tln1
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  • Official Full Name
  • talin 1
  • Background
  • Talin, a multifunctional constituent of cell-substratum attachment sites, is a high molecular weight protein (225-235 kDa) found in variety of tissues and cell types. It is localized at a subset of adherens junctions, specialized cell-cell and cell-matrix associations that are characterized by the presence of filamentous actin at the cytoplasmic face of the junctional complex. In cultured cells, talin is absent from cell-cell junctions and found predominantly at adhesion plaques and in fibrillar streaks underlying cell surface fibronectin. Talin interacts with at least two other proteins that are localized at adhesion plaques, vinculin and integrin. Talin and vinculin have been shown to interact with each other and both have been proposed to be involved in generating the transmembrane connection, between the extracellular matrix and the cytoskeleton, that occurs at adhesion plaques. At physiological ionic strength, talin is an elongate, flexible, monomeric protein with the ability to self-associate into dimers at higher protein concentrations. Talin 2 is related to talin 1. This protein has a different pattern of expression compared to talin 1 but, like talin 1, is thought to associate with unique transmembrane receptors to form novel linkages between extracellular matrices and the actin cytoskeleton.
  • Synonyms
  • TLN1; talin 1; talin-1; Tln; MGC116305; Tln1
Cat.#:TLN1-1737HTag:His
Source (Host):YeastSpecies:Human
Product nameRecombinant Human TLN1 Protein (92-399 aa), His-tagged
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Cat.#:TLN1-31442THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TLN1, His-tagged
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Cat.#:TLN1-3256HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TLN1, His-tagged
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Cat.#:TLN1-353HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TLN1 Protein, His-tagged
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Cat.#:TLN1-354HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TLN1 Protein, His-tagged
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Cat.#:TLN1-16819MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse TLN1 Protein
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Cat.#:Tln1-355MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Tln1 Protein, His-tagged
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Cat.#:Tln1-356RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Tln1 Protein, His-tagged
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Cat.#:TLN1-6092CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken TLN1
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Cat.#:TLN1-1950ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish TLN1
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Cat.#:TLN1-890TTag:
Source (Host):Turkey Smooth muscleSpecies:Turkey
Product nameNative Turkey TLN1 Protein
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Involved Pathway

TLN1 involved in several pathways and played different roles in them. We selected most pathways TLN1 participated on our site, such as Rap signaling pathway, Focal adhesion, Platelet activation, which may be useful for your reference. Also, other proteins which involved in the same pathway with TLN1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Rap signaling pathway
RAC2; INSR; FGF16; Adcy4; PRKCG; KRAS; FGF17; PDGFC; GNAO1; PIK3CB
Focal adhesion
FYN; COL27A1B; THBS3A; STYK1; PPP1CC; RAF1; COL6A1; MAP2K1; RAC3B; RAC1B
Platelet activation
MYLK4; GUCY1B3; PLCG2; TLN1; PIK3R2; FGB; PLA2G4A; MAPK13; P2RY1; PTGIR
HTLV-I infection
DVL3; ATF4; TRP53; WNT2B; PDGFB; TBPL2; CANX; ANAPC11; MAPK8; HLA-DMB

Protein Function

TLN1 has several biochemical functions, for example, LIM domain binding, actin filament binding, integrin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TLN1 itself. We selected most functions TLN1 had, and list some proteins which have the same functions with TLN1. You can find most of the proteins on our site.
Function
Related Protein
Function LIM domain binding
Related Protein RIPK2; LDB1; LDB2; LDB1B; LDB2B; LDB2A; TLN1; LDB1A; RPH3AL; CSRP2BP
Function actin filament binding
Related Protein AJUBA; ACTN2; SHROOM1; GAS7; SLC6A4; ANTXR1; CORO1B; MYO1E; LASP1; CORO1C
Function integrin binding
Related Protein SFRP2; COL5A1; S1PR2; WISP1; ACTN2; EGFL6; ITGA5; CD226; COL3A1; ICAM5
Function protein binding
Related Protein TRAPPC6B; DUSP19; TTC17; KIFAP3; PHIP; APBB3; CCDC148; SEMA6A; FMR1; PSG5
Function structural constituent of cytoskeleton
Related Protein EPB41L3; TUBGCP3; TUBA4L; TUBA4A; MSN; ACTL6B; KRT20; GFAP; ARPC1B; TUBAL3
Function vinculin binding
Related Protein ACTN1; C22orf28; SORBS3; PXN; TLN1; CTNNA1; DAG1; SYNM; NRAP; DMD

Interacting Protein

TLN1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TLN1 here. Most of them are supplied by our site. Hope this information will be useful for your research of TLN1.
ITGB3; VCAM1; 1-phosphatidyl-1d-myo-inositol 4,5-bisphosphate; ITGB1; pip; EGFR; ERBB2; YWHAZ

TLN1 Related Articles

O'Rourke, DJ; DiJohnson, DA; et al. Autoantibody signatures as biomarkers to distinguish prostate cancer from benign prostatic hyperplasia in patients with increased serum prostate specific antigen. CLINICA CHIMICA ACTA 413:561-567(2012).
Hajagos, BE; Turetzky, JM; et al. Molecular Dissection of Novel Trafficking and Processing of the Toxoplasma gondii Rhoptry Metalloprotease Toxolysin-1. TRAFFIC 13:292-304(2012).