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POLD1

Official Full Name

polymerase (DNA directed), delta 1, catalytic subunit 125kDa
Overview

This gene encodes the 125-kDa catalytic subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase;and 3 to 5 exonuclease activity and plays a critical role in DNA replication and repair. Alternatively spliced;transcript variants have been observed for this gene, and a pseudogene of this gene is located on the long arm of;chromosome 6.
Synonyms

POLD1; polymerase (DNA directed), delta 1, catalytic subunit 125kDa; POLD, polymerase (DNA directed), delta 1, catalytic subunit (125kD); DNA polymerase delta catalytic subunit; CDC2; CDC2 homolog (S. cerevisiae); CDC2 homolog; DNA polymerase subunit del;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Rat
Zebrafish

Source

E.coli
HEK293
Mammalian Cell

Tag

His
His (Fc)
Avi
His|GST
N/A
N
GST

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	POLD1-28360TH	Recombinant Human POLD1, His-tagged	E.coli	His		Inquiry
Human	POLD1-8025H	Recombinant Human POLD1 protein, His & GST-tagged	E.coli	His/GST	Met41~Phe254 (Accession # P28340)	Inquiry
Human	POLD1-3053HCL	Recombinant Human POLD1 293 Cell Lysate	HEK293	N/A		Inquiry
Human	POLD1-4951H	Recombinant Human POLD1 Protein (Met41-Phe254), N-GST tagged	E.coli	N-GST	Met41-Phe254	Inquiry
Mouse	POLD1-13068M	Recombinant Mouse POLD1 Protein	Mammalian Cell	His		Inquiry
Mouse	Pold1-1958M	Recombinant Mouse Pold1 Protein, His-tagged	E.coli	N-His	Ser29-Gly260	Inquiry
Mouse	POLD1-6904M	Recombinant Mouse POLD1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	POLD1-6904M-B	Recombinant Mouse POLD1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rat	POLD1-4562R	Recombinant Rat POLD1 Protein	Mammalian Cell	His		Inquiry
Rat	POLD1-4222R-B	Recombinant Rat POLD1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rat	POLD1-4222R	Recombinant Rat POLD1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Zebrafish	POLD1-3654Z	Recombinant Zebrafish POLD1	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein

POLD1 involved in several pathways and played different roles in them. We selected most pathways POLD1 participated on our site, such as Purine metabolism, Pyrimidine metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with POLD1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Purine metabolism	PDE7A;ENTPD1;PDE11A;PAPSS2B;ENPP3;POLR2K;POLR3D;URAD;POLR3B
Pyrimidine metabolism	PNP5A;ITPA;POLR2EB;PNP;NME6;POLR1C;NT5C3A;POLR3B;TXNRD2
Metabolic pathways	DGKAA;DNMT1;PYGB;NT5C2A;SMPD5;FUT3;ACSL1A;NDUFA4L;B3GNT5B
DNA replication	PCNA;POLE3;RPA4;POLE;SSBP1;GINS4;POLE4;GMNN;FEN1
Base excision repair	PARP3;MPG;POLD4;PNKP;HMGB1A;NTHL1;POLB;APEX1;POLD3
Nucleotide excision repair	RFC5;CCNH;NFRKB;ERCC8;CHD1L;USP45;RPA1;RPA2;ACTR5
Mismatch repair	MSH3;PMS2;MSH6;POLD2;MSH2;RFC4;RFC3;LIG1;POLD1
Homologous recombination	TOP3A;MUS81;RAD51L3;POLD4;EME1;NBN;FUZ;SSBP1;RAD51C
HTLV-I infection	MRAS;SMAD4;LTA;TRP53;ATM;GPS2;WNT9B;TP53;HLA-B

POLD1 has several biochemical functions, for example, 3-5-exodeoxyribonuclease activity, 4 iron, 4 sulfur cluster binding, DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by POLD1 itself. We selected most functions POLD1 had, and list some proteins which have the same functions with POLD1. You can find most of the proteins on our site.

Function	Related Protein
3-5-exodeoxyribonuclease activity	POLD1;TREX2;TREX1
4 iron, 4 sulfur cluster binding	BRIP1;EXO5;ISCA1;NFU1;TYW1;RSAD1;ETFDH;ACO1;POLD1
DNA binding	HIST2H2AA2;ZNF581;VDRA;FOXI3A;SS18L1;PRKRIR;MTERFD1;SSRP1;HOXC6B
DNA-directed DNA polymerase activity	POLG;POLD4;CCDC111;POLA2;POLE4;POLD1;PAPD7;POLH;POLL
chromatin binding	FOXO1;WAC;MTA3;TRIM24;MSGN1;SMARCA2;PELP1;KDM6B;TSHZ3
damaged DNA binding	TP53;PCNA;NEIL1;RAD23AA;XRCC6;XPC;POLB;TDG;FEN1
metal ion binding	TKTL2;BAK1;HPDA;POLR2A;UNK;S100A10A;NCALDB;ZFP541;ITGB7
nucleotide binding	RHOAA;NTRK2B;CIRBP;ORC4L;DPYDB;HUG;SFPQ;Abca2;PTK2BB
protein binding	PRLR;SSSCA1;TNP1;TMEM93;RALBP1;TTN;GAN;PDZD11;METTL15

POLD1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with POLD1 here. Most of them are supplied by our site. Hope this information will be useful for your research of POLD1.

POLD4; POLD2