SNF8
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Official Full Name
SNF8, ESCRT-II complex subunit, homolog (S. cerevisiae)
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Overview
SNF8, VPS25 (MIM 610907), and VPS36 (MIM 610903) form ESCRT-II (endosomal sorting complex required for transport II), a complex involved in endocytosis of ubiquitinated membrane proteins. SNF8, VPS25, and VPS36 are also associated in a multiprotein complex with RNA polymerase II elongation factor (ELL; MIM 600284) (Slagsvold et al., 2005 -
Synonyms
SNF8; SNF8, ESCRT-II complex subunit, homolog (S. cerevisiae); vacuolar-sorting protein SNF8; Dot3; EAP30; VPS22; ELL associated protein of 30 kDa; ELL-associated protein of 30 kDa; ESCRT-II complex subunit VPS22; hVps22; SNF8 ESCRTII complex subunit homolog (S cerevisiae); SNF8_HUMAN; Vacuolar sorting protein SNF8; OTTHUMP00000218490; OTTHUMP00000218491; EAP30 subunit of ELL complex;
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- Myc
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- Involved Pathway
- Protein Function
- Interacting Protein
SNF8 involved in several pathways and played different roles in them. We selected most pathways SNF8 participated on our site, such as Endocytosis, Endosomal Sorting Complex Required For Transport (ESCRT), Membrane Trafficking, which may be useful for your reference. Also, other proteins which involved in the same pathway with SNF8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Endocytosis | SNX2;H2-Q10;BF1;CHMP2A;RAB5B;SH3GLB1A;RAB4A;LDLR;GRK4 |
| Endosomal Sorting Complex Required For Transport (ESCRT) | VPS37A;SNF8;CHMP4B;STAM2;CHMP4C |
| Membrane Trafficking | TERFA;GJA5;TPD52;GORASP1;NAPAA;MYO6;DTNBP1;EXOC6;SNX9A |
| Vesicle-mediated transport | HP;FTH1B;GJB7;AMBP;CLINT1;CLVS1;COPZ1;DTNBP1;AP1S3A |
SNF8 has several biochemical functions, for example, channel regulator activity, protein C-terminus binding, protein N-terminus binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SNF8 itself. We selected most functions SNF8 had, and list some proteins which have the same functions with SNF8. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| channel regulator activity | CACNG2;CACNG7A;CACNG7;CACNG4;CNIH3;CACNG2B;SLC9A3R2;SNF8;CACNG3 |
| protein C-terminus binding | DLG3;COIL;SLC9A3R2;PFKM;NCF2;VTA1;MED12;HSPB7;TAF13 |
| protein N-terminus binding | TP53;ERCC2;MNAT1;GTF2H2;STXBP1;SNCA;SNF8;KCNIP2;MYO7A |
| protein binding | PYDC1;UBXN1;SFRP4;APIP;USP46;MGARP;TBL1X;COG3;CRB3 |
| protein homodimerization activity | WWTR1;LGALS1;KIT;AGR2;SH3GLB1;SERPINF2;CARS;DMRT1;MAPK4 |
| transcription factor binding | KEAP1;DACT2;FHL2;NFATC2;CTBP1;THRA;CREG1;SRY;HDAC5 |
SNF8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SNF8 here. Most of them are supplied by our site. Hope this information will be useful for your research of SNF8.
VPS25; MCM2; ELL; GOLGA2
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