rps6ka4
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  • Official Full Name
  • ribosomal protein S6 kinase, 90kDa, polypeptide 4
  • Background
  • This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including CREB1 and c-fos. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]
  • Synonyms
  • RPS6KA4; ribosomal protein S6 kinase, 90kDa, polypeptide 4; MSK2; RSK-B; ribosomal protein S6 kinase alpha-4; RSKB; S6K-alpha-4; ribosomal protein kinase B; ribosomal protein S6 kinase alpha 4; 90 kDa ribosomal protein S6 kinase 4; mitogen- and stress-activated protein kinase 2; nuclear mitogen- and stress-activated protein kinase 2;
Cat.#:RPS6KA4-2434HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RPS6KA4, His-tagged
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Cat.#:RPS6KA4-29913THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RPS6KA4, His-tagged
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Cat.#:RPS6KA4-14496MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse RPS6KA4 Protein
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Cat.#:RPS6KA4-4029RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey RPS6KA4 Protein, His-tagged
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Cat.#:RPS6KA4-6718ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish RPS6KA4
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Cat.#:Rps6ka4-1062MTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Mouse
Product nameRecombinant Mouse Ribosomal Protein S6 Kinase, Polypeptide 4, GST-tagged
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Cat.#:RPS6KA4-2160HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human RPS6KA4 293 Cell Lysate
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Involved Pathway

RPS6KA4 involved in several pathways and played different roles in them. We selected most pathways RPS6KA4 participated on our site, such as MAPK signaling pathway, TNF signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with RPS6KA4 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
GRB2; LAMTOR3; GADD45AA; MAPK8IP3; CACNB2; FLNB; HSP70L; NLK2; MAP3K7; FGFR1
TNF signaling pathway
CASP10; MAPK13; MAP3K7IP3; MAP3K7; CX3CL1; ATF4; CCL2; TRAF5; CFLAR; NFKB1

Protein Function

RPS6KA4 has several biochemical functions, for example, ATP binding, histone kinase activity (H3-S10 specific), magnesium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RPS6KA4 itself. We selected most functions RPS6KA4 had, and list some proteins which have the same functions with RPS6KA4. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein UBA3; PARS2; Ckmm; MYH1E; ITPK1; NADKD1; TRNT1; PAPOLG; KCNJ11; EPHA2A
Function histone kinase activity (H3-S10 specific)
Related Protein RPS6KA5; RPS6KA4; VRK1
Function magnesium ion binding
Related Protein SPHK1; PRPS1; STK4; NT5C3L; ATP8B5; EPHX2; HPRT1L; RNASEH1; PPM1A; TSSK4
Function mitogen-activated protein kinase p38 binding
Related Protein TAB1; NFATC1; PRMT1; SPAG9; RPS6KA4
Function protein binding
Related Protein F11R; LY6H; NUDT16L1; ZRANB1; HNF4A; DVL2; RAP1GAP; INMT; SMG9; IRX1
Function protein serine/threonine kinase activity
Related Protein SLKA; AKT3A; CSNK2A2; ATM; BMPR1BB; STK31; CSNK1G2B; TSSK1; STK35; SMOK3B
Function ribosomal protein S6 kinase activity
Related Protein RPS6KA4; RPS6KB1; RPS6KB2; RPS6KA3A; RPS6KA3B; RPS6KA1; RPS6KA6; RPS6KA3; ALPK2; RPS6KA2

Interacting Protein

RPS6KA4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RPS6KA4 here. Most of them are supplied by our site. Hope this information will be useful for your research of RPS6KA4.
MAPK14; MAPK3; pi3p; linkable sunitinib analogue; purvalanol b; midostaurin; SNW1; CDC37; CDC5L