Recombinant Full Length Human IRAK3 Protein, C-Flag-tagged

• Cat.No.: IRAK3-1792HFL
• Product Overview: Recombinant Full Length Human IRAK3 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: This gene encodes a member of the interleukin-1 receptor-associated kinase protein family. Members of this family are essential components of the Toll/IL-R immune signal transduction pathways. This protein is primarily expressed in monocytes and macrophages and functions as a negative regulator of Toll-like receptor signaling. Mutations in this gene are associated with a susceptibility to asthma. Alternate splicing results in multiple transcript variants.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 67.6 kDa
• AA Sequence: MAGNCGARGALSAHTLLFDLPPALL GELCAVLDSCDGALGWRGLAERLSS SWLDVRHIEKYVDQGKSGTR ELLWSWAQKNKTIGDLLQVLQEMGH RRAIHLITNYGAVLSPSEKSYQEGG FPNILFKETANVTVDNVLIP EHNEKGVLLKSSISFQNIIEGTRNF HKDFLIGEGEIFEVYRVEIQNLTYA VKLFKQEKKMQCKKHWKRFL SELEVLLLFHHPNILELAAYFTETE KFCLIYPYMRNGTLFDRLQCVGDTA PLPWHIRIGILIGISKAIHY LHNVQPCSVICGSISSANILLDDQF QPKLTDFAMAHFRSHLEHQSCTINM TSSSSKHLWYMPEEYIRQGK LSIKTDVYSFGIVIMEVLTGCRVVL DDPKHIQLRDLLRELMEKRGLDSCL SFLDKKVPPCPRNFSAKLFC LAGRCAATRAKLRPSMDEVLNTLES TQASLYFAEDPPTSLKSFRCPSPLF LENVPSIPVEDDESQNNNLL PSDEGLRIDRMTQKTPFECSQSEVM FLSLDKKPESKRNEEACNMPSSSCE ESWFPKYIVPSQDLRPYKVN IDPSSEAPGHSCRSRPVESSCSSKF SWDEYEQYKKE TRTRPLEQKLISEEDLAANDILDYK DDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome, Protein Kinase
• Protein Pathways: Apoptosis, Neurotrophin signaling pathway

Gene Information

• Gene Name: IRAK3 interleukin 1 receptor associated kinase 3 [ Homo sapiens (human) ]
• Official Symbol: IRAK3
• Synonyms: ASRT5; IRAKM
• Gene ID: 11213
• mRNA Refseq: NM_007199.3
• Protein Refseq: NP_009130.2
• MIM: 604459
• UniProt ID: Q9Y616