS1-10174M Recombinant Mouse WFS1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse WFS1-10174M-B Recombinant Mouse WFS1 Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • WFS1 Related Articles
  • WFS1 Related Research Area

WFS1 involved in several pathways and played different roles in them. We selected most pathways WFS1 participated on our site, such as Protein processing in endoplasmic reticulum, which may be useful for your reference. Also, other proteins which involved in the same pathway with WFS1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Protein processing in endoplasmic reticulumEIF2AK2;CUL1;PDIA6;DNAJC3A;RAD23B;CALRL2;HSPA5;RNF5;UBE2G1

WFS1 has several biochemical functions, for example, ATPase binding, protein binding, ubiquitin protein ligase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by WFS1 itself. We selected most functions WFS1 had, and list some proteins which have the same functions with WFS1. You can find most of the proteins on our site.

Function Related Protein
ATPase bindingRALB;PEX19;DNAJC10;SLN;SELS;ATP6V0A1A;DNAJB1;DERL1;USP25
protein bindingPTPRG;CCDC47;ETL4;CARKD;LRR1;TRIM74;ADAM33;BTBD1;SIX3
ubiquitin protein ligase bindingUBE2U;CUL3A;RPA2;UBE2NA;SQSTM1;HSPD1;RNF31;UBE2K;ABI2

WFS1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with WFS1 here. Most of them are supplied by our site. Hope this information will be useful for your research of WFS1.

TERF1; ITGB3BP; MAPK6; CFTR

Boettcher, C; Brosig, B; et al. The subtle signs of Wolfram (DIDMOAD) syndrome: not all juvenile diabetes is type 1 diabetes. JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM 24:71-74(2011).
Xu, R; Xia, B; et al. Expression and localization of Wolfram syndrome 1 gene in the developing rat pancreas. WORLD JOURNAL OF GASTROENTEROLOGY 15:5425-5431(2009).
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