Recombinant Human IRAK3 Protein, GST-tagged

• Cat.No.: IRAK3-5051H
• Product Overview: Human IRAK3 full-length ORF ( AAH57800, 1 a.a. - 596 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: This gene encodes a member of the interleukin-1 receptor-associated kinase protein family. Members of this family are essential components of the Toll/IL-R immune signal transduction pathways. This protein is primarily expressed in monocytes and macrophages and functions as a negative regulator of Toll-like receptor signaling. Mutations in this gene are associated with a susceptibility to asthma. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 91.3 kDa
• AA Sequence: MAGNWGARGALSAHTLLFDLPPALL GELCAVLDSCDGALGWRGLAERLSS SRLDVRHIEKYVDQGKSGTRELLWS WAQKNKTIGDLLQVLQEMGHRRAIH LITNYGAVLSPSEKSYQEGGFPNIL FKETANVTVDNVLIPEHNEKGVLLK SSISFQNIIEGTRNFHKDFLIGEGE IFEVYRVEIQNLTYAVKLFKQEKKM QCKKHWKRFLSELEALLLFHHPSIL ELAAYFTETEKFCLIYPYMRNGTLF DRLQCVGDTAPLPWHIRIGILIGIS KAIHYLHNVQPCSVICGSISSANIL LDDQFQPKLTDFAMAHFRSHLEHQS CTINMTSSSSKHLWYMPEEYIRQGK LSIKTDVYSFGIVIMEVLTGCRVVL DDPKHIQLRDLLRELMEKRGLDSCL SFLDKKVPPCPRNFSAKLFCLAGRC AATRAKLRPSMDEVLNTLESTQASL YFAEDPPTSLKSFRCPSPLFLENVP SIPVEDDESQNNNLLPSDEGLRIDR MTQKTPFECSQSEVMFLSLDKKPES KRNEEACNMPSSSCEESWFPKYIVP SQDLRPYKVNIDPSSEAPGHSCRSR PVESSCSSKFSWDEYEQYKKE
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: IRAK3 interleukin-1 receptor-associated kinase 3 [ Homo sapiens ]
• Official Symbol: IRAK3
• Synonyms: IRAK3; interleukin-1 receptor-associated kinase 3; IRAK M; IL-1 receptor-associated kinase M; ASRT5; IRAKM; FLJ13601
• Gene ID: 11213
• mRNA Refseq: NM_001142523
• Protein Refseq: NP_001135995
• MIM: 604459
• UniProt ID: Q9Y616