ywhae
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  • Official Full Name
  • tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide
  • Background
  • 14-3-3 proteins are highly conserved proteins which play a role in both signal transduction and progression through the cell cycle by binding to and regulating several different proteins. 14-3-3 proteins activate tyrosine and tryptophan hydroxylases and protein kinase C. They mediate signal transduction by binding to phosphoserine containing proteins. There are at least 7 mammalian isoforms: alpha, beta, gamma, delta, epsilon, zeta, and eta. An eighth subtype, termed theta has been found in rat brain. The 14-3-3 proteins exists in vitro and in vivo as either homo- or heterodimers which interact via their N-terminal domains and are subject to phosphorylation by protein kinase C. 14-3-3 proteins are localized in the cytoplasm of neurons in the cerebral cortex and are axonally transported to the nerve terminals. They may be present at lower levels in various other eukaryotic tissues. Northern blot analysis has shown expression of the eta chain in cultured cell lines derived from various tumors.
  • Synonyms
  • YWHAE; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide; 14-3-3 protein epsilon; 14 3 3 epsilon; FLJ45465; 14-3-3 epsilon; protein kinase C inhibitor protein-1; mitochondrial import stimulation factor L subunit
Cat.#:YWHAE-150HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human YWHAE Protein, His-tagged
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Cat.#:YWHAE-1193MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse YWHAE, GST-tagged
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Cat.#:YWHAE-019HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human YWHAE Protein, His-tagged
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Cat.#:YWHAE-137HTag:His
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human YWHAE Protein, His-tagged
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Cat.#:YWHAE-26003THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human YWHAE
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Cat.#:YWHAE-26004THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human YWHAE
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Cat.#:YWHAE-26006THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human YWHAE
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Cat.#:YWHAE-873HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human YWHAE, None tagged
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Cat.#:YWHAE-878HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human YWHAE, GST tagged
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Cat.#:Ywhab-138MTag:His
Source (Host):Insect cellsSpecies:Mouse
Product nameRecombinant Mouse Ywhae Protein, His-tagged
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Cat.#:YWHAE-18683MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse YWHAE Protein
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Cat.#:YWHAE-888MTag:GST
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse YWHAE Protein, GST-tagged
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Cat.#:YWHAE-6638RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat YWHAE Protein
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Cat.#:YWHAE-1093CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus YWHAE Protein, His-tagged
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Cat.#:YWHAE-1367CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken YWHAE
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Cat.#:YWHAE-740HCLTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human YWHAE lysate
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Involved Pathway

YWHAE involved in several pathways and played different roles in them. We selected most pathways YWHAE participated on our site, such as Cell cycle, Oocyte meiosis, PIK-Akt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with YWHAE were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cell cycle
MDM2; ORC3L; ABL1; NCAPG; RAD17; E2F4; CCND2A; CTDNEP1A; RAD21; BRE
Oocyte meiosis
PRKACG; PPP2R5EA; PPP3CCB; PPP2R5E; PPP3R1; IGF1R; YWHAE; CALML5; SMC1A; PPP3CCA
PIK-Akt signaling pathway
Il6ra; LAMA5; RPS6KB2; PPP2R5E; PPP2R3C; SGK1; PDGFA; NFKB1; PPP2R2B; FLT4
Hippo signaling pathway
ACTG1; MPP5; BBC3; YWHAE; NF2; WNT2; CCND2; BMPR1A; PPP2R2B; WNT16
Neurotrophin signaling pathway
SHC4; RAF1; CALM1; BRAF; PIK3R3; RAP1B; ABL1; HRAS; CALM4; CAMK2A
Epstein-Barr virus infection
NCOR2; PSMC1; TBPL2; POLR2H; GTF2E2; EIF2AK2; RIPK1; NFKB2; YWHAG; IL10RA
Viral carcinogenesis
HDAC11; EGR3; SND1; HDAC3; GRB2; HIST1H4L; PSMC1; TRP53; HLA-B; GTF2H1

Protein Function

YWHAE has several biochemical functions, for example, MHC class II protein complex binding, enzyme binding, histone deacetylase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by YWHAE itself. We selected most functions YWHAE had, and list some proteins which have the same functions with YWHAE. You can find most of the proteins on our site.
Function
Related Protein
Function MHC class II protein complex binding
Related Protein HSP90AA1; CD81; CD74; MS4A1; ATP1B1; ANXA11; HLA-DRA; HLA-DMA; HSPA8; HLA-DOB
Function enzyme binding
Related Protein MDM4; SIRT1; MDM2; GRIN1; VAPB; NR5A1; HSPA6; PTPLAD2; KDM4C; TUT1
Function histone deacetylase binding
Related Protein HES1; ANKRD1; XBP1; CRY1; RFXANK; MEF2D; CDC20; YY1; HIST1H1B; TFAP4
Function ion channel binding
Related Protein CALM; FXYD1; AP2M1; RYR2; SLC14A2; DLG1; PACS1; PANX1; SRI; TCAP
Function phosphoprotein binding
Related Protein TRPV1; CSNK1D; TBL2; SFN; APTX; RB1; LRP11; MS4A2; YWHAB; DPYS
Function phosphoserine binding
Related Protein PIN1; YWHAE; NEDD4; YWHAB
Function poly(A) RNA binding
Related Protein RRP7A; RBM12; HRSP12; ERAL1; NOP2; HMGB2; ELAVL1; ASCC3; PATL1; ZFP36L1
Function potassium channel regulator activity
Related Protein ABCC9; KCNE1; SGK2; KCNAB1; KCNAB3; KCNIP1; AMIGO1; DRD4; DRD2; ARPP19A
Function protein binding
Related Protein IKZF1; RAN; GLS2; TLK2; PBX4; CAMLG; TIFA; USP4; SIX3; PIK3C3
Function protein domain specific binding
Related Protein YWHABB; HIST1H4E; TUBB; CNTLN; RAB27A; MED12; ZNF521; IST1; VCP; SCN5A
Function protein heterodimerization activity
Related Protein TAF12; TPD52; TCF3A; TYRO3; SCUBE1; VAPA; CLNS1A; ERBB3; TGFB2; BTBD11A
Function ubiquitin protein ligase binding
Related Protein SKI; PPARGC1A; FZD8; DBT; PDE4D; CHEK2; NGFR; NPLOC4; TOLLIP; UBE2O

Interacting Protein

YWHAE has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with YWHAE here. Most of them are supplied by our site. Hope this information will be useful for your research of YWHAE.
YWHAZ; LRRK2; HDAC4; ATXN1