TLN1
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Official Full Name
talin 1
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Overview
Talin, a multifunctional constituent of cell-substratum attachment sites, is a high molecular weight protein (225-235 kDa) found in variety of tissues and cell types. It is localized at a subset of adherens junctions, specialized cell-cell and cell-matrix associations that are characterized by the presence of filamentous actin at the cytoplasmic face of the junctional complex. In cultured cells, talin is absent from cell-cell junctions and found predominantly at adhesion plaques and in fibrillar streaks underlying cell surface fibronectin. Talin interacts with at least two other proteins that are localized at adhesion plaques, vinculin and integrin. Talin and vinculin have been shown to interact with each other and both have been proposed to be involved in generating the transmembrane connection, between the extracellular matrix and the cytoskeleton, that occurs at adhesion plaques. At physiological ionic strength, talin is an elongate, flexible, monomeric protein with the ability to self-associate into dimers at higher protein concentrations. Talin 2 is related to talin 1. This protein has a different pattern of expression compared to talin 1 but, like talin 1, is thought to associate with unique transmembrane receptors to form novel linkages between extracellular matrices and the actin cytoskeleton. -
Synonyms
TLN1; talin 1; talin-1; Tln; MGC116305; Tln1;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Native Proteins
- Chicken
- Human
- Mouse
- Rat
- Turkey
- Zebrafish
- E.coli
- HEK293
- Mammalian Cell
- Turkey Smooth muscle
- Yeast
- GST
- His
- His (Fc)
- Avi
- N/A
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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Human | TLN1-3256H | Recombinant Human TLN1, His-tagged | E.coli | His | 2193-2541aa | |
Human | TLN1-354H | Recombinant Human TLN1 Protein, His-tagged | E.coli | His | Thr2293~Glu2536 | |
Human | TLN1-31442TH | Recombinant Human TLN1, His-tagged | E.coli | His | ||
Human | TLN1-353H | Recombinant Human TLN1 Protein, His-tagged | E.coli | His | Ala975-Ser1181 | |
Human | TLN1-1737H | Recombinant Human TLN1 Protein (92-399 aa), His-tagged | Yeast | His | 92-399 aa | |
Human | TLN1-4982H | Recombinant Human TLN1 protein, GST-tagged | E.coli | GST | 92-399aa | |
Human | TLN1-301604H | Recombinant Human TLN1 protein, GST-tagged | E.coli | GST | Gly2193-His2541 | |
Mouse | Tln1-355M | Recombinant Mouse Tln1 Protein, His-tagged | E.coli | His | Ala975~Ser1181 | |
Mouse | TLN1-16819M | Recombinant Mouse TLN1 Protein | Mammalian Cell | His | ||
Mouse | TLN1-9235M-B | Recombinant Mouse TLN1 Protein Pre-coupled Magnetic Beads | HEK293 | |||
Mouse | TLN1-9235M | Recombinant Mouse TLN1 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Rat | Tln1-356R | Recombinant Rat Tln1 Protein, His-tagged | E.coli | His | Ala975~Ser1181 | |
Turkey | TLN1-890T | Native Turkey TLN1 Protein | Turkey Smooth muscle | N/A | ||
Zebrafish | TLN1-1950Z | Recombinant Zebrafish TLN1 | Mammalian Cell | His | ||
Chicken | TLN1-6092C | Recombinant Chicken TLN1 | Mammalian Cell | His |
- Involved Pathway
- Protein Function
- Interacting Protein
- TLN1 Related Articles
- TLN1 Related Research Area
TLN1 involved in several pathways and played different roles in them. We selected most pathways TLN1 participated on our site, such as Rap signaling pathway, Focal adhesion, Platelet activation, which may be useful for your reference. Also, other proteins which involved in the same pathway with TLN1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Rap signaling pathway | BCAR1;NGFR;Itgam&Itgb2;CDH1;PIK3CG;VASP;PRKD2;CALM3;LPAR3 |
Focal adhesion | COL4A6;COL4A1;ACTG1;PPP1CA;ITGB5;BCL2;FYNA;RAC3;VAV1 |
Platelet activation | LCP2;ACTB;RAP1B;FGA;BTK;PTGIR;GNAS;P2RY12;MAPK12 |
HTLV-I infection | TGFBR1;HLA-DQA1;MRAS;TP53;BUB1B;RAN;HLA-DRA;TP53INP1;FOSL1 |
TLN1 has several biochemical functions, for example, LIM domain binding, actin filament binding, integrin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TLN1 itself. We selected most functions TLN1 had, and list some proteins which have the same functions with TLN1. You can find most of the proteins on our site.
Function | Related Protein |
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LIM domain binding | RPH3AL;LDB2B;CSRP2BP;LDB1A;TLN1;LDB2;RIPK2;LDB1;ACTN2 |
actin filament binding | WIPF2;ANXA8;TMOD1;MYH11;CAPZB;TULP1;FSCN3;MYO3A;CORO6 |
integrin binding | PXN;NF2;WISP1A;Npnt;CTGFB;ECM2;EGFL6;ADAM23;DST |
protein binding | AIM2;SEPHS1;PLAA;HDAC1;TSN;ZNF10;APOO;C14orf93;EIF2A |
structural constituent of cytoskeleton | ACTR2;TUBA8L;KRT16;CYLC1;AGRN;TUBB4A;ARPC4;TUBGCP3;TUBA2 |
vinculin binding | SORBS3;ACTN1;NRAP;PXN;CTNNA1;DMD;C22orf28;DAG1;SYNM |
TLN1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TLN1 here. Most of them are supplied by our site. Hope this information will be useful for your research of TLN1.
ITGB3; VCAM1; 1-phosphatidyl-1d-myo-inositol 4,5-bisphosphate; ITGB1; pip; EGFR; ERBB2; YWHAZ
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