| Description : |
Actins are highly conserved proteins that are involved in various types of cell motility and in maintenance of the cytoskeleton. Three main groups of actin isoforms have been identified in vertebrate animals: alpha, beta, and gamma. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins co-exist in most cell types as components of the cytoskeleton and as mediators of internal cell motility. Actin gamma 1, encoded by this gene, is a cytoplasmic actin found in all cell types. Mutations in this gene are associated with DFNA20/26, a subtype of autosomal dominant non-syndromic sensorineural progressive hearing loss and also with Baraitser-Winter syndrome. Alternative splicing results in multiple transcript variants. |
| Source : |
Mammalian cells |
| Species : |
Human |
| Tag : |
Flag |
| Form : |
25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
| Molecular Mass : |
41.6 kDa |
| AA Sequence : |
MEEEIAALVIDNGSGMCKAGFAGDD APRAVFPSIVGRPRHQGVMVGMGQK DSYVGDEAQSKRGILTLKYP IEHGIVTNWDDMEKIWHHTFYNELR VAPEEHPVLLTEAPLNPKANREKMT QIMFETFNTPAMYVAIQAVL SLYASGRTTGIVMDSGDGVTHTVPI YEGYALPHAILRLDLAGRDLTDYLM KILTERGYSFTTTAEREIVR DIKEKLCYVALDFEQEMATAASSSS LEKSYELPDGQVITIGNERFRCPEA LFQPSFLGMESCGIHETTFN SIMKCDVDIRKDLYANTVLSGGTTM YPGIADRMQKEITALAPSTMKIKII APPERKYSVWIGGSILASLS
TFQQMWISKQEYDESGPSIVHRKCF TRTRPLEQKLISEEDLAANDILDYK DDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining. |
| Stability : |
Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
| Storage : |
Store at -80 centigrade. |
| Concentration : |
>50 ug/mL as determined by microplate BCA method. |
| Preparation : |
Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
| Protein Pathways : |
Adherens junction, Arrhythmogenic right ventricular cardiomyopathy (ARVC), Dilated cardiomyopathy, Focal adhesion, Hypertrophic cardiomyopathy (HCM), Leukocyte transendothelial migration, Pathogenic Escherichia coli infection, Regulation of actin cytoskeleton, Tight junction, Vibrio cholerae infection, Viral myocarditis |
