Recombinant Human ACTG1 protein, T7-tagged
Cat.No. : | ACTG1-162H |
Product Overview : | Recombinant human ACTG1 (357 aa) fused with T7 Tag at N-terminal was expressed in E. coli. |
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Source : | E. coli |
Species : | Human |
Tag : | T7 |
Form : | 1.0 mg/ml, sterile-filtered, in 20 mM pH 8.0 Tris-HCl Buffer, with proprietary formulation of NaCl, KCl, EDTA, Sucrose and DTT. |
AA Sequence : | MASMTGGQQMGRGEFGSEEEIAALV IDNGSGMCKAGFAGDDAPRAVFPSI VGRPRHQGVMVGMGQKDSYVGDEAQ SKRGILTLKYPIEHGIVTNWDDMEK IWHHTFYNELRVAPEEHPVLLTEAP LNKANREKMTQIMFETFNTPAMYVA IQAVLSLYASGRTTGIVMDSGDGVT HTVPIYEGYALPHAILRLDLAGRDL TDYLMKILTERGYSFTTTAEREIVR DIKEKLCYVALDFEQEMATAASSSS LEKSYELPDGQVITIGNERFRCPEA LFQPSFLGMESCGIHETTFNSIMKC DVDIRKDLYANTVLSGGTTMYPGIA DRMQKEITALAPSTMKIKIIAPPER KYSVWIGGSILASLSTFQQMWISKQ EYDESGPSIVHRKCF |
Purity : | >90% by SDS-PAGE |
Storage : | Keep at -80 centigrade for long term storage. Product is stable at 4 centigrade for at least 7 days. |
Gene Name : | ACTG1 actin, gamma 1 [ Homo sapiens ] |
Official Symbol : | ACTG1 |
Synonyms : | ACTG1; actin, gamma 1; ACTG, deafness, autosomal dominant 20; deafness, autosomal dominant 26 , DFNA20, DFNA26; actin, cytoplasmic 2; cytoskeletal gamma-actin; ACT; ACTG; DFNA20; DFNA26; |
Gene ID : | 71 |
mRNA Refseq : | NM_001199954 |
Protein Refseq : | NP_001186883 |
MIM : | 102560 |
UniProt ID : | P63261 |
Chromosome Location : | 17q25 |
Pathway : | Adherens junction, organism-specific biosystem; Adherens junction, conserved biosystem; Arrhythmogenic right ventricular cardiomyopathy (ARVC), organism-specific biosystem; Arrhythmogenic right ventricular cardiomyopathy (ARVC), conserved biosystem; Bacterial invasion of epithelial cells, organism-specific biosystem; Bacterial invasion of epithelial cells, conserved biosystem; Dilated cardiomyopathy, organism-specific biosystem; |
Function : | ATP binding; identical protein binding; nucleotide binding; protein binding; protein kinase binding; structural constituent of cytoskeleton; |
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ACTG1-2806H | Recombinant Human ACTG1 protein(41-290 aa), C-His-tagged | +Inquiry |
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ACTG1-269H | Recombinant Human ACTG1 Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
ACTG1-9064HCL | Recombinant Human ACTG1 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (20)
Ask a questionACTG1 plays a crucial role in cytoskeletal dynamics, cell division, cell migration, and maintaining cell shape.
ACTG1 mutation leads to hearing loss in humans.
GO function and pathway enrichment analysis suggest that inflammatory response plays a crucial role in IDD based on differentially expressed genes (DEGs) from microarray datasets.
Yes, bioinformatics analysis suggests that ACTG1 might be a hub gene in IDD.
It is proposed that ACTG1 regulates the fitness of uterine cancer cells by modulating cell-intrinsic properties and the tumor microenvironment.
ACTG1 regulates the development of IDD through the NF-κB-p65 and Akt pathways.
ACTG1 gains in uterine cancers are associated with transcriptional patterns reflecting activation of oncogenic signals, repression of response to innate immunity, or immunotherapy.
In the protein-protein interaction (PPI) network, ACTG1 is connected to proteins involved in inflammation-related pathways.
The knockdown of ACTG1 suppresses the proliferation and migration of tumor cells.
Yes, the low expression of ACTG1 is also found in degenerated NP tissues in rats.
Yes, ACTG1 mutations can be inherited in an autosomal dominant pattern, which means that one copy of the mutated gene is sufficient to cause the condition.
Depletion of ACTG1 in human NP cells increases MMP3 expression, decreases collagen II levels, and leads to excessive apoptosis, exacerbating IDD.
ACTG1's functions relative to other actomyosin genes support the notion that it is a potential biomarker and a target gene in precision therapies for uterine cancer.
Yes, based on the findings, ACTG1 may serve as a novel marker and therapeutic target for IDD in the future.
Uterine cancers, including mixed endometrial carcinomas, serous carcinomas, endometroid carcinomas, and carcinosarcomas, have the highest frequencies of ACTG1 gene amplification or overexpression.
Patients with ACTG1 gains in uterine cancers have a poor prognosis.
The ACTG1 gene encodes the protein actin gamma-1, which is involved in cell structure and movement.
The expression of ACTG1 is low in severely degenerated nucleus pulposus (NP) tissues compared to mildly degenerated samples. The ACTG1 level is negatively correlated with human disc degeneration grades.
The deletion of ACTG1 using CRISPR-CAS9 gene editing has robust and consistent effects on uterine cancer cells, indicating its functional importance in these cells compared to 20 other lineages.
Yes, mutations in ACTG1 have been linked to conditions such as Baraitser-Winter syndrome and nonsyndromic hearing loss.
Customer Reviews (5)
Write a reviewThe functional assays using the protein product consistently yield strong and reproducible signals, indicating its high efficacy.
The protein product was carefully packaged, with appropriate cold-chain shipping to maintain its stability and integrity.
It shows remarkable lot-to-lot consistency, ensuring reliable and reproducible experimental outcomes.
The protein product exhibits exceptional stability, maintaining its structural integrity even under challenging experimental conditions.
The company's representatives were knowledgeable and provided valuable guidance on experimental protocols and optimization.
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