prkcq
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  • Official Full Name
  • protein kinase C, theta
  • Background
  • Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role. The protein encoded by this gene is one of the PKC family members. It is a calcium-independent and phospholipid-dependent protein kinase. This kinase is important for T-cell activation. It is required for the activation of the transcription factors NF-kappaB and AP-1, and may link the T cell receptor (TCR) signaling complex to the activation of the transcription factors.
  • Synonyms
  • PRKCQ; protein kinase C, theta; protein kinase C theta type; PRKCT; nPKC-theta; MGC126514; MGC141919
Cat.#:PRKCQ-2704HTag:His/GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PRKCQ protein, His & GST-tagged
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Cat.#:PRKCQ-30178THTag:
Source (Host):Species:Human
Product nameRecombinant Human PRKCQ
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Cat.#:PRKCQ-3607RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey PRKCQ Protein, His-tagged
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Cat.#:PRKCQ-5522ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish PRKCQ
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Cat.#:PRKCQ-408HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Protein Kinase C, Theta, GST-tagged, Active
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Cat.#:PRKCQ-916HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Protein Kinase C, Theta, His-tagged
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Cat.#:PRKCQ-1416HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PRKCQ cell lysate
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Involved Pathway

PRKCQ involved in several pathways and played different roles in them. We selected most pathways PRKCQ participated on our site, such as NF-kappa B signaling pathway, Vascular smooth muscle contraction, Tight junction, which may be useful for your reference. Also, other proteins which involved in the same pathway with PRKCQ were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
NF-kappa B signaling pathway
LTBR; LTB; TICAM2; TNF; MAP3K7; NFKBIA; RELA; CXCL12; IRAK1; CCL19
Vascular smooth muscle contraction
CALML5; PPP1R14AB; PLA2G2D; CALM2; PRKACBA; BRAF; PRKCD; AVPR1A; GNA13A; GNA11A
Tight junction
PRKCBA; CLDN8; MYH4; EPB41; PRKCHA; CLDN5A; EPB41L1; ACTB2; CLDNG; PRKCZ
T cell receptor signaling pathway
MAP2K2; PDPK1; MAPK13; IFNG; MAP3K7; PAK3; PPP3R2; MAPK3; IL5; PAK2
Inflammatory mediator regulation of TRP channels
IL1RAP; CAMK2A; PIK3CG; PLCB4; CYP2C54; ASIC3; MAP2K3; PIK3CD; TRPA1; PRKCD
Adipocytokine signaling pathway
SLC2A1; ACACB; ADIPOR2; G6PC3; PPARGC1A; ADIPOR1; CHUK; PCK1; PRKAB1; RXRG
Insulin resistance
G6PC; PRKCQ; SREBF1; PPP1CAB; PYGM; PRKAA2; PPP1R3D; PIK3R3B; SLC27A2; FOXO1A
Measles
CLEC4M; SLAMF1; IFNA5; PIK3R3; PRKCQ; EIF2AK4; TRAF6; CCNE2; CD28; CBLB

Protein Function

PRKCQ has several biochemical functions, for example, ATP binding, metal ion binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PRKCQ itself. We selected most functions PRKCQ had, and list some proteins which have the same functions with PRKCQ. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein CLK4; KHK; SMYHC2; ABCC3; KIF11; RIPK1L; HSPA7; BUB1B; KIT; RFK
Function metal ion binding
Related Protein LMTK3; PRICKLE2B; CNDP2; DSG1A; HENMT1; ZFYVE27; CYP2AA9; CALUB; USP2; TKTL1
Function protein binding
Related Protein TRP63; TNNI3K; GPR37L1; HIST1H1E; NADK; PI4KA; TLE3A; KRT20; LMAN1; ANXA6
Function protein kinase C activity
Related Protein PRKCHB; PRKCBB; PRKCB; PRKCI; PRKCD; PRKCH; PRKCQ; PRKD3; PRKCA; PRKCG
Function protein serine/threonine kinase activity
Related Protein ROCK2B; SIK2A; MAPK14B; SMOK3B; CSNK1A1; MAP4K6; IKBKB; NEK10; PIM2; KALRN
Function ubiquitin-protein transferase activity
Related Protein PDZRN3; FBXO25; NHLRC1; UBE2K; UBE2T; ITCH; UBE2B; DTX3L; FBXO2; RNF25

Interacting Protein

PRKCQ has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PRKCQ here. Most of them are supplied by our site. Hope this information will be useful for your research of PRKCQ.
FYN; MAP4K3; N/A; GLRX3; PRKCZ

PRKCQ Related Articles

Ovsyannikova, IG; Kennedy, RB; et al. Genome-wide association study of antibody response to smallpox vaccine. VACCINE 30:4182-4189(2012).
Zheng, YB; Zhang, WS; et al. Improved insulin sensitivity by calorie restriction is associated with reduction of ERK and p70(S6K) activities in the liver of obese Zucker rats. JOURNAL OF ENDOCRINOLOGY 203:337-347(2009).