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RBX1

  • Official Full Name

    ring-box 1, E3 ubiquitin protein ligase

  • Overview

    This locus encodes a RING finger-like domain-containing protein. The encoded protein interacts with cullin proteins and likely plays a role in ubiquitination processes necessary for cell cycle progression. This protein may also affect protein turnover. Related pseudogenes exist on chromosomes 2 and 5.[provided by RefSeq, Sep 2010]
  • Synonyms

    RBX1; ring-box 1, E3 ubiquitin protein ligase; ROC1; RNF75; BA554C12.1; E3 ubiquitin-protein ligase RBX1; ZYP protein; RING box protein 1; RING-box protein 1; RING finger protein 75; regulator of cullins 1;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Cynomolgus Monkey
  • Human
  • Mouse
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Mammalian cells
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
  • T7
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human RBX1-2902H Recombinant Human RBX1, T7-tagged E.coli T7
Human RBX1-31333TH Recombinant Human RBX1 E.coli N/A
Human RBX1-2389H Recombinant Human Ring-box 1, His-tagged E.coli His
Human RBX1-2227H Recombinant Human RBX1, His-tagged E.coli His 1-108aa
Human RBX1-2450HCL Recombinant Human RBX1 293 Cell Lysate HEK293 N/A
Human RBX1-969H Recombinant Human RBX1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human RBX1-3416H Recombinant Human RBX1 protein, GST-tagged E.coli GST 1-108aa
Human RBX1-1867H Recombinant Human RBX1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human RBX1-1980HFL Recombinant Full Length Human RBX1 Protein, C-Flag-tagged Mammalian cells Flag
Human RBX1-1867H-B Recombinant Human RBX1 Protein Pre-coupled Magnetic Beads HEK293
Mouse RBX1-14024M Recombinant Mouse RBX1 Protein Mammalian Cell His
Mouse RBX1-7492M Recombinant Mouse RBX1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse RBX1-7492M-B Recombinant Mouse RBX1 Protein Pre-coupled Magnetic Beads HEK293
Mouse Rbx1-5431M Recombinant Mouse Rbx1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Cynomolgus Monkey RBX1-850C Recombinant Cynomolgus RBX1 Protein, His-tagged Mammalian Cell His
Cynomolgus Monkey RBX1-593C Recombinant Cynomolgus Monkey RBX1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Cynomolgus Monkey RBX1-593C-B Recombinant Cynomolgus Monkey RBX1 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish RBX1-5404Z Recombinant Zebrafish RBX1 Mammalian Cell His
Chicken RBX1-4253C Recombinant Chicken RBX1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

RBX1 involved in several pathways and played different roles in them. We selected most pathways RBX1 participated on our site, such as Nucleotide excision repair, HIF- signaling pathway, Cell cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with RBX1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Nucleotide excision repairGTF2H4;COPS8;RFC5;INO80;XPC;POLD2;POLE2;POLD4;BIVM-ERCC5
HIF- signaling pathwayVEGFA;PIK3CD;LDHA;HK3;TEK;RPS6KB2;PIK3CA;Trf;TFRC
Cell cycleSMC2;DYNC1H1;UBE2V2;PMF1;TP53;CDCA5;SPO11;CCNB2;TGFB1A
Oocyte meiosisYWHABA;CALM3;PPP2R1B;AURKA;STAG3;CDC16;PPP3R2;CPEB2;CAMK2B1
Ubiquitin mediated proteolysisUBE4B;BIRC2;UBE2N;UBE2D4;BIRC3;CBL;CUL2;UBE2L3A;UBE2G1B
Protein processing in endoplasmic reticulumNFE2L2A;NFE2L2;HSP90AA1;DNAJB2;DNAJC3A;TUSC3;ERP29;CAPN2B;SEL1L
Wnt signaling pathwayRHOAA;FZD6;WNT10B;ROCK2A;DVL1B;SOST;DAAM1;MAPK8B;RBX1
TGF-beta signaling pathwaySMAD5;NOG2;SMURF2;SPAW;TGFB1;RBX1;NDR1;SMAD1;GDF5
Circadian rhythmFBXW11;RORB;PER2;RORA;CRY1;PRKAA1;PRKAG1;NPAS2;BTRC
Pathways in cancerWNT9A;RALGDS;RXRB;LAMC2;RAD51;PRKACB;WNT3;BIRC3;FOXO1
Renal cell carcinomaTGFA;TGFB3;CDC42;TCEB2;PIK3CA;MAPK3;ARAF;BRAF;GAB1

