alad
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  • Official Full Name
  • aminolevulinate dehydratase
  • Background
  • The ALAD enzyme is composed of 8 identical subunits and catalyzes the condensation of 2 molecules of delta-aminolevulinate to form porphobilinogen (a precursor of heme, cytochromes and other hemoproteins). ALAD catalyzes the second step in the porphyrin and heme biosynthetic pathway; zinc is essential for enzymatic activity. ALAD enzymatic activity is inhibited by lead and a defect in the ALAD structural gene can cause increased sensitivity to lead poisoning and acute hepatic porphyria.
  • Synonyms
  • ALAD; aminolevulinate dehydratase; aminolevulinate, delta , dehydratase; delta-aminolevulinic acid dehydratase; ALADH; PBGS; porphobilinogen synthase; MGC5057; OTTMUSP00000009377; RP11-10I9.1; ALADR; Delta aminolevulinic acid dehydratase; Lv; OTTMUSP00000009376; RP24-189G18.9; aminolevulinate, delta-, dehydratase
Cat.#:ALAD-512HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ALAD Protein, His-tagged
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Cat.#:Alad-513RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Alad Protein, His-tagged
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Cat.#:ALAD-26880THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ALAD, His-tagged
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Cat.#:ALAD-428HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human ALAD Protein, GST-tagged
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Cat.#:ALAD-1512MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse ALAD Protein
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Cat.#:ALAD-609RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat ALAD Protein
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Cat.#:ALAD-292CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus ALAD Protein, His-tagged
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Cat.#:ALAD-5496CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken ALAD
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Cat.#:ALAD-2413ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish ALAD
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Cat.#:ALAD-54HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human ALAD cell lysate
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Involved Pathway

ALAD involved in several pathways and played different roles in them. We selected most pathways ALAD participated on our site, such as Porphyrin and chlorophyll metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with ALAD were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Porphyrin and chlorophyll metabolism
UGT1A3; HMBSB; HEPH; HCCSA.1; UGT1A4; FECH; HCCSB; GUSB; ALAS2; HMOX1
Metabolic pathways
SYNJ1; TWISTNB; RDH11; ATP6V0A1; TYR; MCEE; ENPP7; NT5E; DAO.2; PLA2G4D

Protein Function

ALAD has several biochemical functions, for example, catalytic activity, identical protein binding, lead ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ALAD itself. We selected most functions ALAD had, and list some proteins which have the same functions with ALAD. You can find most of the proteins on our site.
Function
Related Protein
Function catalytic activity
Related Protein PPM1BB; PNP5A; PGGT1B; RSAD1; GPT2L; SYN3; FHIT; PHYKPL; DIP2A; PHKB
Function identical protein binding
Related Protein FGFR1; DHX8; PVRL2; SNX33; PSME3; CIDEB; ALCAMA; MYD88; YWHAZ; STIM1
Function lead ion binding
Related Protein ALAD
Function porphobilinogen synthase activity
Related Protein ALAD
Function zinc ion binding
Related Protein USP3; QPCTLA; LHX1A; BRF1A; ZRANB3; USP44; MMP25; CBLC; UQCRC2B; TAB2

Interacting Protein

ALAD has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ALAD here. Most of them are supplied by our site. Hope this information will be useful for your research of ALAD.
Alad; 15-deoxy-delta(12,14

ALAD Related Articles

Bardag-Gorce, F; French, SW; et al. Delta-aminolevulinic dehydratase is a proteasome interacting protein. EXPERIMENTAL AND MOLECULAR PATHOLOGY 91:485-489(2011).
Varadharajan, S; Sagar, BKC; et al. Localization of ferrochelatase in Plasmodium falciparum. BIOCHEMICAL JOURNAL 384:429-436(2004).