ABCG8
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Official Full Name
ATP-binding cassette, sub-family G (WHITE), member 8
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Overview
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. The protein encoded by this gene functions to exclude non-cholesterol sterol entry at the intestinal level, promote excretion of cholesterol and sterols into bile, and to facilitate transport of sterols back into the intestinal lumen. It is expressed in a tissue-specific manner in the liver, intestine, and gallbladder. This gene is tandemly arrayed on chromosome 2, in a head-to-head orientation with family member ABCG5. Mutations in this gene may contribute to sterol accumulation and atherosclerosis, and have been observed in patients with sitosterolemia. -
Synonyms
ABCG8; ATP-binding cassette, sub-family G (WHITE), member 8; ATP binding cassette, sub family G (WHITE), member 8 (sterolin 2); ATP-binding cassette sub-family G member 8; gallbladder disease 4; GBD4; sterolin 2; sterolin-2; ATP-binding cassette, subfamil;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Arabidopsis thaliana (Mouse-ear cress)
- Dictyostelium discoideum (Slime mold)
- Homo sapiens (Human)
- Human
- Mouse
- Mus musculus (Mouse)
- Rat
- Rattus norvegicus (Rat)
- Zebrafish
- E.coli
- E.coli expression system
- E.Coli or Yeast
- HEK293
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- His|T7
- N/A
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | ABCG8-069H | Recombinant Human ABCG8 Protein | Wheat Germ | N/A |
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| Human | ABCG8-9141HCL | Recombinant Human ABCG8 293 Cell Lysate | HEK293 | N/A |
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| Human | ABCG8-822HF | Recombinant Full Length Human ABCG8 Protein | In Vitro Cell Free System | GST | 673 amino acids |
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| Mouse | ABCG8-1119M | Recombinant Mouse ABCG8 Protein | Mammalian Cell | His |
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| Mouse | Abcg8-8151M | Recombinant Mouse Abcg8 protein, His & T7-tagged | E.coli | His/T7 | Met1~Gln272 (Accession # Q9DBM0) |
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| Mouse | ABCG8-209M-B | Recombinant Mouse ABCG8 Protein Pre-coupled Magnetic Beads | HEK293 |
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| Mouse | ABCG8-209M | Recombinant Mouse ABCG8 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
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| Rat | Abcg8-8152R | Recombinant Rat Abcg8 protein, His & T7-tagged | E.coli | His/T7 | Met1~Gln271 (Accession # P58428) |
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| Rat | ABCG8-416R | Recombinant Rat ABCG8 Protein | Mammalian Cell | His |
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| Rat | Abcg8-3742R | Recombinant Rat Abcg8, His-tagged | E.Coli or Yeast | His | 672 |
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| Rat | ABCG8-71R | Recombinant Rat ABCG8 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
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| Rat | ABCG8-71R-B | Recombinant Rat ABCG8 Protein Pre-coupled Magnetic Beads | HEK293 |
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| Arabidopsis thaliana (Mouse-ear cress) | RFL12151AF | Recombinant Full Length Arabidopsis Thaliana Abc Transporter G Family Member 8(Abcg8) Protein, His-Tagged | E.coli expression system | His | Full Length (1-589) |
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| Dictyostelium discoideum (Slime mold) | RFL6175DF | Recombinant Full Length Dictyostelium Discoideum Abc Transporter G Family Member 8(Abcg8) Protein, His-Tagged | E.coli expression system | His | Full Length (1-626) |
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| Homo sapiens (Human) | RFL16259HF | Recombinant Full Length Human Atp-Binding Cassette Sub-Family G Member 8(Abcg8) Protein, His-Tagged | E.coli expression system | His | Full Length (1-673) |
