lpl
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  • Official Full Name
  • Lipoprotein Lipase
  • Background
  • LPL encodes lipoprotein lipase, which is expressed in heart, muscle, and adipose tissue. LPL functions as a homodimer, and has the dual functions of triglyceride hydrolase and ligand/bridging factor for receptor-mediated lipoprotein uptake. Severe mutations that cause LPL deficiency result in type I hyperlipoproteinemia, while less extreme mutations in LPL are linked to many disorders of lipoprotein metabolism.
  • Synonyms
  • LIPD; HDLCQ11; EC 3.1.1.34; LPL; lipoprotein lipase; MGC137861; OTTHUMP00000034806
Cat.#:LPL-4715HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human LPL Protein, GST-tagged
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Cat.#:LPL-1014HTag:his
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human LPL, His-tagged
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Cat.#:LPL-1015HTag:Flag
Source (Host):HEK293Species:Human
Product nameRecombinant Human LPL protein, Flag-tagged
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Cat.#:LPL-27722THTag:Flag
Source (Host):HEK293Species:Human
Product nameRecombinant Human LPL, FLAG-tagged
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Cat.#:LPL-556HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human LPL Protein, His-tagged
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Cat.#:LPL-9205MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse LPL Protein
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Cat.#:LPL-3443RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat LPL Protein
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Cat.#:Lpl-557RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Lpl Protein, His-tagged
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Cat.#:LPL-658CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus LPL Protein, His-tagged
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Cat.#:LPL-6834CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken LPL
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Cat.#:LPL-8750ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish LPL
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Cat.#:LPL-4665HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human LPL 293 Cell Lysate
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Cat.#:Kit-0521Tag:
Source (Host):Species:
Product nameLipoprotein Lipase Activity Fluorometric Assay Kit
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Involved Pathway

LPL involved in several pathways and played different roles in them. We selected most pathways LPL participated on our site, such as Glycerolipid metabolism, PPAR signaling pathway, Alzheimers disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with LPL were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Glycerolipid metabolism
AKR1B1L; CELL; MBOAT2B; ALDH2.1; DGKA; STIL; ALDH3A2; GPAT2; AGPAT4; AGPAT9
PPAR signaling pathway
RXRG; FABP1; PCK1; ILK; ADIPOQB; ACSL1; UCP1; Scd1; FABP3; ACADL
Alzheimers disease
BID; NDUFA11; TNFRSF1A; NDUFB10; NDUFB5; COX8A; NCSTN; NDUFB8; NDUFA9; ATP5J

Protein Function

LPL has several biochemical functions, for example, apolipoprotein binding, heparin binding, lipoprotein lipase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by LPL itself. We selected most functions LPL had, and list some proteins which have the same functions with LPL. You can find most of the proteins on our site.
Function
Related Protein
Function apolipoprotein binding
Related Protein LRP4; ABCA1; LPA; SCARB1; VLDLR; PLG; PCSK9; LIPC; MAPT; LRP1
Function heparin binding
Related Protein COL20A1; RPL29; CECR1; NAV2; PDCD5; COL5A1; VTN; SERPINC1; WISP1; ITGAM
Function lipoprotein lipase activity
Related Protein AOAH; LIPG; LPL
Function phospholipase activity
Related Protein LPL; LIPC; LIPM; PLA2G4AA; NOTUM1A; PNLIPRP2; PNPLA7; PLA2G10; CEL.1; ABHD2B
Function protein binding
Related Protein DPEP1; NPDC1; CTDSP1; KIF9; PSMA4; RNF5; ARRB1; TEX13A; PTK2B; RAP1A
Function receptor binding
Related Protein PTK2BB; DAO1; PLXNC1; PTK2AA; SELPLG; RSPO1; GFRA1; SERPINE2; FGF20B; MPV17L
Function triglyceride binding
Related Protein LPL; CETP
Function triglyceride lipase activity
Related Protein LIPE; LIPC; PNLIPRP2; Cel; PNLIPRP1; CES1D; PNLIPRP3; CES1; PNPLA2; PNLIP

Interacting Protein

LPL has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LPL here. Most of them are supplied by our site. Hope this information will be useful for your research of LPL.
APOA5; SORT1; GPIHBP1; CCND1; PTPN4; RPL18A; COPS6; ASCC2; UBE2Z; CEP126; LUC7L2; PLK1

LPL Related Articles

Beigneux, AP; Fong, LG; et al. GPIHBP1 Missense Mutations Often Cause Multimerization of GPIHBP1 and Thereby Prevent Lipoprotein Lipase Binding. CIRCULATION RESEARCH 116:624-U152(2015).
Toth-Liptak, J; Piukovics, K; et al. A Comprehensive Immunophenotypic Marker Analysis of Hairy Cell Leukemia in Paraffin-Embedded Bone Marrow Trephine Biopsies-A Tissue Microarray Study. PATHOLOGY & ONCOLOGY RESEARCH 21:203-211(2015).