Recombinant Human ARID1A Protein (1976-2231 aa), His-Myc-tagged

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Recombinant Human ARID1A Protein (1976-2231 aa), His-Myc-tagged

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Cat.No. : ARID1A-2488H
Product Overview : Recombinant Human ARID1A Protein (1976-2231 aa) is produced by E. coli expression system. This protein is fused with a 10xHis tag at the N-terminal and a Myc tag at the C-terminal. Research Area: Cancer. Protein Description: Partial.
Description : Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Binds DNA non-specifically. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth.
Source : E. coli
Species : Human
Tag : His-Myc
Form : Tris-based buffer,50% glycerol
Molecular Mass : 33.4 kDa
Protein length : 1976-2231 aa
AA Sequence : SLAKRCVCVS NTIRSLSFVP GNDFEMSKHP GLLLILGKLI LLHHKHPERK QAPLTYEKEE EQDQGVSCNK VEWWWDCLEM LRENTLVTLA NISGQLDLSP YPESICLPVL DGLLHWAVCP SAEAQDPFST LGPNAVLSPQ RLVLETLSKL SIQDNNVDLI LATPPFSRLE KLYSTMVRFL SDRKNPVCRE MAVVLLANLA QGDSLAARAI AVQKGSIGNL LGFLEDSLAA TQFQQSQASL LHMQNPPFEP TSVDMM
Purity : > 85% as determined by SDS-PAGE.
Notes : Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week.
Storage : The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade.
Concentration : A hardcopy of COA will be sent along with the products. Please refer to it for detailed information.
Figure :

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Gene Name : ARID1A AT rich interactive domain 1A (SWI-like) [ Homo sapiens ]
Official Symbol : ARID1A
Synonyms : ARID1A; B120; BAF250; BAF250a; C10rf4; P270; osa homolog 1; SWI-like protein; ELD; OSA1; hELD; BM029; hOSA1; C1orf4; SMARCF1;
Gene ID : 8289
mRNA Refseq : NM_006015
Protein Refseq : NP_006006
MIM : 603024
UniProt ID : O14497

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