LPL

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LPL

Official Full Name Lipoprotein Lipase
Background LPL encodes lipoprotein lipase, which is expressed in heart, muscle, and adipose tissue. LPL functions as a homodimer, and has the dual functions of triglyceride hydrolase and ligand/bridging factor for receptor-mediated lipoprotein uptake. Severe mutations that cause LPL deficiency result in type I hyperlipoproteinemia, while less extreme mutations in LPL are linked to many disorders of lipoprotein metabolism.
Synonyms LIPD; HDLCQ11; EC 3.1.1.34; LPL; lipoprotein lipase; MGC137861; OTTHUMP00000034806
    • Species :
    • Chicken
    • Cynomolgus Monkey
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • CHO
    • E.coli
    • HEK293
    • HEK293T
    • Insect Cell
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • Flag
    • GST
    • His
    • His/Myc
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human LPL-22H  Recombinant Human LPL Protein, His-tagged CHO His
    Mouse Lpl-1335M Recombinant Mouse Lpl Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Mouse LPL-379M Recombinant Mouse LPL protein, His-tagged Insect Cell His
    Mouse LPL-388M Recombinant Mouse LPL protein, His & Myc-tagged E.coli His/Myc
    Mouse LPL-389M Recombinant Mouse LPL protein E.coli His
    Human LPL-5717H Recombinant Human LPL Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human LPL-1014H Recombinant Human LPL, His-tagged E.coli his
    Human LPL-1015H Recombinant Human LPL protein, Flag-tagged HEK293 Flag
    Human LPL-27722TH Recombinant Human LPL, FLAG-tagged HEK293 Flag
    Human LPL-4665HCL Recombinant Human LPL 293 Cell Lysate HEK293 N/A
    Human LPL-4715H Recombinant Human LPL Protein, GST-tagged Wheat Germ GST
    Human LPL-556H Recombinant Human LPL Protein, His-tagged E.coli His
    Mouse LPL-9205M Recombinant Mouse LPL Protein Mammalian Cell His
    Rat LPL-3443R Recombinant Rat LPL Protein Mammalian Cell His
    Rat Lpl-557R Recombinant Rat Lpl Protein, His-tagged E.coli His
    Cynomolgus Monkey LPL-658C Recombinant Cynomolgus LPL Protein, His-tagged Mammalian Cell His
    Chicken LPL-6834C Recombinant Chicken LPL Mammalian Cell His
    Zebrafish LPL-8750Z Recombinant Zebrafish LPL Mammalian Cell His
    Kit-0521 Lipoprotein Lipase Activity Fluorometric Assay Kit N/A

    LPL involved in several pathways and played different roles in them. We selected most pathways LPL participated on our site, such as Glycerolipid metabolism, PPAR signaling pathway, Alzheimers disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with LPL were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Glycerolipid metabolism ALDH9A1B; LIPC; ALDH9A1; AGK; LPIN2; PNLIPRP3; ALDH1B1; PNLIPRP1; MBOAT2B; LCLAT1
    PPAR signaling pathway MMP1A; APOA1; ACAA1A; RXRGB; PPARDB; PPARD; FABP2; RXRA; CYP4A12A; ACSL1
    Alzheimers disease NDUFAB1; GRIN2B; MAPK1; NDUFA3; ITPR3; ATP5H; NDUFV3; NDUFA13; APOE; MT-ATP6

    LPL has several biochemical functions, for example, apolipoprotein binding, heparin binding, lipoprotein lipase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by LPL itself. We selected most functions LPL had, and list some proteins which have the same functions with LPL. You can find most of the proteins on our site.

    Function Related Protein
    apolipoprotein binding LPL; PCSK9; VLDLR; SCARB1; PLG; CANX; LRP1; LRP6; LPA; MAPT
    heparin binding LAMC2; SLIT1B; LRPAP1; LPL; VTN; MMP7; CTGFB; OGN; ANG; CXCL11
    lipoprotein lipase activity LPL; LIPG; AOAH
    phospholipase activity Cel; NOTUM1A; LIPN; Aadacl3; LIPC; LPL; LIPM; ABHD6; PLA2G10; ABHD2A
    protein binding CARF; EIF3I; C7orf59; MARK3; CD69; TMEM79; MCRS1; CENPO; ANK2; EFCAB11
    receptor binding CNPY4; FGF10A; DPP4; MCHR1; TNFSF13; IL29; RSPO3; REN; POMC; Icosl
    triglyceride binding LPL; CETP
    triglyceride lipase activity LIPCA; PNLIPRP1; PNPLA3; Cel; PNLIPRP2; CEL.1; PNPLA2; CES1D; LIPF; LIPC

    LPL has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LPL here. Most of them are supplied by our site. Hope this information will be useful for your research of LPL.

    APOA5; SORT1; GPIHBP1; CCND1; PTPN4; RPL18A; COPS6; ASCC2; UBE2Z; CEP126; LUC7L2; PLK1

    Beigneux, AP; Fong, LG; et al. GPIHBP1 Missense Mutations Often Cause Multimerization of GPIHBP1 and Thereby Prevent Lipoprotein Lipase Binding. CIRCULATION RESEARCH 116:624-U152(2015).
    Toth-Liptak, J; Piukovics, K; et al. A Comprehensive Immunophenotypic Marker Analysis of Hairy Cell Leukemia in Paraffin-Embedded Bone Marrow Trephine Biopsies-A Tissue Microarray Study. PATHOLOGY & ONCOLOGY RESEARCH 21:203-211(2015).

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