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ARID1A

  • Official Full Name

    AT rich interactive domain 1A (SWI-like)

  • Overview

    This gene encodes a member of the SWI/SNF family, whose members have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. It possesses at least two conserved domains that could be important for its function. First, it has a DNA-binding domain that can specifically bind an AT-rich DNA sequence known to be recognized by a SNF/SWI complex at the beta-globin locus. Second, the C-terminus of the protein can stimulate glucocorticoid receptor-dependent transcriptional activation. It is thought that the protein encoded by this gene confers specificity to the SNF/SWI complex and may recruit the complex to its targets through either protein-DNA or protein-protein interactions. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
  • Synonyms

    ARID1A; AT rich interactive domain 1A (SWI-like); ELD; B120; OSA1; P270; hELD; BM029; MRD14; hOSA1; BAF250; C1orf4; BAF250a; SMARCF1; AT-rich interactive domain-containing protein 1A; osa homolog 1; SWI-like protein; brain protein 120; OSA1 nuclear protein; BRG1-associated factor 250a; SWI/SNF complex protein p270; chromatin remodeling factor p250; ARID domain-containing protein 1A; SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin subfamily F member 1;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • E.coli
  • E.Coli or Yeast
  • HEK293
  • Insect Cell
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • His|Myc
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ARID1A-3677H Recombinant Human ARID1A, His-tagged E.Coli or Yeast His 2285
Human ARID1A-792H Recombinant Human ARID1A protein, GST-tagged Wheat Germ GST
Human ARID1A-2488H Recombinant Human ARID1A Protein (1976-2231 aa), His-Myc-tagged E.coli His/Myc 1976-2231 aa
Human ARID1A-2201H Recombinant Human ARID1A protein, His&Myc-tagged Insect Cell His&Myc 1976-2231aa
Human ARID1A-2751H Recombinant Human ARID1A Protein (1976-2231 aa), His-Myc-tagged Insect Cell His/Myc 1976-2231 aa
Human ARID1A-2549H Recombinant Human ARID1A protein, His&Myc-tagged E.coli His&Myc 1976-2231aa
Mouse ARID1A-1909M Recombinant Mouse ARID1A Protein Mammalian Cell His
Mouse Arid1a-3676M Recombinant Mouse Arid1a, His-tagged E.Coli or Yeast His 2283
Mouse ARID1A-705M Recombinant Mouse ARID1A Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse ARID1A-705M-B Recombinant Mouse ARID1A Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • ARID1A Related Articles
  • ARID1A Related Research Area

ARID1A involved in several pathways and played different roles in them. We selected most pathways ARID1A participated on our site, such as Chromatin modifying enzymes, Chromatin organization, Prostate Cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with ARID1A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Chromatin modifying enzymesKDM4C;RBBP4;MBD3;HMG20B;ING3;SUZ12;ATXN7L3;TADA2A;COPRS
Chromatin organizationSMARCD3;KDM5A;TADA3;USP22;KDM6B;SAP30;ING5;SMARCD3B;ENY2
Prostate CancerINS;ERBB2;PIK3R5;MAPK1;PDPK1;TRP53;GRB2;AKT2;TP53
RMTs methylate histone argininesACTL6B;SMARCD1;SMARCD3;SMARCE1;COPRS;ARID1A;SMARCA4;PRMT7;SMARCB1A

ARID1A has several biochemical functions, for example, DNA binding, ligand-dependent nuclear receptor binding, nucleosome binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ARID1A itself. We selected most functions ARID1A had, and list some proteins which have the same functions with ARID1A. You can find most of the proteins on our site.

Function Related Protein
DNA bindingHIST1H2AA;ISL2A;ZNF426;ZNF317;BBX;ZBTB48;ZNF511;PAX3A;IRF7
ligand-dependent nuclear receptor bindingSMARCE1;TRIM24;NR1H4;NCOA2;PROX1;SRA1;NCOA3;SMARCD3;PPARGC1A
nucleosome bindingRNF4;RNF168;ZNHIT1;RNF169;NOC2L;SMARCA5;ARID1A;DNTTIP1;L3MBTL1
protein bindingSOX13;PFKL;SELL;GPX7;PRKCE;ANXA5;DHX38;RHOC;DGCR6L
transcription coactivator activityNR1H3;MED13;CBFB;CRSP7;SETD3;SMARCA4;NR2F1;TAF6L;TAF9

ARID1A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARID1A here. Most of them are supplied by our site. Hope this information will be useful for your research of ARID1A.

