Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at BIO-Europe Spring|March 18–20, 2024|Booth #34

SLIT2

  • Official Full Name

    slit homolog 2 (Drosophila)

  • Overview

    Thought to act as molecular guidance cue in cellular migration, and function appears to be mediated by interaction with roundabout homolog receptors. During neural development involved in axonal navigation at the ventral midline of the neural tube and projection of axons to different regions. SLIT1 and SLIT2 seem to be essential for midline guidance in the forebrain by acting as repulsive signal preventing inappropriate midline crossing by axons projecting from the olfactory bulb. In spinal chord development may play a role in guiding commissural axons once they reached the floor plate by modulating the response to netrin. In vitro, silences the attractive effect of NTN1 but not its growth-stimulatory effect and silencing requires the formation of a ROBO1-DCC complex. May be implicated in spinal chord midline post-crossing axon repulsion. In vitro, only commissural axons that crossed the midline responded to SLIT2. In the developing visual system appears to function as repellent for retinal ganglion axons by providing a repulsion that directs these axons along their appropriate paths prior to, and after passage through, the optic chiasm. In vitro, collapses and repels retinal ganglion cell growth cones. Seems to play a role in branching and arborization of CNS sensory axons, and in neuronal cell migration. In vitro, Slit homolog 2 protein N-product, but not Slit homolog 2 protein C-product, repels olfactory bulb (OB) but not dorsal root ganglia (DRG) axons, induces OB growth cones collapse and induces branching of DRG axons. Seems to be involved in regulating leukocyte migration.
  • Synonyms

    SLIT2; slit homolog 2 (Drosophila); SLIL3, slit (Drosophila) homolog 2; slit homolog 2 protein; Slit 2; SLIL3; Slit-2; FLJ14420;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • CHO
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Mammalian cells
  • C
  • His
  • Flag
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human SLIT2-402H Active Recombinant Human SLIT2 Protein HEK293 N/A
Human SLIT2-30441TH Recombinant Human SLIT2 N/A
Human SLIT2-965H Recombinant Human Slit Homolog 2 (Drosophila) HEK293 N/A
Human SLIT2-757H Recombinant Human SLIT2 protein, His-tagged E.coli His Val1160~Cys1333 (Accession # O94813)
Human SLIT2-758H Recombinant Human SLIT2 protein, His-tagged E.coli His Cys1416~Val1528 (Accession # O94813)
Human SLIT2-1683HCL Recombinant Human SLIT2 293 Cell Lysate HEK293 N/A
Human SLIT2-3960H Recombinant Human SLIT2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human SLIT2-2035H Recombinant Human SLIT2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human SLIT2-1147HFL Recombinant Full Length Human SLIT2 Protein, C-Flag-tagged Mammalian cells Flag
Human SLIT2-2703H Recombinant Human SLIT2 Protein, His-tagged E.coli N-His Asn664-Lys777
Human SLIT2-2035H-B Recombinant Human SLIT2 Protein Pre-coupled Magnetic Beads HEK293
Human SLIT2-3300H Recombinant Human SLIT2 Protein (Cys1416-Val1528), His tagged E.coli His Cys1416-Val1528
Human SLIT2-0720H Recombinant Human SLIT2 protein, His-tagged HEK293 His Leu271-Ser479
Human SLIT2-6696H Recombinant Human SLIT2 Protein (Leu271-Cys478), C-His tagged E.coli C-His Leu271-Cys478
Human SLIT2-6697H Recombinant Human SLIT2 Protein (Leu271-478Cys), N-His tagged Mammalian cells N-His Leu271-478Cys
Mouse Slit2-20M Active Recombinant Mouse Slit2, His-tagged CHO His
Mouse SLIT2-15563M Recombinant Mouse SLIT2 Protein Mammalian Cell His
Mouse Slit2-759M Recombinant Mouse Slit2 protein, His-tagged E.coli His Gln31~His197 (Accession # Q9R1B9)
Mouse Slit2-760M Recombinant Mouse Slit2 protein, His-tagged E.coli His Cys1408~Cys1519 (Accession # Q9R1B9)
Mouse SLIT2-8447M Recombinant Mouse SLIT2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Slit2-8446M-B Recombinant Mouse Slit2 Protein Pre-coupled Magnetic Beads HEK293
Mouse Slit2-18M Active Recombinant Mouse Slit2 Protein, His-tagged Mammalian cells His Thr1114-Ser1521
Mouse Slit2-5944M Recombinant Mouse Slit2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse SLIT2-8447M-B Recombinant Mouse SLIT2 Protein Pre-coupled Magnetic Beads HEK293
Mouse Slit2-8446M Recombinant Mouse Slit2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat Slit2-761R Recombinant Rat Slit2 protein, His-tagged E.coli His Asn209~Gly374
Zebrafish SLIT2-9255Z Recombinant Zebrafish SLIT2 Mammalian Cell His
Chicken SLIT2-4636C Recombinant Chicken SLIT2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • SLIT2 Related Articles
  • SLIT2 Related Research Area

