ACTG1
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Official Full Name
actin, gamma 1
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Overview
Actins are highly conserved proteins that are involved in various types of cell motility, and maintenance of the cytoskeleton. In vertebrates, three main groups of actin isoforms, alpha, beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins co-exist in most cell types as components of the cytoskeleton, and as mediators of internal cell motility. Actin, gamma 1, encoded by this gene, is a cytoplasmic actin found in non-muscle cells. Mutations in this gene are associated with DFNA20/26, a subtype of autosomal dominant non-syndromic sensorineural progressive hearing loss. Alternative splicing results in multiple transcript variants. -
Synonyms
ACTG1; actin, gamma 1; ACTG, deafness, autosomal dominant 20; deafness, autosomal dominant 26 , DFNA20, DFNA26; actin, cytoplasmic 2; cytoplasmic 2; N-terminally processed; ACT; ACTB; ACTG; ACTG_HUMAN; Actin; Actin, gamma 1 propeptide; Cytoskeletal gamma actin; Deafness, autosomal dominant 20; Deafness, autosomal dominant 26; DFNA20; DFNA26; Gamma-actin; cytoskeletal gamma-actin;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- E. coli
- E.coli
- E.Coli or Yeast
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- C
- His
- Myc
- DDK
- Flag
- GST
- His (Fc)
- Avi
- His|GST
- MYC
- N/A
- N
- T7
- Involved Pathway
- Protein Function
- Interacting Protein
- ACTG1 Related Articles
ACTG1 involved in several pathways and played different roles in them. We selected most pathways ACTG1 participated on our site, such as Rap signaling pathway, Phagosome, Hippo signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with ACTG1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Rap signaling pathway | PIK3R2;HGF;FGF2;PIK3R3;PDGFRB;FGF20;GNAI2;Adcy4;PFN3 |
| Phagosome | BF1;HLA-G;Itgam&Itgb2;HLA-DMA;FCGR1A;TLR4;TUBA8L4;RAB5AB;ATP6V0A1B |
| Hippo signaling pathway | PPP2R2D;LEF1;CCND2;FZD2;CRB2;CCND1;FZD1;WNT5A;BMP7 |
| Focal adhesion | TNXB;LAMB1A;IGF1RA;PPP1CAB;ITGA10;RAC2;MAPK1;COL4A1;MAP2K1 |
| Adherens junction | PVRL1;WASF1;ACTN4;WASF3B;SSX2IP;BAIAP2A;SMAD3;ACTN3A;MET |
| Tight junction | PRKCB;CLDN17;MYH11;CLDN15LA;PRKCQ;MAGI2;MYH1;YBX3;RRAS |
| Platelet activation | MYL12B;PIK3R1;COL27A1;GUCY1A3;GNAI1;PPP1CB;PTGS1;PIK3R5;PLA2G4C |
| Leukocyte transendothelial migration | ITGAM;VCAM1;CLDN18;CYBB;THY1;PRKCG;CLDN22;PRKCA;NOX3 |
| Regulation of actin cytoskeleton | ITGA1;TMSB;PIK3R3;SCIN;PIK3R5;IQGAP2;INSB;ABI2;RAF1B |
| Thyroid hormone signaling pathway | PLCD4;ATP1A1;ATP1A3;PIK3CD;RXRB;MAPK1;NOTCH2;RXRA;STAT1 |
| Oxytocin signaling pathway | PPP1CB;CACNG8;PRKAA2;PIK3R3;KRAS;ELK1;ROCK1;CAMK1;CAMK1G |
| Bacterial invasion of epithelial cells | CAV1;PIK3CD;MET;WASL;CAV3;CTNNA1;MAD2L2;SHC3;ARPC4 |
| Vibrio cholerae infection | ATP6V0A4;ERO1L;PLCG1;ATP6V1C1;MUC2;ATP6V1C2;PRKACA;ATP6V0C;ATP6V1D |
| Pathogenic Escherichia coli infection | CTTN;ABL1;YWHAZ;TUBB1;WASL;ITGB1;ROCK2;EZR;CDC42 |
| Shigellosis | ELMO3;DIAPH1;ITGB1;CD44;U2AF1;ELMO1;CDC42;RIPK2;U2AF1L4 |
| Salmonella infection | CCL4L1;KLC1A;WASB;WASL;CXCL3;DYNC1I1;IL-8;CXCL1;PKN2 |
| Influenza A | OAS1B;STAT2;IFNA3;ACTG1;PABPN1L;ICAM1;CYCS;TMPRSS13;HNRNPUL1 |
| Proteoglycans in cancer | PTCH1;WNT7B;CDC42;HIF1A;FZD7;HPSE2;PIK3CG;LUM;ERBB4 |
| Hypertrophic cardiomyopathy (HCM) | ITGA9;TPM3;ITGA5;SGCB;ITGB1;CACNB3;ITGA8;DAG1;TPM4 |
| Arrhythmogenic right ventricular cardiomyopathy (ARVC) | ACTN4;CACNA2D3;ITGA7;DSP;DMD;DAG1;ITGA5;JUP;ACTN2 |
| Dilated cardiomyopathy | SGCA;CACNG8;ITGA3;ITGA10;TGFB3;PLN;ITGA7;DMD;Itga10&Itgb1 |
| Viral myocarditis | HLA-DQA2;HLA-DRB1;ABL1;ITGAL;HLA-F;CASP9;H2-AB1;SGCG;RAC1 |
ACTG1 has several biochemical functions, for example, ATP binding, identical protein binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ACTG1 itself. We selected most functions ACTG1 had, and list some proteins which have the same functions with ACTG1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | DGKD;HARS2;TYK2;RARS;WRNIP1;WNK1;CLPB;WEE2;UBE2IB |
