cul4a
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  • Official Full Name
  • cullin 4A
  • Background
  • CUL4A is the ubiquitin ligase component of a multimeric complex involved in the degradation of DNA damage-response proteins.
  • Synonyms
  • CUL4A; cullin 4A; cullin-4A; CUL-4A; OTTHUMP00000018753; OTTHUMP00000018754
Cat.#:CUL4A-2134HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CUL4A Protein, GST-tagged
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Cat.#:CUL4A-2180HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human CUL4A Protein, MYC/DDK-tagged
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Cat.#:CUL4A-4078MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse CUL4A Protein
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Cat.#:CUL4A-11259ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish CUL4A
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Cat.#:CUL4A-7182HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human CUL4A 293 Cell Lysate
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Involved Pathway

CUL4A involved in several pathways and played different roles in them. We selected most pathways CUL4A participated on our site, such as Nucleotide excision repair, Ubiquitin mediated proteolysis, which may be useful for your reference. Also, other proteins which involved in the same pathway with CUL4A were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Nucleotide excision repair
LIG1; COPS3; RPA2; USP45; RAD23AA; POLE4; GTF2H2C_2; RBX1; POLD2; ERCC2
Ubiquitin mediated proteolysis
UBE2D1; UBE2KB; CUL3A; KEAP1B; SOCS1A; UBE2U; RCHY1; BIRC2; ANAPC11; CUL5

Protein Function

CUL4A has several biochemical functions, for example, protein binding, contributes_to ubiquitin protein ligase activity, ubiquitin protein ligase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CUL4A itself. We selected most functions CUL4A had, and list some proteins which have the same functions with CUL4A. You can find most of the proteins on our site.
Function
Related Protein
Function protein binding
Related Protein SUPV3L1; PRMT6; VTI1B; ITGAM; RNF19B; PLEKHG2; BAK1; VIM; TSN; IL1R2
Function contributes_to ubiquitin protein ligase activity
Related Protein CUL1B; FBXL17; SKP2; FBXL4; MED12; CUL1A; C10orf46; CUL5; FBXL22; FBXL2
Function ubiquitin protein ligase binding
Related Protein BLZF1; CKB; PPARGC1A; PRDX6; RPA2; AXIN1; BAG6; EIF4E2; HIF1A; SMAD5

Interacting Protein

CUL4A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CUL4A here. Most of them are supplied by our site. Hope this information will be useful for your research of CUL4A.
DDB1; CAND1; DDB2; Dtl; Ddb1; COPS5; RBBP5