itgb8
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  • Official Full Name
  • integrin, beta 8
  • Background
  • This gene is a member of the integrin beta chain family and encodes a single-pass type I membrane protein with a VWFA domain and four cysteine-rich repeats. This protein noncovalently binds to an alpha subunit to form a heterodimeric integrin complex. In general, integrin complexes mediate cell-cell and cell-extracellular matrix interactions and this complex plays a role in human airway epithelial proliferation. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.
  • Synonyms
  • ITGB8; integrin, beta 8; integrin beta-8; ITGB 8; OTTHUMP00000025212
Cat.#:ITGB8-2220RTag:His
Source (Host):YeastSpecies:Rabbit
Product nameRecombinant Rabbit ITGB8 Protein, His-tagged
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Cat.#:ITGB8-2297RTag:His/Myc
Source (Host):E. coliSpecies:Rabbit
Product nameRecombinant Rabbit ITGB8 Protein (146-384 aa), His-Myc-tagged
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Cat.#:ITGB8-255HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ITGB8 Protein, His-tagged
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Cat.#:ITGB8-4964HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human ITGB8 Protein, GST-tagged
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Cat.#:ITGB8-183HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ITGB8, GST-tagged
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Cat.#:ITGB8-2317RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey ITGB8 Protein, His-tagged
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Cat.#:ITGB8-881HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human ITGB8 cell lysate
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Involved Pathway

ITGB8 involved in several pathways and played different roles in them. We selected most pathways ITGB8 participated on our site, such as PIK-Akt signaling pathway, Focal adhesion, ECM-receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with ITGB8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
PIK-Akt signaling pathway
COL6A6; INS1; TCL1B; VEGFC; PIK3R3; THBS3; PDGFB; HSP90AA1; VEGFA; FGF14
Focal adhesion
PPP1R12B; SOS1; FN1; THBS4B; ITGB1; COL6A5; THBS3A; MLCK2; IGF1RA; BCL2A
ECM-receptor interaction
Reln; ITGA8; ITGB1; COL6A5; COL4A3; ITGA5; GP1BA; ITGB4; ITGA9; ITGA2B
Cell adhesion molecules (CAMs)
ITGB2L; CLDN6; NEGR1; CLDN19; CLDNJ; CNTNAP1; CLDN11A; ICOS; HLA-DRA; CNTNAP2A
Regulation of actin cytoskeleton
FGFR1A; ITGA6; PAK3; DIAPH3; ARHGEF4; ITGB3; ITGA9; INS2; FGD1; ITGB3B
Hypertrophic cardiomyopathy (HCM)
ITGA8; ACTG1; ITGA5; CACNG3; TPM3; ITGB3; ITGB6; ATP2A2; ITGB5; ITGA2
Arrhythmogenic right ventricular cardiomyopathy (ARVC)
ACTN1; CACNA2D3; LMNA; CACNG2; LEF1; ITGB5; ACTN2; ITGA9; ITGA4; CACNA2D4
Dilated cardiomyopathy
TNNI3; TPM2; CACNG3; TGFB1; ITGB4; EMD; ACTB; TPM1; CACNG2; SGCD

Protein Function

ITGB8 has several biochemical functions, for example, extracellular matrix protein binding, receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ITGB8 itself. We selected most functions ITGB8 had, and list some proteins which have the same functions with ITGB8. You can find most of the proteins on our site.
Function
Related Protein
Function extracellular matrix protein binding
Related Protein ITGAV; ITGB8; MEPE
Function receptor activity
Related Protein AMHR2; ERBB3B; VMN1R46; MCC; P2RY1; NRP2; SLC40A1; BTLA; VMN1R52; DERL1

Interacting Protein

ITGB8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ITGB8 here. Most of them are supplied by our site. Hope this information will be useful for your research of ITGB8.
ITGAV