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DCT

Official Full Name

dopachrome tautomerase (dopachrome delta-isomerase, tyrosine-related protein 2)
Overview

Dopachrome tautomerase (dopachrome delta-isomerase, tyrosine-related protein 2), also known as DCT, is a human gene . Its expression is regulated by the microphthalmia-associated transcription factor (MITF).
Synonyms

DCT; dopachrome tautomerase (dopachrome delta-isomerase, tyrosine-related protein 2); TYRP2; L-dopachrome tautomerase; L dopachrome tautomerase; Dopachrome delta isomerase; Dopachrome tautomerase; Dopachrome tautomerase dopachrome delta isomerase, tyrosine related protein 2; DT; EC 5.3.3.12; L dopachrome Delta isomerase; L-dopachrome Delta-isomerase; TRP 2; TRP-2; TRP2; Tyrosinase related protein 2; Tyrosinase-related protein 2; TYRP2_HUMAN; OTTHUMP00000018553; dopachrome delta-isomerase;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Chicken
Gallus gallus (Chicken)
Homo sapiens (Human)
Human
Mouse
Mus musculus (Mouse)
Zebrafish

Source

E.coli
E.coli expression system
HEK293
HEK293T
In Vitro Cell Free System
Mammalian Cell
Mammalian cells
Wheat Germ

Tag

Flag
GST
His
His (Fc)
Avi
His|SUMO
His|SUMO|Myc
His|T7
SUMO
Myc
DDK
N/A
N

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	DCT-11864H	Recombinant Human DCT protein, His-tagged	E.coli	His	1-350 aa	$319 / 25ug
Human	DCT-1456H	Recombinant Human DCT protein, His & T7-tagged	E.coli	His/T7	Val28~Gly263 (Accession # P40126)	Inquiry
Human	DCT-2406H	Recombinant Human DCT Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	DCT-1182H	Recombinant Human DCT Protein, His-SUMO/MYC-tagged	E.coli	His/SUMO/Myc		Inquiry
Human	DCT-7045HCL	Recombinant Human DCT 293 Cell Lysate	HEK293	N/A		Inquiry
Human	DCT-401HFL	Recombinant Full Length Human DCT Protein, C-Flag-tagged	Mammalian cells	Flag		Inquiry
Human	DCT-2880H	Recombinant Human DCT protein, His-tagged	E.coli	His	1-350 aa	$319 / 25ug
Human	DCT-728H	Recombinant Human DCT Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Human	DCT-2934HF	Recombinant Full Length Human DCT Protein, GST-tagged	In Vitro Cell Free System	GST	519 amino acids	Inquiry
Human	DCT-1932H	Recombinant Human DCT Protein (Val28-Gly263), N-His tagged	E.coli	N-His	Val28-Gly263	Inquiry
Human	DCT-728H-B	Recombinant Human DCT Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	DCT-4363M	Recombinant Mouse DCT Protein	Mammalian Cell	His		Inquiry
Mouse	DCT-1183M	Recombinant Mouse DCT Protein, His-SUMO-tagged	E.coli	His/SUMO		Inquiry
Mouse	DCT-2240M	Recombinant Mouse DCT Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	Dct-2479M	Recombinant Mouse Dct Protein, Myc/DDK-tagged	HEK293T	Myc/DDK		Inquiry
Mouse	Dct-2806M	Recombinant Mouse Dct protein, His-SUMO & Myc-tagged	E.coli	His-SUMO & Myc	24-472aa	Inquiry
Mouse	DCT-2240M-B	Recombinant Mouse DCT Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Gallus gallus (Chicken)	RFL18547GF	Recombinant Full Length Chicken L-Dopachrome Tautomerase(Dct) Protein, His-Tagged	E.coli expression system	His	Full Length of Mature Protein (26-521)	Inquiry
Homo sapiens (Human)	RFL32608HF	Recombinant Full Length Human L-Dopachrome Tautomerase(Dct) Protein, His-Tagged	E.coli expression system	His	Full Length of Mature Protein (24-519)	Inquiry
Mus musculus (Mouse)	RFL16078MF	Recombinant Full Length Mouse L-Dopachrome Tautomerase(Dct) Protein, His-Tagged	E.coli expression system	His	Full Length of Mature Protein (24-517)	Inquiry
Zebrafish	DCT-9099Z	Recombinant Zebrafish DCT	Mammalian Cell	His		Inquiry
Chicken	DCT-6495C	Recombinant Chicken DCT	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
DCT Related Articles

DCT involved in several pathways and played different roles in them. We selected most pathways DCT participated on our site, such as Melanin biosynthesis, Melanogenesis, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with DCT were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Melanin biosynthesis
Melanogenesis	CALM2B;GNAO1;FZD3;CALM3A;CALM2A;KITB;PLCB4;CALML5;GNA11A
Metabolic pathways	CYP1A;ALP3;ALPI.2;ACSL1;SUCLG2;SDHC;SPTLC2;CAD;PTDSS2
Metabolism	ACOT13;AK8;ADH8A;CPTP;NAT2;ACOT8;SCO1;APOEB;NUDT10
Metabolism of amino acids and derivatives	DBH;SLC6A8;SLC25A15A;IVD;HIBADH;SLC25A21;CKM;SLC25A2;AFMID
Neural Crest Differentiation	CDH6;TBX6;PHOX2B;PRTG;HOXA1;OLIG3;CDH7;SOX5;DMBX1
Tyrosine metabolism	COMTB;ALDH1A3;TPO;GOT1;AOC2;AOX3;AOC3;GOT2B;MAOA

DCT has several biochemical functions, for example, copper ion binding, dopachrome isomerase activity, oxidoreductase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DCT itself. We selected most functions DCT had, and list some proteins which have the same functions with DCT. You can find most of the proteins on our site.

Function	Related Protein
copper ion binding	S100V2;PRND;ADNP;LOXL4;PARK7;HAMP;ABHD1;CUTC;MOXD2
dopachrome isomerase activity	DCT;DDT;MIF
oxidoreductase activity	AOX4;G6PDX;CYP19A1A;ALDH9A1A.1;CYP2X9;RDH10B;ADOA;CYP2C8;CYP3A5

DCT has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DCT here. Most of them are supplied by our site. Hope this information will be useful for your research of DCT.

Ueno, M; Aoto, T; et al. Coupling of the radiosensitivity of melanocyte stem cells to their dormancy during the hair cycle. PIGMENT CELL & MELANOMA RESEARCH 27:-(2014).

Filimon, A; Zurac, SA; et al. Value of dopachrome tautomerase detection in the assessment of melanocytic tumors. MELANOMA RESEARCH 24:219-236(2014).