pick1
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  • Official Full Name
  • protein interacting with PRKCA 1
  • Background
  • The protein encoded by this gene contains a PDZ domain, through which it interacts with protein kinase C, alpha (PRKCA). This protein may function as an adaptor that binds to and organizes the subcellular localization of a variety of membrane proteins. It has been shown to interact with multiple glutamate receptor subtypes, monoamine plasma membrane transporters, as well as non-voltage gated sodium channels, and may target PRKCA to these membrane proteins and thus regulate their distribution and function. This protein has also been found to act as an anchoring protein that specifically targets PRKCA to mitochondria in a ligand-specific manner. Three transcript variants encoding the same protein have been found for this gene.
  • Synonyms
  • PICK1; protein interacting with PRKCA 1; PRKCABP, protein interacting with PRKCA , protein kinase C, alpha binding protein; PRKCA-binding protein; dJ1039K5; MGC15204; OTTHUMP00000028509; PICK 1; PICK1_HUMAN; PRKCA binding protein; PRKCABP; Protein interacting with C kinase 1; Protein interacting with PRKCA; Protein kinase C alpha binding protein; Protein kinase C-alpha-binding protein; Protein that interacts with C kinase 1; OTTHUMP00000199277; OTTHUMP00000199289; OTTHUMP00000199291; PICK
Cat.#:Pick1-5636MTag:His/T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Pick1 protein, His & T7-tagged
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Cat.#:PICK1-4445RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PICK1 Protein
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Cat.#:PICK1-3423RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey PICK1 Protein, His-tagged
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Cat.#:PICK1-4692ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish PICK1
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Cat.#:PICK1-3198HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PICK1 293 Cell Lysate
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Involved Pathway

PICK1 involved in several pathways and played different roles in them. We selected most pathways PICK1 participated on our site, such as Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity, Neuronal System, Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell, which may be useful for your reference. Also, other proteins which involved in the same pathway with PICK1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity
NSFA; AKAP5; NSFB; MYO6; GRIP1; HAND2; CACNG3; CACNG2; PICK1
Neuronal System
KCNN4; KCNN3; CHRND; SLC17A7A; KCNA6; SNAP25B; CPLX1; CACFD1; KCNQ3; GLS2B
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
NCALDA; CHRNA5; NSFB; CAMKK1B; CHRNA2; CHRND; DLG1L; PICK1; GABRR2A; MYO6
Trafficking of AMPA receptors
PICK1; HAND2; GRIP1
Trafficking of GluR2-containing AMPA receptors
PICK1; HAND2; GRIP1
Transmission across Chemical Synapses
PICK1; BZRAP1; GRIP1; SYN2; LIN7B; CPLX2L; ARL6IP5A; SLC6A11; ARL6IP5B; SLC1A3B

Protein Function

PICK1 has several biochemical functions, for example, ATPase activity, Arp2/3 complex binding, G-protein coupled receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PICK1 itself. We selected most functions PICK1 had, and list some proteins which have the same functions with PICK1. You can find most of the proteins on our site.
Function
Related Protein
Function ATPase activity
Related Protein ATP13A3; KIFC2; IDE; HSP90AA1; PSMC1; KIFC3; KIF23; VPS4A; ABCF1; CLPB
Function Arp2/3 complex binding
Related Protein HAND2; GMFB; GMFG; ARPC2; WHAMM; CORO1B; SNX9; PICK1
Function G-protein coupled receptor binding
Related Protein RSPO3; PICK1; INSL3; QRFP; FCN1; USP20; GNA11B; ITGB4; GPRC5B; SAA1
Function actin filament binding
Related Protein MYO18A; DBNLB; WIPF1A; FSCN2A; PANX1; MYH9A; ARPC1A; FSCN3; CTNNA2; LCP1
Function enzyme binding
Related Protein STC2; BRCA1; TRIO; SIRT1; KPNB1; RCOR2; RPS3; NLRP1; CYB5A; CD4
Function identical protein binding
Related Protein CCL3; PTPRM; CDC42BPA; CALHM1; MCIN; VIL1; KCNJ10; LCK; BTK; DVL2
Function metal ion binding
Related Protein NAALADL1; TSHZ3; RHOV; TET3; ZDHHC22; ALKBH5; ZDHHC13; PTGS2; RNF128A; ATF7
Function protein C-terminus binding
Related Protein CORO1A; PDZD3; PPP1R9B; MIF4GD; MKI67; PEX26; FIGN; ARL6IP5; TOP2B; YWHAQ
Function protein binding
Related Protein NRAP; SELP; FAM58A; ZG16; RNF168; TNNI1; GIP; ADAMTS13; SLC14A2; TLR1
Function protein domain specific binding
Related Protein BASP1; ETV6; HNRNPM; HIST1H4D; ARL1; CASKIN1; HIST1H4E; EHD2; AKAP1; SLC34A2
Function protein kinase C binding
Related Protein TWF2; UGT1A7; SDPRB; AVPR1A; LDB3; DACT1; GLRX3; GRK5; PRKCSH; PARD3
Function receptor binding
Related Protein FGG; TMED1; PTPRD; TGFB2; APOL2; LRP6; PPY; AGXT; PTK6; LPL

Interacting Protein

PICK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PICK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PICK1.
ASIC1; SLC6A3; SLC6A2; ASIC2; PRLHR; ATXN7; PRKCG; SLC6A4; AKT1

PICK1 Related Articles

Ramos, C; Chardonnet, S; et al. Native Presynaptic Metabotropic Glutamate Receptor 4 (mGluR4) Interacts with Exocytosis Proteins in Rat Cerebellum. JOURNAL OF BIOLOGICAL CHEMISTRY 287:20176-20186(2012).
Selak, S; Paternain, AV; et al. A Role for SNAP25 in Internalization of Kainate Receptors and Synaptic Plasticity. NEURON 63:357-371(2009).