Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at BIO-Europe Spring|March 18–20, 2024|Booth #34

GABRB3

  • Official Full Name

    gamma-aminobutyric acid (GABA) A receptor, beta 3

  • Overview

    Gamma-aminobutyric acid type A (GABAA) receptors are members of the neurotransmitter ligand-gated ion channels that mediate neuronal inhibition on binding GABA. The effects of GABA on GABAA receptors are modulated by a range of therapeutically important drugs, including barbiturates, anaesthetics and benzodiazepines.
  • Synonyms

    Gamma-aminobutyric acid type A receptors; GABAA receptors; GABRB3; gamma-aminobutyric acid (GABA) A receptor, beta 3; gamma-aminobutyric acid receptor subunit beta-3;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Rat
  • Rattus norvegicus (Rat)
  • Rhesus Macaque
  • E.coli
  • E.coli expression system
  • HEK293
  • Mammalian cell
  • Mammalian Cell
  • Wheat Germ
  • C
  • StrepII
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
  • N
  • Tag
  • Free
  • twin
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human GABRB3-28089TH Recombinant Human GABRB3 Wheat Germ N/A 110 amino acids
Human GABRB3-6060HCL Recombinant Human GABRB3 293 Cell Lysate HEK293 N/A
Human GABRB3-3749H Recombinant Human GABRB3 protein, GST-tagged E.coli GST 371-426 aa
Human GABRB3-4647H Recombinant Human GABRB3 Protein, GST-tagged Wheat Germ GST
Human GABRB3-05H Recombinant Human GABRB3 Protein (M1-F332, SQPARAA, A447-N473 end), C-StrepII-tagged Mammalian cell C-StrepII M1-F332, SQPARAA, A447-N473 end
Human GABRB3-1550H Recombinant Human GABRB3 Protein, His&GST-tagged E.coli N-His&GST Gln26-Tyr245
Human GABRB3-0625H Recombinant Human GABRB3 Protein (M1-F332, A447-N473 end), twin-StrepII tagged Mammalian cell twin-StrepII M1-F332, A447-N473 end
Rat GABRB3-2450R Recombinant Rat GABRB3 Protein Mammalian Cell His
Rat GABRB3-2106R Recombinant Rat GABRB3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat GABRB3-2106R-B Recombinant Rat GABRB3 Protein Pre-coupled Magnetic Beads HEK293
Rattus norvegicus (Rat) RFL28591RF Recombinant Full Length Rat Gamma-Aminobutyric Acid Receptor Subunit Beta-3(Gabrb3) Protein, Tag-Free E.coli expression system Tag-Free Full Length of Mature Protein (26-473)
Rhesus Macaque GABRB3-1795R Recombinant Rhesus monkey GABRB3 Protein, His-tagged Mammalian Cell His
Rhesus Macaque GABRB3-1616R-B Recombinant Rhesus Macaque GABRB3 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque GABRB3-1616R Recombinant Rhesus Macaque GABRB3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Chicken GABRB3-6898C Recombinant Chicken GABRB3 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • GABRB3 Related Articles
  • GABRB3 Related Research Area

GABRB3 involved in several pathways and played different roles in them. We selected most pathways GABRB3 participated on our site, such as Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, Serotonergic synapse, which may be useful for your reference. Also, other proteins which involved in the same pathway with GABRB3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Neuroactive ligand-receptor interactionGNRHR2;LPAR6;DRD1A;P2RX3;TSPO;PTGER1;FPR2;TAAR7F;P2RY10
Retrograde endocannabinoid signalingPRKCG;GNAI1;GNG11;GNG2;GRIA1;MAPK11;GABRD;GABRA3;GNB3
Serotonergic synapseCYP2C39;ALOX15;GNGT2;GNB3;MAPK3;CYP4X1;HTR3C;PLA2G4D;GABRB3
GABAergic synapseGNG8;PLCL1;PRKACB;GLUL;GABRR2;PRKACG;GABARAPL1;GNAI2;GNG4
Nicotine addictionGRIA4;GABRP;GRIN2C;GABRA3;GABRG1;GABRD;GRIA2;SLC17A7;GABRG3

GABRB3 has several biochemical functions, for example, GABA-A receptor activity, GABA-gated chloride ion channel activity, contributes_to chloride channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GABRB3 itself. We selected most functions GABRB3 had, and list some proteins which have the same functions with GABRB3. You can find most of the proteins on our site.

Function Related Protein
GABA-A receptor activityGABRA1;GABRR2;GABRR3;GABRR2A;GABRG2;GABRE;GABRD;GABRB2;GABRB3
GABA-gated chloride ion channel activity
contributes_to chloride channel activityGABRB2;BEST2;BEST4;GABRB1;GABRR3A;GABRQ;GABRR2A;BEST3;GABRB3
contributes_to extracellular ligand-gated ion channel activityGABRQ;GABRR3A;GABRR2;GABRB1;GABRB2;GABRZ;GABRR2A;GABRB3

GABRB3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GABRB3 here. Most of them are supplied by our site. Hope this information will be useful for your research of GABRB3.

Arfgef2

Zhao, CJ; Eisinger, BE; et al. Addiction and reward-related genes show altered expression in the postpartum nucleus accumbens. FRONTIERS IN BEHAVIORAL NEUROSCIENCE 8:-(2014).
Srivastava, S; Cohen, J; et al. A Novel Variant in GABRB2 Associated with Intellectual Disability and Epilepsy. AMERICAN JOURNAL OF MEDICAL GENETICS PART A 164A:2914-2921(2014).
  • Q&As
  • Reviews

Q&As (7)

Ask a question
How is GABRB3 linked to autism and epilepsy? 09/05/2022

Mutations and altered GABRB3 expression increase risk for autism and certain epilepsies.

What is GABRB3's primary function in the central nervous system? 04/24/2022

GABRB3 is essential for inhibitory neurotransmission as part of the GABA-A receptor.

How does GABRB3 expression vary with development? 03/14/2022

GABRB3 shows higher expression in early development, varying across stages.

What effects does GABRB3 gene knockout have in animal models? 01/03/2022

GABRB3 knockout results in behavioral abnormalities and synaptic changes.

What post-translational modifications occur on GABRB3? 11/14/2019

GABRB3 undergoes phosphorylation, impacting receptor activity.

What are GABRB3's potential therapeutic applications? 08/27/2019

Targeting GABRB3 may benefit disorders related to GABAergic dysfunction, like epilepsy and anxiety.

Can you list GABRB3's known interacting partners? 02/27/2019

GABRB3 interacts with other GABA-A receptor subunits for proper function.

Customer Reviews (3)

Write a review
Reviews
05/04/2019

    Would definitely recommend.

    08/27/2018

      Easy to work with.

      02/22/2018

        Fantastic product, very happy.

        Ask a Question for All GABRB3 Products

        Required fields are marked with *

        My Review for All GABRB3 Products

        Required fields are marked with *

        logo

        FOLLOW US

        Terms and Conditions        Privacy Policy

        Copyright © 2024 Creative BioMart. All Rights Reserved.

        Contact Us

        • /

        Stay Updated on the Latest Bioscience Trends