nek1
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  • Official Full Name
  • NIMA (never in mitosis gene a)-related kinase 1
  • Background
  • The protein encoded by this gene is a serine/threonine kinase involved in cell cycle regulation. The encoded protein is found in a centrosomal complex with FEZ1, a neuronal protein that plays a role in axonal development. Defects in this gene are a cause of polycystic kidney disease (PKD). Several transcript variants encoding different isoforms have been found for this gene.
  • Synonyms
  • NEK1; NIMA (never in mitosis gene a)-related kinase 1; serine/threonine-protein kinase Nek1; KIAA1901; NY REN 55; nimA-related protein kinase 1; protein-serine/threonine kinase; renal carcinoma antigen NY-REN-55; never in mitosis A-related kinase 1; SRPS2
Cat.#:NEK1-29277THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human NEK1
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Cat.#:NEK1-705HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human NEK1
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Cat.#:NEK1-1437MTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Mouse
Product nameRecombinant Mouse NEK1 (Active), GST-tagged
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Protein Function

NEK1 has several biochemical functions, for example, ATP binding, kinase activity, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NEK1 itself. We selected most functions NEK1 had, and list some proteins which have the same functions with NEK1. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein RIMKLA; KIF19; ATP8B5; CAMK2B; SMYHC3; UBE2G2; ABCC1; KDRL; RECQL5; SGK196
Function kinase activity
Related Protein SRPK1A; CDKN1D; CKBA; TGFBR1A; PKMB; EPHA2A; SRPK1B; GRK7A; CDKN1BB; EK1
Function metal ion binding
Related Protein ZYMND12; PPP6C; GGPS1; CTDSP1; DMRT3A; ZFPL1; ZNF706; ACVR2A; ZNF549; SFTPBB
Function protein binding
Related Protein RPLP0; MLLT10; APOBEC1; SRSF10; SLC25A6; ANKRD10; JUP; C22orf39; MGAT5B; PAN3
Function protein kinase activity
Related Protein CAMK2D2; CAMKK1B; CAMK1DB; MINK1; LRRK2; IGF1RB; MKNK2A; EPHB4B; CAMK2D1; RPS6KA3
Function protein serine/threonine kinase activity
Related Protein PKN2; PRKCE; CHEK2; ADCK4; DYRK2; MKNK1; RPS6KB1B; GSK3B; TGFBR1A; SLK
Function protein tyrosine kinase activity
Related Protein FGFR1A; INSRB; SHC1; WEE2; BTK; ERBB4A; TTK; BAZ1B; TEK; EPHB4B

Interacting Protein

NEK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NEK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of NEK1.
LRRK2; FEZ1; FEZ2; saicar; PKM; LRRK1; ATRX; TSC2; MRE11A; YWHAH; TP53BP1; PPP2R5D; ZNF350; EXOSC4