Recombinant Human PICK1 Protein (1-200 aa), GST-tagged

• Cat.No.: PICK1-1216H
• Product Overview: Recombinant Human PICK1 Protein (1-200 aa) is produced by E. coli expression system. This protein is fused with a GST tag at the N-terminal. Research Area: Signal Transduction. Protein Description: Partial.

Specification

• Description: Probable adapter protein that bind to and organize the subcellular localization of a variety of mbrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel. Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competetive with nucleation promoting factors and is linked to neuronal morphology regulation and AMPA receptor (AMPAR) endocytosis. Via interaction with the Arp2/3 complex involved in regulation of synaptic plasicity of excitatory synapses and required for spine shrinkage during long-term depression (LTD). Involved in regulation of astrocyte morphology, antagonistic to Arp2/3 complex activator WASL/N-WASP function.
• Source: E. coli
• Species: Human
• Tag: GST
• Form: Tris-based buffer,50% glycerol
• Molecular Mass: 48.9 kDa
• Protein length: 1-200 aa
• AA Sequence: MFADLDYDIEEDKLGIPTVPGKVTL QKDAQNLIGISIGGGAQYCPCLYIV QVFDNTPAALDGTVAAGDEITGVNG RSIKGKTKVEVAKMIQEVKGEVTIH YNKLQADPKQGMSLDIVLKKVKHRL VENMSSGTADALGLSRAILCNDGLV KRLEELERTAELYKGMTEHTKNLLR AFYELSQTHRAFGDVFSVIGVREPQ
• Purity: > 90% as determined by SDS-PAGE.
• Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week.
• Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade.
• Concentration: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Gene Information

• Gene Name: PICK1 protein interacting with PRKCA 1 [ Homo sapiens ]
• Official Symbol: PICK1
• Synonyms: PICK1; dJ1039K5; MGC15204; PICK; PRKCABP
• Gene ID: 9463
• mRNA Refseq: NM_001039583
• Protein Refseq: NP_001034672
• MIM: 605926
• UniProt ID: Q9NRD5