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| Mus musculus (Mouse) | RFL27496MF | Recombinant Full Length Mouse Atp-Binding Cassette Sub-Family G Member 8(Abcg8) Protein, His-Tagged | E.coli expression system | His | Full Length (1-673) |
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| Rattus norvegicus (Rat) | RFL-18480RF | Recombinant Full Length Rat Atp-Binding Cassette Sub-Family G Member 8(Abcg8) Protein, His-Tagged | E.coli expression system | His | Full Length (1-694) |
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| Zebrafish | ABCG8-6439Z | Recombinant Zebrafish ABCG8 | Mammalian Cell | His |
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- Involved Pathway
- Protein Function
- Interacting Protein
- ABCG8 Related Articles
ABCG8 involved in several pathways and played different roles in them. We selected most pathways ABCG8 participated on our site, such as ABC transporters, Fat digestion and absorption, Bile secretion, which may be useful for your reference. Also, other proteins which involved in the same pathway with ABCG8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| ABC transporters | TAP1;ABCC2;ABCC9;ABCB6A;ABCA1B;ABCA4;ABCD3A;ABCB9;CFTR |
| Fat digestion and absorption | PLA2G5;ABCG8;APOA1;PNLIPRP2;PLA2G1B;FABP1;CLPS;MOGAT3;PLA2G12A |
| Bile secretion | CA2;SLCO1B2;CYP7A1;AQP4;ADCY7;HMGCR;SLC9A3;PRKACA;PRKACG |
ABCG8 has several biochemical functions, for example, contributes_to ATP binding, contributes_to ATPase activity, ATPase activity, coupled to transmembrane movement of substances. Some of the functions are cooperated with other proteins, some of the functions could acted by ABCG8 itself. We selected most functions ABCG8 had, and list some proteins which have the same functions with ABCG8. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| contributes_to ATP binding | MSH6;ATP1A2;MSH2;ATP5D;SFRP5;ATP1B1;ABCG8 |
| contributes_to ATPase activity | RUVBL2;ATP5J2;ATP5I;ATP5A1;ATP5H;ATP5L;MSH2;ABCA7;ATP5J |
| ATPase activity, coupled to transmembrane movement of substances | IPO8;ABCB1;ABCD1;ABCG3;ABCG2D;ABCB4;ABCA1;ABCA1B;ABCA13 |
| contributes_to cholesterol transporter activity | ABCG8;ABCG5;APOA2;APOA1;SFRP5 |
| protein binding | ZWILCH;PHF7;ALDH3B1;CCDC148;ARFRP1;NMRK1;TRIM71;SSSCA1;WDFY3 |
| protein heterodimerization activity | LIMK1;EFHA1;SUPT3H;BIK;PEF1;HIST1H2AM;BCL2A;P4HB;ENO2 |
ABCG8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ABCG8 here. Most of them are supplied by our site. Hope this information will be useful for your research of ABCG8.
ABCG5; AGPAT2; NUPR1; ANG; LMNB1; NR4A1; AKT2; MAL2
- Q&As
- Reviews
Q&As (10)
Ask a questionTo a lesser extent, NPC1L1 rs217434 variants increase the risk of early-onset gallstone formation.
Single nucleotide polymorphisms (SNPs) in ABCG8 transporter have been associated with hypercholesterolemia.
lt will cause extremely low biliary cholesterol concentrations while biliary phospholipids and bile acid concentrations are not altered.
Mice lacking leptin, exhibit decreased abundance of ABCG8 proteins in the liver.
It will potentially induce atherosclerosis because of reduced circulating and hepatic cholesterol.
both anti-ABCG5 and anti-ABCG8 antibodies bound to ~75 kDa proteins in human liver crude membranes.
One study constructed mouse models deficient in either Abcg5 or Abcg8 that show different biliary physiology than that of the Abcg5/Abcg8 double knockout mice. This suggests these proteins may have independent function(s) in addition to their function as heterodimers.
ABCG8 appear to line the brush border.
Disruptions of bile acid metabolism alter hepatic ABCG5/G8 expression.
ABCG5 and ABCG8 are co-regulated at the transcriptional level, sharing a common bidirectional promoter of 374 base pairs that separates their initiation codons, cause sitosterolemia as well.
Customer Reviews (2)
Write a reviewGood work in immunohistochemistry
The purification rsults demonstrtaed clearly! Great.
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