Recombinant Human ABCG8 Protein

• Cat.No.: ABCG8-069H
• Product Overview: Human ABCG8 full-length ORF (ADR83246.1) recombinant protein without tag.

Specification

• Description: The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. The protein encoded by this gene functions to exclude non-cholesterol sterol entry at the intestinal level, promote excretion of cholesterol and sterols into bile, and to facilitate transport of sterols back into the intestinal lumen. It is expressed in a tissue-specific manner in the liver, intestine, and gallbladder. This gene is tandemly arrayed on chromosome 2, in a head-to-head orientation with family member ABCG5. Mutations in this gene may contribute to sterol accumulation and atherosclerosis, and have been observed in patients with sitosterolemia. [provided by RefSeq, Jul 2008]
• Source: Wheat Germ
• Species: Human
• Form: Liquid
• Molecular Mass: 74.1 kDa
• AA Sequence: MAGKAAEERGLPKGATPQHTSGLQD RLFSSESDNSLYFTYSGQPNTLEVR DLNYQVDLASQVPWFEQLAQFKMPW TSPSCQNSCELGIQNLSFKVRSGQM LAIIGSSGCGRASLLDVITGRGHGG KIKSGQIWINGQPSSPQLVRKCVAH VRQHNQLLPNLTVRETLAFIAQMRL PRTFSQAQRDKRVEDVIAELRLRQC ADTRVGNMYVRGLSGGERRRVSIGV QLLWNPGILILDEPTSGLDSFTAHN LVKTLSRLAKGNRLVLISLHQPRSD IFRLFDLVLLMTSGTPIYLGAAQHM VQYFTAIGYPCPRYSNPADFYVDLT SIDRRSREQELATREKAQSLAALFL EKVRDLDDFLWKAETKDLDEDTCVE SSVTPLDTNCLPSPTKMPGAVQQFT TLIRRQISNDFRDLPTLLIHGAEAC LMSMTIGFLYFGHGSIQLSFMDTAA LLFMIGALIPFNVILDVISKCYSER AMLYYELEDGLYTTGPYFFAKILGE LPEHCAYIIIYGMPTYWLANLRPGL QPFLLHFLLVWLVVFCCRIMALAAA ALLPTFHMASFFSNALYNSFYLAGG FMINLSSLWTVPAWISKVSFLRWCF EGLMKIQFSRRTYKMPLGNLTIAVS GDKILSAMELDSYPLYAIYLIVIGL SGGFMVLYYVSLRFIKQKPSQDW
• Applications: Antibody Production
  Functional Study
  Compound Screening
• Usage: Heating may cause protein aggregation. Please do not heat this product before electrophoresis.
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 25 mM Tris-HCl of pH8.0 containing 2% glycerol.

Gene Information

• Gene Name: ABCG8 ATP-binding cassette, sub-family G (WHITE), member 8 [ Homo sapiens ]
• Official Symbol: ABCG8
• Synonyms: ABCG8; ATP-binding cassette, sub-family G (WHITE), member 8; ATP binding cassette, sub family G (WHITE), member 8 (sterolin 2); ATP-binding cassette sub-family G member 8; gallbladder disease 4; GBD4; sterolin 2; sterolin-2; ATP-binding cassette, subfamily G, member 8; STSL; MGC142217
• Gene ID: 64241
• mRNA Refseq: NM_022437
• Protein Refseq: NP_071882
• MIM: 605460
• UniProt ID: Q9H221