grb14
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  • Official Full Name
  • growth factor receptor-bound protein 14
  • Background
  • The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. This protein likely has an inhibitory effect on receptor tyrosine kinase signaling and, in particular, on insulin receptor signaling. This gene may play a role in signaling pathways that regulate growth and metabolism. Transcript variants have been reported for this gene, but their full-length natures have not been determined to date.
  • Synonyms
  • GRB14; growth factor receptor-bound protein 14; GRB14 adapter protein; Growth factor receptorbound protein 14
Cat.#:GRB14-538HTag:MYC/DDK
Source (Host):HEK293TSpecies:Human
Product nameRecombinant Human GRB14 Protein, MYC/DDK-tagged
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Cat.#:GRB14-1432HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GRB14 Protein, His-tagged
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Cat.#:GRB14-5037HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human GRB14 Protein, GST-tagged
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Cat.#:GRB14-13519HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GRB14, His-tagged
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Cat.#:Grb14-1736MTag:His/T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Grb14 protein, His & T7-tagged
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Cat.#:Grb14-1737RTag:His/T7
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Grb14 protein, His & T7-tagged
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Cat.#:GRB14-2685RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat GRB14 Protein
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Cat.#:GRB14-5756HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human GRB14 293 Cell Lysate
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Involved Pathway

GRB14 involved in several pathways and played different roles in them. We selected most pathways GRB14 participated on our site, such as Angiopoietin receptor Tie2-mediated signaling, Cell surface interactions at the vascular wall, EGFR1 Signaling Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with GRB14 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Angiopoietin receptor Tie2-mediated signaling
DOK2; ELF2; CDKN1A; ELF1; BMX; GRB14; CRK; GRB7; AGTR1
Cell surface interactions at the vascular wall
GRB7; NADL1.1; CEACAM8; SLC3A2B; SLC16A1; SLC7A8A; SLC16A8; SLC3A2A; MERTK; JAM2B
EGFR1 Signaling Pathway
PTPN12; PTK6; REPS1; SPRY2; KLF11; REPS2; JUND; EPS8; GRB14; ZPR1
Hemostasis
CFHL2; SIRPA; SERPINB8; PROCA; RACGAP1; CXADR; CLU; CLEC1B; TAE1; FCER1GL
Insulin Pathway
EXOC3; EXOC6; GRB14; EXOC5; DOK1; GRB10; EXOC1
Insulin Signaling
MAP3K10; SGK2; MAP3K2; RRAD; STXBP3; ARHGAP33; GRB14; MAPK6; STXBP1A; GRB10
Tie2 Signaling
ANGPT2A; GRB14; DOK2

Protein Function

GRB14 has several biochemical functions, for example, SH3/SH2 adaptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GRB14 itself. We selected most functions GRB14 had, and list some proteins which have the same functions with GRB14. You can find most of the proteins on our site.
Function
Related Protein
Function SH3/SH2 adaptor activity
Related Protein SH2D1A; GRAP; FCRL2; SRC; SLA2; PTPN11; STAP1; STAM; SLA; SH2D3A

Interacting Protein

GRB14 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GRB14 here. Most of them are supplied by our site. Hope this information will be useful for your research of GRB14.
IGF1R; STK26; rabbit_gsk3_beta; MET; CSNK2A1; INSR; INSR; NFKB1; GSK3B; FRS3; HCK; CDC5L

GRB14 Related Articles

Nouaille, S; Blanquart, C; et al. Interaction between the insulin receptor and Grb14: A dynamic study in living cells using BRET. BIOCHEMICAL PHARMACOLOGY 72:1355-1366(2006).
Nouaille, S; Blanquart, C; et al. Interaction with Grb14 results in site-specific regulation of tyrosine phosphorylation of the insulin receptor. EMBO REPORTS 7:512-518(2006).