SMARCA4

Yoneyama, K; Kojima, S; et al. Proteomic Identification of Autoantibodies in Sera from Patients with Ovarian Cancer as Possible Diagnostic Biomarkers. ANTICANCER RESEARCH 35:881-889(2015).
Yamamoto, H; Watanabe, Y; et al. An updated review of gastric cancer in the next-generation sequencing era: Insights from bench to bedside and vice versa. WORLD JOURNAL OF GASTROENTEROLOGY 20:3927-3937(2014).
  • Q&As
  • Reviews

Q&As (15)

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Are there any clinical trials targeting ARID1A in cancer? 04/16/2023

There are ongoing clinical trials investigating therapeutic strategies in ARID1A-altered cancers; however, direct targeting of ARID1A itself is challenging. These trials focus on exploiting vulnerabilities in ARID1A-deficient tumors or targeting related pathways. For example, trials are evaluating the use of PARP inhibitors, which exploit deficiencies in DNA repair pathways, in ARID1A-mutant ovarian and endometrial cancers. Other trials explore the combination of ARID1A-targeted therapies with immune checkpoint inhibitors or other targeted agents. These trials aim to improve outcomes for patients with ARID1A-altered cancers.

Is ARID1A protein considered essential for normal development and survival? 03/15/2022

Yes, ARID1A is considered essential for normal development and survival. Studies in animal models have shown that loss of ARID1A function during embryonic development results in severe defects and embryonic lethality. In humans, germline mutations affecting both copies of the ARID1A gene lead to a developmental disorder known as Coffin-Siris syndrome. This highlights the critical role of ARID1A in normal development and its importance for survival.

Are there any diseases or disorders associated with mutations in ARID1A? 08/06/2021

Yes, mutations in ARID1A are frequently found in various types of cancer. ARID1A acts as a tumor suppressor and its inactivation or loss-of-function mutations have been implicated in several cancers, including ovarian, endometrial, gastric, and bladder cancers. These mutations can lead to dysregulated gene expression, altered chromatin remodeling, and disrupted cellular processes, fostering tumorigenesis.

What are the known interactions or binding partners of ARID1A protein? 06/03/2021

ARID1A interacts with several proteins involved in chromatin remodeling and transcriptional regulation. Some of its known binding partners include SWI/SNF complex subunits (e.g., BRG1, BRM), transcription factors (e.g., p53, SNAI1, E2F1), and other chromatin-associated proteins (e.g., EZH2, HDAC1). These interactions contribute to the functional roles of ARID1A in modulating chromatin structure and gene expression.

Does ARID1A play a role in other diseases besides cancer? 04/14/2020

ARID1A has primarily been studied in the context of cancer, where its mutations are frequently observed. However, emerging evidence suggests that ARID1A may also have implications in other diseases. Studies have implicated ARID1A in neurological disorders, such as intellectual disability and autism spectrum disorders, as well as in liver diseases like hepatocellular carcinoma and non-alcoholic fatty liver disease. Further research is needed to fully understand the role of ARID1A in these conditions.

Can ARID1A mutations be inherited? 01/03/2020

Yes, ARID1A mutations can be inherited in some cases. Germline mutations in ARID1A have been identified in a small percentage of individuals with certain genetic syndromes, such as the Coffin-Siris syndrome. However, the majority of ARID1A mutations in cancer are somatic, meaning they occur spontaneously during the development of the tumor and are not inherited.

Are there any known therapeutic implications targeting ARID1A protein? 09/29/2019

Targeting ARID1A directly is challenging due to its essential role in normal cellular processes. However, targeting downstream signaling pathways or molecules influenced by ARID1A alterations may hold therapeutic potential. For example, drugs targeting epigenetic modifiers, such as EZH2 inhibitors, have shown promise in ARID1A-mutated cancers. Additionally, exploring synthetic lethal interactions specific to ARID1A-deficient tumors may provide alternative therapeutic strategies in the future.

What are the consequences of ARID1A mutations in cancer? 10/23/2018

ARID1A mutations in cancer can have various consequences. Loss-of-function mutations or inactivation of ARID1A can lead to dysregulated gene expression and altered chromatin remodeling. This can affect cellular processes like DNA repair, cell cycle regulation, and cell differentiation, contributing to tumorigenesis and tumor progression. ARID1A mutations are often associated with aggressive tumor behavior and poor prognosis in certain cancer types.

How common are ARID1A mutations in cancer? 01/16/2018

ARID1A mutations are relatively common in certain types of cancer. They are most frequently observed in endometrial carcinoma, with mutations occurring in approximately 40% of cases. ARID1A mutations are also found in other gynecological cancers, such as ovarian and uterine clear cell carcinoma, with frequencies ranging from 20-60%. Additionally, ARID1A mutations are reported in various other cancer types, including gastric, colorectal, pancreatic, and renal cell carcinoma, albeit at lower frequencies. The prevalence of ARID1A mutations can vary depending on the specific cancer type and individual patient characteristics.

