ralbp1
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  • Official Full Name
  • ralA binding protein 1
  • Background
  • RALBP1 plays a role in receptor-mediated endocytosis and is a downstream effector of the small GTP-binding protein RAL (see RALA; MIM 179550). Small G proteins, such as RAL, have GDP-bound inactive and GTP-bound active forms, which shift from the inactive to the active state through the action of RALGDS (MIM 601619), which in turn is activated by RAS (see HRAS; MIM 190020) (summary by Feig, 2003 [PubMed 12888294]).[supplied by OMIM, Nov 2010]
  • Synonyms
  • RALBP1; ralA binding protein 1; RIP1; RLIP1; RLIP76; ralA-binding protein 1; DNP-SG ATPase; ral-interacting protein 1; 76 kDa Ral-interacting protein; dinitrophenyl S-glutathione ATPase;
Cat.#:RALBP1-706HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RALBP1 Protein, His-tagged
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Cat.#:Ralbp1-708MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Ralbp1 Protein, His-tagged
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Cat.#:Ralbp1-710RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Ralbp1 Protein, His-tagged
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Cat.#:RALBP1-2167HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RALBP1, GST-tagged
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Cat.#:RALBP1-13896MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse RALBP1 Protein
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Cat.#:RALBP1-4917RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat RALBP1 Protein
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Cat.#:RALBP1-3216CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken RALBP1
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Cat.#:RALBP1-11811ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish RALBP1
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Cat.#:RALBP1-2542HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human RALBP1 293 Cell Lysate
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Involved Pathway

RALBP1 involved in several pathways and played different roles in them. We selected most pathways RALBP1 participated on our site, such as EGFR1 Signaling Pathway, Pancreatic cancer, Pathways in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with RALBP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
EGFR1 Signaling Pathway
GRB10; EPPK1; ZPR1; CRKL; STXBP1A; USP6NL; KRT7; DNM1; PTK6; DOK2
Pancreatic cancer
BCL2L1; SMAD3; STAT3; TGFA; TGFB1; CDC42; NFKB1; MAP2K1; ARAF; RALB
Pathways in cancer
FGF3; RXRA; EGLN2; SKP2; FGF8; FZD3; RXRG; WNT2; RUNX1T1; MITF
RalA downstream regulated genes
EXOC8; RALBP1
Ras signaling pathway
MAP2K2; PIK3CD; RASAL2; GNG12; RASSF1; FLT1; RALB; GRIN2B; GRIN2A; FGFR4
Regulation of CDC42 activity
RALBP1; BCAR3; ARHGEF25; ARHGAP1; ITSN2; MCF2L; DNMBP; DOCK6; ARHGAP17; DOCK10
Regulation of RAC1 activity
ARHGAP9; SPATA13; RALBP1; ARHGAP17; ABR; PREX2; EPS8; RAP1GDS1; CHN2; DOCK6
Rho GTPase cycle
ARHGAP20; ARHGAP15; ARHGAP12; ARHGAP29; ECT2; FAM13B1; ARHGAP25; ARHGAP22; ARHGAP10; STARD13

Protein Function

RALBP1 has several biochemical functions, for example, ATPase activity, ATPase activity, coupled to movement of substances, GTPase activator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by RALBP1 itself. We selected most functions RALBP1 had, and list some proteins which have the same functions with RALBP1. You can find most of the proteins on our site.
Function
Related Protein
Function ATPase activity
Related Protein ABCE1; RNF213; MLH3; ABCB4; DNAH5; CARNS1; VPS4B; MLH1; ABCB6; ABCF2
Function ATPase activity, coupled to movement of substances
Related Protein RALBP1
Function GTPase activator activity
Related Protein TBC1D9; TBC1D26; MURC; ASAP1A; ARHGAP24; RP2; EVI5L; EVI5; ARHGAP11A; ARHGAP44
Function Rac GTPase binding
Related Protein DOCK4; SRGAP2A; SOD1; PKN1; RCC2; NOX1; SRGAP2; ARFIP2; CORO1C; PAK3
Function Ral GTPase binding
Related Protein MYO1C; PRKCH; RAB34; LSM2; EXOC5; EXOC4; FLNA; EXOC8; USP33; PIH1D2
Function protein binding
Related Protein EXOSC10; PDXP; HNRNPC; SCYL3; ARHGEF10; HNRNPH2; CCDC155; RYBP; TAGLN2; TRPV6
Function transmembrane transporter activity
Related Protein SV2A; RALBP1; ATP5H; SLC2A13B; SLC2A11L; ATP5E; SLC2A1A; SLCO1D1; ATP5C1; SLC22A16

Interacting Protein

RALBP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RALBP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of RALBP1.
CEP57; CCL20; TAX1BP1; AP2M1; TFPT; PPL

RALBP1 Related Articles

Chao, LJ; Lu, L; et al. Identification of a Human Protein-Derived HIV-1 Fusion Inhibitor Targeting the gp41 Fusion Core Structure. PLOS ONE 8:-(2013).
Drake, KJ; Singhal, J; et al. RALBP1/RLIP76 mediates multidrug resistance. INTERNATIONAL JOURNAL OF ONCOLOGY 30:139-144(2007).