Recombinant Human LPL, FLAG-tagged
| Cat.No. : | LPL-27722TH |
| Product Overview : | Recombinant Full length Human Lipoprotein lipase with an N terminal DDDDK tag; 461 amino acids, MWt 51.8kDa. |
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| Species : | Human |
| Source : | HEK293 |
| Tag : | Flag |
| Protein Length : | 448 amino acids |
| Description : | LPL encodes lipoprotein lipase, which is expressed in heart, muscle, and adipose tissue. LPL functions as a homodimer, and has the dual functions of triglyceride hydrolase and ligand/bridging factor for receptor-mediated lipoprotein uptake. Severe mutations that cause LPL deficiency result in type I hyperlipoproteinemia, while less extreme mutations in LPL are linked to many disorders of lipoprotein metabolism. |
| Conjugation : | FLAG |
| Molecular Weight : | 51.800kDa inclusive of tags |
| Form : | Lyophilised:Add deionized water to prepare a working stock solution of approximately 0.5 mg/mL and let the lyophilized pellet dissolve completely. Aliquot reconstituted protein to avoid repeated freezing/thawing cycles and store at –80°C for long term sto |
| Purity : | Densitometry |
| Storage buffer : | pH: 7.50Constituents:0.24% Tris buffer, 0.29% Sodium chloride |
| Storage : | Store at -80°C |
| Sequences of amino acids : | HVDYKDDDDKPAGADQRRDFIDIESKFALRTPEDTAEDTC HLIPGVAESVATCHFNHSSKTFMVIHGWTVTGMYESWVPK LVAALYKREPDSNVIVVDWLSRAQEHYPVSAGYTKLVGQD VARFINWMEEEFNYPLDNVHLLGYSLGAHAAGIAGSLTNK KVNRITGLDPAGPNFEYAEAPSRLSPDDADFVDVLHTFTR GSPGRSIGIQKPVGHVDIYPNGGTFQPGCNIGEAIRVIAE RGLGDVDQLVKCSHERSIHLFIDSLLNEENPSKAYRCSSK EAFEKGLCLSCRKNRCNNLGYEISKVRAKRSSKMYLKTRS QMPYKVFHYQVKIHFSGTESETHTNQAFEISLYGTVAESE NIPFTLPEVSTNKTYSFLIYTEVDIGELLMLKLKWKSDSY FSWSDWWSSPGFAIQKIRVKAGETQKKVIFCSREKVSHLQ KGKAPAVFVKCHDKSLNKKSG |
| Sequence Similarities : | Belongs to the AB hydrolase superfamily. Lipase family.Contains 1 PLAT domain. |
| Gene Name | LPL lipoprotein lipase [ Homo sapiens ] |
| Official Symbol | LPL |
| Synonyms | LPL; lipoprotein lipase; LIPD; |
| Gene ID | 4023 |
| mRNA Refseq | NM_000237 |
| Protein Refseq | NP_000228 |
| Uniprot ID | P06858 |
| Chromosome Location | 8p22 |
| Pathway | Adipogenesis, organism-specific biosystem; Alzheimers disease, organism-specific biosystem; Alzheimers disease, conserved biosystem; Chylomicron-mediated lipid transport, organism-specific biosystem; Developmental Biology, organism-specific biosystem; |
| Function | heparin binding; hydrolase activity; lipoprotein lipase activity; lipoprotein lipase activity; lipoprotein lipase activity; |
Not For Human Consumption!
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