Recombinant Full Length Human LPL Protein, C-Flag-tagged

• Cat.No.: LPL-107HFL
• Product Overview: Recombinant Full Length Human LPL Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: LPL encodes lipoprotein lipase, which is expressed in heart, muscle, and adipose tissue. LPL functions as a homodimer, and has the dual functions of triglyceride hydrolase and ligand/bridging factor for receptor-mediated lipoprotein uptake. Severe mutations that cause LPL deficiency result in type I hyperlipoproteinemia, while less extreme mutations in LPL are linked to many disorders of lipoprotein metabolism.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 50.3 kDa
• AA Sequence: MESKALLVLTLAVWLQSLTASRGGV AAADQRRDFIDIESKFALRTPEDTA EDTCHLIPGVAESVATCHFN HSSKTFMVIHGWTVTGMYESWVPKL VAALYKREPDSNVIVVDWLSRAQEH YPVSAGYTKLVGQDVARFIN WMEEEFNYPLDNVHLLGYSLGAHAA GIAGSLTNKKVNRITGLDPAGPNFE YAEAPSRLSPDDADFVDVLH TFTRGSPGRSIGIQKPVGHVDIYPN GGTFQPGCNIGEAIRVIAERGLGDV DQLVKCSHERSIHLFIDSLL NEENPSKAYRCSSKEAFEKGLCLSC RKNRCNNLGYEINKVRAKRSSKMYL KTRSQMPYKVFHYQVKIHFS GTESETHTNQAFEISLYGTVAESEN IPFTLPEVSTNKTYSFLIYTEVDIG ELLMLKLKWKSDSYFSWSDW
  WSSPGFAIQKIRVKAGETQKKVIFC SREKVSHLQKGKAPAVFVKCHDKSL NKKSGTRTRPLEQKLISEEDLAAND ILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome
• Protein Pathways: Alzheimer's disease, Glycerolipid metabolism, PPAR signaling pathway

Gene Information

• Gene Name: LPL lipoprotein lipase [ Homo sapiens (human) ]
• Official Symbol: LPL
• Synonyms: LIPD; HDLCQ11
• Gene ID: 4023
• mRNA Refseq: NM_000237.3
• Protein Refseq: NP_000228.1
• MIM: 609708
• UniProt ID: P06858