irak3
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  • Official Full Name
  • interleukin-1 receptor-associated kinase 3
  • Background
  • This gene encodes a member of the interleukin-1 receptor-associated kinase protein family. Members of this family are essential components of the Toll/IL-R immune signal transduction pathways. This protein is primarily expressed in monocytes and macrophages and functions as a negative regulator of Toll-like receptor signaling. Mutations in this gene are associated with a susceptibility to asthma. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
  • Synonyms
  • IRAK3; interleukin-1 receptor-associated kinase 3; ASRT5; IRAKM; IL-1 receptor-associated kinase M;
Cat.#:IRAK3-5051HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human IRAK3 Protein, GST-tagged
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Cat.#:IRAK3-7003HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human IRAK3, GST-tagged
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Cat.#:IRAK3-7076HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IRAK3 protein, His-tagged
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Cat.#:IRAK3-5170HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human IRAK3 293 Cell Lysate
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Involved Pathway

IRAK3 involved in several pathways and played different roles in them. We selected most pathways IRAK3 participated on our site, such as Activated TLR4 signalling, Apoptosis, Cytokine Signaling in Immune system, which may be useful for your reference. Also, other proteins which involved in the same pathway with IRAK3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Activated TLR4 signalling
APPA; CHST13; DUSP6; AGER; MAPK14; TICAM1; TAB1; S100B; DHX9; JUN
Apoptosis
BIDA; TRADD; NFKBIA; CAPN2A; PIK3R3; CTNNB1; RIPK1L; PKP1; APAF1; DCC
Cytokine Signaling in Immune system
DUSP2; IFI27; KPNA4; TNFRSF13C; NRG4; CSH1; DUSP1; DAB2IPB; FCGR1B; WDR83
IL1-mediated signaling events
IL1RN; TMED7-TICAM2; TMEM189-UBE2V1; IRAK3
Immune System
MX2; AMICA1; CNPY3; SPSB2; WIPF3; NCKAP1; EDARADD; RNF138; MICA; IFIT14
Innate Immune System
KIR3DS1; BTR22; CFHL4; CLEC5A; NLRP4E; TXNIPB; IFI16; MGC174857; TNIP2; DEFB125
Interleukin-1 signaling
TNIP2; IRAK3; IL1RN; NOD1; PELI3; PELI2; PELI1
MyD88:Mal cascade initiated on plasma membrane
IRAK3; SIGIRR

Protein Function

IRAK3 has several biochemical functions, for example, ATP binding, magnesium ion binding, protein heterodimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by IRAK3 itself. We selected most functions IRAK3 had, and list some proteins which have the same functions with IRAK3. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein UBE2G2; NWD1; DDX5; MYLK; ABCB3L1; ABCD3B; ATP13A1; HSPA9; ULK1A; PMVK
Function magnesium ion binding
Related Protein PGP; RPS6KA1; LATS1; SIK3; ATP9B; ARF1; DUT; PPM1BB; MAPK12; ADSS
Function protein heterodimerization activity
Related Protein IKZF1; DMBX1; UNC13A; SNX1; CD3G; ATF3; TENM1; RRAGC; PANX2; KATNB1
Function protein homodimerization activity
Related Protein TP53I3; CITED1; LRRK2; S100A11; KLHL7; NOG; PAFAH1B2; ACCS; SRGAP2A; RENBP
Function protein serine/threonine kinase activity
Related Protein TRPM6; CSNK1E; TESK2; CDC42BPG; TTBK1; NEK10; ADCK2; DYRK3; ROCK1; SNRK

Interacting Protein

IRAK3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IRAK3 here. Most of them are supplied by our site. Hope this information will be useful for your research of IRAK3.
IRAK2; IRAK1; CD14; HOXB7; HSP90AB1; MYD88; TRAF6; NSA2; ADH1B; FOLR1; COPB1; NONO; NTRK3