Are there any known drugs or compounds that specifically target ARID1A? 08/24/2017

Currently, there are no drugs or compounds that directly target ARID1A. However, there are ongoing efforts to identify small molecules or inhibitors that can modulate ARID1A function or exploit vulnerabilities in ARID1A-deficient cancers. These approaches aim to indirectly target ARID1A by targeting related pathways or downstream effectors that are dependent on ARID1A activity.

Are there any known natural compounds or dietary factors that can affect ARID1A expression or activity? 03/20/2017

Research on natural compounds or dietary factors specifically targeting ARID1A expression or activity is still limited. However, some studies have investigated the effects of certain compounds or dietary components on ARID1A-related pathways or functions. For example, curcumin, a compound found in turmeric, has been shown to affect ARID1A expression in certain cancers. Resveratrol, a compound found in grapes and red wine, has also been reported to modulate ARID1A expression and activity. However, more research is needed to fully understand the effects of natural compounds or dietary factors on ARID1A and their potential therapeutic implications.

Can ARID1A be targeted for therapeutic intervention? 03/05/2017

Directly targeting ARID1A is difficult due to its essential role in normal cellular processes. However, ongoing research aims to develop therapeutic strategies targeting ARID1A-altered cancers indirectly. This includes exploring synthetic lethal interactions, combination therapies with drugs targeting related pathways or downstream effectors, and exploiting vulnerabilities in ARID1A-deficient tumors. It is an area of active investigation with the potential for future therapeutic advancements.

Are there any known post-translational modifications of ARID1A? 11/20/2016

Yes, several post-translational modifications have been reported for ARID1A. These modifications can regulate its activity, stability, and subcellular localization. For example, phosphorylation of ARID1A by kinases like ATM and ATR can modulate its function in DNA damage response. Furthermore, acetylation, ubiquitination, and SUMOylation have also been observed to impact ARID1A activity.

Is ARID1A expression associated with any prognostic or diagnostic markers in cancer? 09/13/2016

Yes, ARID1A expression has been linked to certain prognostic and diagnostic markers in cancer. In ovarian cancer, loss of ARID1A expression has been associated with higher tumor stage, increased tumor invasiveness, and resistance to chemotherapy. Additionally, ARID1A expression levels have been suggested as a potential diagnostic marker for distinguishing between different subtypes of endometrial cancer.

Can ARID1A mutations be targeted with gene editing technologies such as CRISPR/Cas9? 08/31/2016

Gene editing technologies like CRISPR/Cas9 have the potential to target specific genes, including ARID1A, for precise modifications. While it is theoretically possible to use CRISPR/Cas9 to target and modify ARID1A mutations, there are several challenges associated with this approach. First, efficiently delivering CRISPR/Cas9 components to the desired cells within a tumor can be technically challenging. Second, ARID1A mutations are often heterozygous, meaning they occur on one allele of the gene while the other allele remains normal. In such cases, selectively editing the mutated allele without affecting the normal allele can be difficult. Additionally, the potential off-target effects of CRISPR/Cas9 editing must be carefully assessed to avoid unintended consequences. Further research is needed to optimize gene editing strategies for targeting ARID1A mutations.

Customer Reviews (10)

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Reviews
01/29/2023

    Whether it is regarding experimental design, optimization of protocols, or troubleshooting issues, their expertise and prompt customer service help researchers overcome challenges efficiently.

    04/12/2022

      With the manufacturer's unwavering dedication to delivering quality products and unparalleled technical support, I am confident in their ability to help me overcome any challenges and propel my research forward.

      07/09/2021

        The ARID1A protein offered by the manufacturer is of exceptional quality and is expected to perfectly meet my experimental needs.

        05/02/2021

          the ARID1A protein demonstrates significant relevance and potential in various trial applications, primarily focusing on inflammation, angiogenesis, and tissue remodeling.

          03/13/2021

            Its purity and integrity are of the highest standard, ensuring reliable and reproducible results in my research.

            09/27/2020

              The manufacturer's commitment to providing excellent technical support is commendable, as their dedicated team possesses the expertise to solve any issue or query that may arise during my experiments.

              09/02/2020

                The manufacturer maintains stringent quality control measures to ensure the purity and stability of the protein, minimizing experimental variability and maximizing the accuracy of the data obtained.

                03/14/2019

                  Their prompt assistance and guidance contribute to enhancing the success and efficiency of my work with the ARID1A protein.

                  01/15/2019

                    Another advantage of the ARID1A protein is its reliability and consistency, ensuring robust and reproducible results.

                    11/29/2018

                      the manufacturer's support plays a crucial role in the successful implementation of trials involving the ARID1A protein.

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