SLIT2 involved in several pathways and played different roles in them. We selected most pathways SLIT2 participated on our site, such as Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with SLIT2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Axon guidanceRGS3;CLTA;EFNA3;FGF10B;SPTBN1;EFNA5;WDR83;SRGAP3;SPRED3

SLIT2 has several biochemical functions, for example, GTPase inhibitor activity, Roundabout binding, calcium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SLIT2 itself. We selected most functions SLIT2 had, and list some proteins which have the same functions with SLIT2. You can find most of the proteins on our site.

Function Related Protein
GTPase inhibitor activityPDE6D;GPS1;CPEB2;ARL2;SLIT2;GPS2;CDC42SE1;TNK2;RTKN
Roundabout bindingGM4980;SLIT1A;SLIT1B;UBE4A;SLIT1;SLIT3;TGFB1I1;SLIT2
calcium ion bindingC2CD4A;JAG2B;PRKCSH;NID2;PGS1;PLA2G12B;CAPNS1B;MYL12.2;ASPH
chemorepellent activitySEMA3D;SEMA3B;Sema3f;SEMA4E;SEMA6E;SEMA4A;APOA1;SEMA4C;SEMA3BL
heparan sulfate proteoglycan bindingGPC5A;SEMA5A;HRG;COMP;GPC1;PLA2G2D;ITGAM;FST;GPC6A
heparin bindingFGF7;CTGFB;AZU1;ECM2;CCL15;SELL;ADAMTS3;FGF12;LIPI
identical protein bindingPYCARD;SIAH1A;CAV1;GRIN3A;APLP1;DCTPP1;RABAC1;CDC42BPA;UHRF1
laminin-1 bindingUBE4A;DAG1;NTN4;LACRT;SLIT2;NID1;Shh
protein bindingPDZK1;DTX1;C10orf62;E2F4;CDC5L;TAF15;DDX47;C1QTNF9;SPCS1
protein homodimerization activityZFP365;KCNK3;E2F8;NTSR1;HEXB;TCF3;CD247;FASN;ERBB3
proteoglycan bindingCECR1;CTSS;FCN2;NID1;CTSL1;CTSB;THBS1;COL5A1;UBE4A

SLIT2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SLIT2 here. Most of them are supplied by our site. Hope this information will be useful for your research of SLIT2.

ETS1; BILF1; mgtA; yfiS; q8clc4_yerpe; q9wmx2-pro_0000037546; q9wmx2-pro_0000037548; MYC

Qi, CL; Lan, HM; et al. Slit2 promotes tumor growth and invasion in chemically induced skin carcinogenesis. LABORATORY INVESTIGATION 94:766-776(2014).
Pircher, A; Wellbrock, J; et al. New Antiangiogenic Strategies beyond Inhibition of Vascular Endothelial Growth Factor with Special Focus on Axon Guidance Molecules. ONCOLOGY 86:46-52(2014).
  • Q&As
  • Reviews

Q&As (0)

Ask a question

Customer Reviews (0)

Write a review

Ask a Question for All SLIT2 Products

Required fields are marked with *

My Review for All SLIT2 Products

Required fields are marked with *

logo

FOLLOW US

Terms and Conditions        Privacy Policy

Copyright © 2024 Creative BioMart. All Rights Reserved.

Contact Us

  • /

Stay Updated on the Latest Bioscience Trends