tada2a
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  • Official Full Name
  • transcriptional adaptor 2A
  • Background
  • Many DNA-binding transcriptional activator proteins enhance the initiation rate of RNA polymerase II-mediated gene transcription by interacting functionally with the general transcription machinery bound at the basal promoter. Adaptor proteins are usually required for this activation, possibly to acetylate and destabilize nucleosomes, thereby relieving chromatin constraints at the promoter. The protein encoded by this gene is a transcriptional activator adaptor and has been found to be part of the PCAF histone acetylase complex. Several alternatively spliced transcript variants encoding different isoforms of this gene have been described, but the full-length nature of some of these variants has not been determined.
  • Synonyms
  • ADA2; ADA2A; KL04P; hADA2; TADA2L; FLJ12705; transcriptional adapter 2-alpha; ADA2-like protein; OTTHUMP00000164062; OTTHUMP00000164063; transcriptional adaptor 2 alpha; TADA2A; transcriptional adaptor 2A
Cat.#:TADA2A-126HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TADA2A Protein, His-tagged
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Cat.#:TADA2A-16381MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse TADA2A Protein
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Cat.#:TADA2A-5910RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat TADA2A Protein
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Cat.#:TADA2A-2035CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken TADA2A
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Cat.#:TADA2A-4603ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish TADA2A
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Cat.#:TADA2A-1280HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human TADA2A 293 Cell Lysate
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Cat.#:TADA2A-1281HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human TADA2A 293 Cell Lysate
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Involved Pathway

TADA2A involved in several pathways and played different roles in them. We selected most pathways TADA2A participated on our site, such as Chromatin modifying enzymes, Chromatin organization, HATs acetylate histones, which may be useful for your reference. Also, other proteins which involved in the same pathway with TADA2A were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Chromatin modifying enzymes
MSL2B; SMARCD1; MSL1; PHF8; PBRM1; C20orf20; MORF4L1; KAT6A; MSL1A; PRMT6
Chromatin organization
DPY30; SAP30; WDR77; MORF4L1; KDM6B; TADA2B; PHF21A; RUVBL2; ATXN7L3; ZZZ3
HATs acetylate histones
ING5B; USP22; TADA2B; ENY2; MORF4L1; ACTL6A; MEAF6; SAP130; C3orf75; RUVBL2

Protein Function

TADA2A has several biochemical functions, for example, DNA binding, chromatin binding, contributes_to histone acetyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TADA2A itself. We selected most functions TADA2A had, and list some proteins which have the same functions with TADA2A. You can find most of the proteins on our site.
Function
Related Protein
Function DNA binding
Related Protein HIST1H2BI; PML; PRDM4; SRY; ZFP710; MLLT1; SSBP3A; MBD3; ZBTB1; MND1
Function chromatin binding
Related Protein SAFB; PHF21B; ING2; ZGLP1; SIRT6; BAHCC1; MAZ; CRX; RDBP; CIC
Function contributes_to histone acetyltransferase activity
Related Protein TADA2A; SAP130; KAT2A; TAF9; TADA3; TADA1; TAF5L; ELP4; ING3; TEX30
Function protein binding
Related Protein CTR9; AGPAT1; SNRNP25; AGR3; GAGE2D; MT1A; CDK20; BTN3A1; NKX3; DNASE1
Function transcription coactivator activity
Related Protein ZSCAN1; AIP; NR1I2; TCF3; PIAS2; MED13; PRPF6; JUNBB; SUB1; TFAP2B
Function transcription cofactor activity
Related Protein LDB2A; SUPT20H; RFXANK; ZNF671; MSX2; NSD1; MED17; FAM48A; ZNF865; KAT2B
Function transcription factor activity, sequence-specific DNA binding
Related Protein FOXH1; RFX1A; ZFP382; ZNF691; NFE2L1B; ZFP82; NEUROD1; SP1; LBX1; ESRRGB
Function zinc ion binding
Related Protein USP22; USP33; CXXC4; NR5A2; ZNRF2A; USP49; LONRF3; CPA2; NPSN; XRN2

Interacting Protein

TADA2A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TADA2A here. Most of them are supplied by our site. Hope this information will be useful for your research of TADA2A.
PRPF31; EIF4E2; MTX2; FARS2; MFAP1; MAGOH; SF3A3

TADA2A Related Articles

Martin, M; Geudens, I; et al. PP2A regulatory subunit B alpha controls endothelial contractility and vessel lumen integrity via regulation of HDAC7. EMBO JOURNAL 32:2491-2503(2013).
Zhang, J; Wang, S; et al. Herpes simplex virus 1 DNA polymerase processivity factor UL42 inhibits TNF-alpha-induced NF-kappa B activation by interacting with p65/RelA and p50/NF-kappa B1. MEDICAL MICROBIOLOGY AND IMMUNOLOGY 202:313-325(2013).