RBX1 has several biochemical functions, for example, NEDD8 transferase activity, cullin family protein binding, ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by RBX1 itself. We selected most functions RBX1 had, and list some proteins which have the same functions with RBX1. You can find most of the proteins on our site.

Function Related Protein
NEDD8 transferase activityUBE2F;RBX1;UBE2M;RNF7
cullin family protein bindingDCUN1D5;TCHP;RBX1;DCUN1D2A;DCUN1D4;DCUN1D1;CCDC22;RNF7;KCTD17
ligase activityUBE2KB;RNF180;TRIM38;UBE2NB;TRIM23;TRIML1;RNF144B;UBE2L3B;HECTD3
protein bindingBBS9;DDX42;CIR1;HIST1H2AH;HYI;ZBTB43;RTN4R;ROBO1;HNRNPU
protein complex bindingRAP1B;PCSK2;CDH2;TXN2;RRAS;HSPD1;WASF2;SKAP1;CAV3
ubiquitin protein ligase activityRNF19B;RNF111;STUB1;UBE2J1;MGRN1;MARCH1;RBX1;TOPORS;RAG1
ubiquitin protein ligase bindingSMAD3;PRKAR2A;PER1;GLMN;POLR2A;BID;KCNH2;GABARAPL2;TRIB1
contributes_to ubiquitin-protein transferase activityUBE2C;ANAPC11;KLHL14;KLHL32;KLHL31;BCOR;BACH2;KLHL13;KLHL29
ubiquitin-ubiquitin ligase activityRBX1;STUB1;UBOX5;PPIL2;UBE2K;PRPF19;UBE4B;ANAPC11;AMFR
zinc ion bindingGRIN2A;LHX5;ADAM30;MGRN1;RANBP2;TNFAIP3;WBP4;NPLOC4;RNF13

RBX1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RBX1 here. Most of them are supplied by our site. Hope this information will be useful for your research of RBX1.

CUL1; CUL4B

  • Q&As
  • Reviews

Q&As (7)

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How does RBX1 contribute to proteasome-mediated degradation? 12/28/2022

It facilitates the attachment of ubiquitin, directing proteins to the proteasome for breakdown.

What potential therapeutic applications arise from targeting RBX1 in diseases? 07/26/2022

Targeting RBX1 offers potential for treating diseases with dysregulated protein turnover, including cancer.

What is the impact of altered RBX1 activity on cancer development? 02/25/2022

Altered RBX1 activity is associated with cancer progression, influencing cell proliferation and survival.

What role does RBX1 play in cell cycle regulation? 12/22/2020

RBX1 plays a role in cell cycle control by regulating the degradation of key cycle-related proteins.

How do genetic variations in RBX1 affect cellular processes? 11/18/2019

Genetic mutations in RBX1 can lead to disruptions in protein turnover, affecting various cellular functions.

What is the primary role of RBX1 in protein ubiquitination? 05/13/2018

RBX1, a RING-finger protein, is crucial for tagging proteins with ubiquitin, marking them for degradation.

How does RBX1 interact with other components of the ubiquitin-proteasome system? 10/08/2017

RBX1 works with other ubiquitin-proteasome system components, orchestrating protein degradation.

Customer Reviews (3)

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Reviews
03/01/2020

    Efficiency and precision, vital for research quality.

    11/02/2019

      Critical for decision-making, accelerates research productivity.

      04/04/2017

        Enhances research credibility, a cornerstone of our research.

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