Recombinant Full Length Human ABCG8 Protein

• Cat.No.: ABCG8-822HF
• Product Overview: Human ABCG8 full-length ORF (ADR83246.1) recombinant protein without tag.

Specification

• Description: The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. The protein encoded by this gene functions to exclude non-cholesterol sterol entry at the intestinal level, promote excretion of cholesterol and sterols into bile, and to facilitate transport of sterols back into the intestinal lumen. It is expressed in a tissue-specific manner in the liver, intestine, and gallbladder. This gene is tandemly arrayed on chromosome 2, in a head-to-head orientation with family member ABCG5. Mutations in this gene may contribute to sterol accumulation and atherosclerosis, and have been observed in patients with sitosterolemia. [provided by RefSeq, Jul 2008]
• Source: In Vitro Cell Free System
• Species: Human
• Tag: GST
• Form: Liquid
• Molecular Mass: 74.1 kDa
• Protein Length: 673 amino acids
• AA Sequence: MAGKAAEERG LPKGATPQHT SGLQDRLFSS ESDNSLYFTY SGQPNTLEVR DLNYQVDLAS QVPWFEQLAQ FKMPWTSPSC QNSCELGIQN LSFKVRSGQM LAIIGSSGCG RASLLDVITG RGHGGKIKSG QIWINGQPSS PQLVRKCVAH VRQHNQLLPN LTVRETLAFI AQMRLPRTFS QAQRDKRVED VIAELRLRQC ADTRVGNMYV RGLSGGERRR VSIGVQLLWN PGILILDEPT SGLDSFTAHN LVKTLSRLAK GNRLVLISLH QPRSDIFRLF DLVLLMTSGT PIYLGAAQHM VQYFTAIGYP CPRYSNPADF YVDLTSIDRR SREQELATRE KAQSLAALFL EKVRDLDDFL WKAETKDLDE DTCVESSVTP LDTNCLPSPT KMPGAVQQFT TLIRRQISND FRDLPTLLIH GAEACLMSMT IGFLYFGHGS IQLSFMDTAA LLFMIGALIP FNVILDVISK CYSERAMLYY ELEDGLYTTG PYFFAKILGE LPEHCAYIII YGMPTYWLAN LRPGLQPFLL HFLLVWLVVF CCRIMALAAA ALLPTFHMAS FFSNALYNSF YLAGGFMINL SSLWTVPAWI SKVSFLRWCF EGLMKIQFSR RTYKMPLGNL TIAVSGDKIL SAMELDSYPL YAIYLIVIGL SGGFMVLYYV SLRFIKQKPS QDW
• Applications: Antibody Production
  Functional Study
  Compound Screening
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 25 mM Tris-HCl of pH8.0 containing 2% glycerol.

Gene Information

• Gene Name: ABCG8 ATP-binding cassette, sub-family G (WHITE), member 8 [ Homo sapiens ]
• Official Symbol: ABCG8
• Synonyms: ABCG8; ATP-binding cassette, sub-family G (WHITE), member 8; ATP binding cassette, sub family G (WHITE), member 8 (sterolin 2); ATP-binding cassette sub-family G member 8; gallbladder disease 4; GBD4; sterolin 2; sterolin-2; ATP-binding cassette, subfamily G, member 8; STSL; MGC142217
• Gene ID: 64241
• mRNA Refseq: NM_022437
• Protein Refseq: NP_071882
• MIM: 605460
• UniProt ID: Q9H221