Recombinant Human ARID1A Protein (1976-2231 aa), His-Myc-tagged
Cat.No. : | ARID1A-2751H |
Product Overview : | Recombinant Human ARID1A Protein (1976-2231 aa) is produced by Baculovirus expression system. This protein is fused with a 10xHis tag at the N-terminal and a Myc tag at the C-terminal. Research Area: Cancer. Protein Description: Partial. |
- Specification
- Gene Information
- Related Products
Description : | Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Binds DNA non-specifically. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. |
Source : | Baculovirus |
Species : | Human |
Tag : | His-Myc |
Form : | Tris-based buffer,50% glycerol |
Molecular Mass : | 32.4 kDa |
Protein length : | 1976-2231 aa |
AA Sequence : | SLAKRCVCVSNTIRSLSFVPGNDFE MSKHPGLLLILGKLILLHHKHPERK QAPLTYEKEEEQDQGVSCNKVEWWW DCLEMLRENTLVTLANISGQLDLSP YPESICLPVLDGLLHWAVCPSAEAQ DPFSTLGPNAVLSPQRLVLETLSKL SIQDNNVDLILATPPFSRLEKLYST MVRFLSDRKNPVCREMAVVLLANLA QGDSLAARAIAVQKGSIGNLLGFLE DSLAATQFQQSQASLLHMQNPPFEP TSVDMM |
Purity : | > 85% as determined by SDS-PAGE. |
Notes : | Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week. |
Storage : | The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade. |
Concentration : | A hardcopy of COA will be sent along with the products. Please refer to it for detailed information. |
Gene Name : | ARID1A AT rich interactive domain 1A (SWI-like) [ Homo sapiens ] |
Official Symbol : | ARID1A |
Synonyms : | ARID1A; B120; BAF250; BAF250a; C10rf4; P270; osa homolog 1; SWI-like protein; ELD; OSA1; hELD; BM029; hOSA1; C1orf4; SMARCF1; |
Gene ID : | 8289 |
mRNA Refseq : | NM_006015 |
Protein Refseq : | NP_006006 |
MIM : | 603024 |
UniProt ID : | O14497 |
Products Types
◆ Recombinant Protein | ||
ARID1A-2488H | Recombinant Human ARID1A Protein (1976-2231 aa), His-Myc-tagged | +Inquiry |
ARID1A-705M | Recombinant Mouse ARID1A Protein, His (Fc)-Avi-tagged | +Inquiry |
ARID1A-3677H | Recombinant Human ARID1A, His-tagged | +Inquiry |
ARID1A-1909M | Recombinant Mouse ARID1A Protein | +Inquiry |
ARID1A-2201H | Recombinant Human ARID1A protein, His&Myc-tagged | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
0
Inquiry Basket