Recombinant Human Slit Homolog 2 (Drosophila)

• Cat.No.: SLIT2-965H
• Product Overview: Recombinant human Slit2-N produced in293 cellsis a 1088 amino acid glycoprotein corresponding to the N-terminal portion of the full length Slit2 precursor. Due to glycosylation Slit2-N migrates at an apparent molecular weight of approximately 110.0-116.0 kDa by SDS-PAGE analysis under reducing conditions.

Specification

• Species: Human
• Source: HEK293
• Tag: Non
• Description: Slit2 is a member of the Slit family that signals through the Roundabout (Robo) receptor as a repellent for axon guidance and neuronal migration, and can also act as a chemoattractant to vascular endothelial cells and a chemotaxis inhibitor for leukocytes. Slit2 is expressed primarily in the fetal lung, kidney, and adult spinal cord, and to a lesser extent in adult adrenal gland, thyroid and trachea. Slit2 is initially synthesized as a 1499 amino acid precursor, which is subsequently cleaved into N-terminal and C-terminal fragments, designated as Slit2-N and Slit2-C respectively. The neurodevelopment related activities, as measured by the ability to repel olfactory bulb axons and to induce branching in dorsal root ganglia axons, are contained only in the N-terminal fragment.
• Purity: 98 % (SDS-PAGE, HPLC).
• Endotoxin Level: < 0.1 ng per ug of Slit2-N.
• Stabilizer: None.
• Formulation: Lyophilized.
• Biological Activity: Data not available!
• Stability: The lyophilized protein is stable for a few weeks at room temperature, but best stored at -20℃. Reconstituted human Slit2-N should be stored in working aliquots at -20℃. Avoid repeated freeze-thaw cycles.
• Full Length: Full L.

Gene Information

• Gene Name: SLIT2 slit homolog 2 (Drosophila) [ Homo sapiens ]
• Synonyms: SLIT2;slit homolog 2 (Drosophila); SLIL3; Slit-2; FLJ14420; slit (Drosophila) homolog 2; Slit homolog 2 protein; Slit homolog 2 protein N-product; Slit homolog 2 protein C-product; FLJ14420; slit homolog 2
• Gene ID: 9353
• mRNA Refseq: NM_004787
• Protein Refseq: NP_004778
• MIM: 603746
• UniProt ID: O94813
• Chromosome Location: 4p15.2
• Pathway: Axon guidance
• Function: calcium ion binding; receptor binding