Recombinant Human IRAK3, GST-tagged

• Cat.No.: IRAK3-7003H
• Product Overview: Recombinant full-length human IRAK3 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Specification

• Description: IRAK3 or interleukin-1 receptor-associated kinase 3 is a member of the interleukin-1 receptor-associated kinase protein family which is essential components of the Toll/IL-R immune signal transduction pathways. IRAK3 is primarily expressed in monocytes and macrophages and functions as a negative regulator of Toll-like receptor signaling. IRAKM mediates critical aspects of innate immunity that result in an immunocompromised state during sepsis. Mutations in IRAK3 are associated with a susceptibility to asthma.
• Source: Sf9 Cells
• Species: Human
• Tag: GST
• Form: Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 50mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
• Molecular Mass: ~96 kDa
• Protein length: Full length
• Purity: >80%
• Applications: Western Blot
• Storage: Store at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. Avoid freeze/thaw cycles.
• Concentration: 0.1 μg/μl

Gene Information

• Gene Name: IRAK3 interleukin-1 receptor-associated kinase 3 [ Homo sapiens ]
• Official Symbol: IRAK3
• Synonyms: IRAK3; interleukin-1 receptor-associated kinase 3; IRAK M; IL-1 receptor-associated kinase M; ASRT5; IRAKM; FLJ13601
• Gene ID: 11213
• mRNA Refseq: NM_001142523
• Protein Refseq: NP_001135995
• MIM: 604459
• UniProt ID: Q9Y616
• Chromosome Location: 12q13.13
• Pathway: Activated TLR4 signalling, organism-specific biosystem; Apoptosis, organism-specific biosystem; Apoptosis, conserved biosystem; Cytokine Signaling in Immune system, organism-specific biosystem; IL1-mediated signaling events, organism-specific biosystem; Immune System, organism-specific biosystem; Innate Immune System, organism-specific biosystem
• Function: ATP binding; magnesium ion binding; nucleotide binding; protein binding; protein heterodimerization activity; protein homodimerization activity; protein serine/threonine kinase activity