| identical protein binding | BNIP2;C1QL4;TPCN1;USP15;PHYKPL;DDX58;CCDC91;S100A4;PLDN |
| protein binding | PRSS3;PEX26;TNFRSF13B;CACNB4;GABRG2;IMPA1;BMF;GTPBP3;KLC2 |
| structural constituent of cytoskeleton | TUBGCP5;MSN;KRT5;ARPC2;TUBGCP3;TUBB4A;ATXN1;SPTB;SPTBN1 |
| ubiquitin protein ligase binding | CDKN1A;JAK1;EGR2;ABI2;RB1;KDM4A;NAE1;BLZF1;SMC6 |
ACTG1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ACTG1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ACTG1.
ACTB; DSTN; CFL1
- Q&As
- Reviews
Q&As (20)
Ask a questionACTG1 plays a crucial role in cytoskeletal dynamics, cell division, cell migration, and maintaining cell shape.
ACTG1 mutation leads to hearing loss in humans.
GO function and pathway enrichment analysis suggest that inflammatory response plays a crucial role in IDD based on differentially expressed genes (DEGs) from microarray datasets.
Yes, bioinformatics analysis suggests that ACTG1 might be a hub gene in IDD.
It is proposed that ACTG1 regulates the fitness of uterine cancer cells by modulating cell-intrinsic properties and the tumor microenvironment.
ACTG1 regulates the development of IDD through the NF-κB-p65 and Akt pathways.
ACTG1 gains in uterine cancers are associated with transcriptional patterns reflecting activation of oncogenic signals, repression of response to innate immunity, or immunotherapy.
In the protein-protein interaction (PPI) network, ACTG1 is connected to proteins involved in inflammation-related pathways.
The knockdown of ACTG1 suppresses the proliferation and migration of tumor cells.
Yes, the low expression of ACTG1 is also found in degenerated NP tissues in rats.
Yes, ACTG1 mutations can be inherited in an autosomal dominant pattern, which means that one copy of the mutated gene is sufficient to cause the condition.
Depletion of ACTG1 in human NP cells increases MMP3 expression, decreases collagen II levels, and leads to excessive apoptosis, exacerbating IDD.
ACTG1's functions relative to other actomyosin genes support the notion that it is a potential biomarker and a target gene in precision therapies for uterine cancer.
Yes, based on the findings, ACTG1 may serve as a novel marker and therapeutic target for IDD in the future.
Uterine cancers, including mixed endometrial carcinomas, serous carcinomas, endometroid carcinomas, and carcinosarcomas, have the highest frequencies of ACTG1 gene amplification or overexpression.
Patients with ACTG1 gains in uterine cancers have a poor prognosis.
The ACTG1 gene encodes the protein actin gamma-1, which is involved in cell structure and movement.
The expression of ACTG1 is low in severely degenerated nucleus pulposus (NP) tissues compared to mildly degenerated samples. The ACTG1 level is negatively correlated with human disc degeneration grades.
The deletion of ACTG1 using CRISPR-CAS9 gene editing has robust and consistent effects on uterine cancer cells, indicating its functional importance in these cells compared to 20 other lineages.
Yes, mutations in ACTG1 have been linked to conditions such as Baraitser-Winter syndrome and nonsyndromic hearing loss.
Customer Reviews (5)
Write a reviewThe functional assays using the protein product consistently yield strong and reproducible signals, indicating its high efficacy.
The protein product was carefully packaged, with appropriate cold-chain shipping to maintain its stability and integrity.
It shows remarkable lot-to-lot consistency, ensuring reliable and reproducible experimental outcomes.
The protein product exhibits exceptional stability, maintaining its structural integrity even under challenging experimental conditions.
The company's representatives were knowledgeable and provided valuable guidance on experimental protocols and optimization.
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