ARHGEF1B
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
---|---|---|---|---|---|---|
Zebrafish | ARHGEF1B-3970Z | Recombinant Zebrafish ARHGEF1B | Mammalian Cell | His |
- Involved Pathway
- Protein Function
- Interacting Protein
ARHGEF1B involved in several pathways and played different roles in them. We selected most pathways ARHGEF1B participated on our site, such as Axonal growth inhibition (RHOA activation), G alpha (12/13) signalling events, GPCR downstream signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with ARHGEF1B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
---|---|
Axonal growth inhibition (RHOA activation) | ARHGEF1B;RTN4A;LINGO1;LINGO1B;OMG;RTN4 |
G alpha (12/13) signalling events | ABR;OBSCN;RHOGA;ARHGAP4A;ARHGEF18;RHOAE;ADRA1D;AKAP13;RHOB |
GPCR downstream signaling | NET1;OPN1LW1;OPN1MW2;ANXA1A;ADRA2C;CXCR6;INSL3;CHRM2;OR52B4 |
Signal Transduction | RGS1;RHOJ;DTX2;ASH2L;HHAT;METAP2B;LPAR2B;PAG1;CUL5A |
Signaling by GPCR | ANXA1A;RGS7;RGS4;MLN;RGS20;GAL;GNA13B;GPR39;INSL5 |
Signalling by NGF | PCSK5;DNAL4;RTN4A;KIDINS220B;PRDM4;RTN4;AATF;PCSK6;DNAL4A |
p75 NTR receptor-mediated signalling | RTN4;OMG;LINGO1B;LINGO1;ARHGEF1B;PRDM4;AATF;RTN4A |
p75NTR regulates axonogenesis | ARHGEF1B;OMG;RTN4;LINGO1B;LINGO1;RTN4A |
ARHGEF1B has several biochemical functions, for example, Rho guanyl-nucleotide exchange factor activity, guanyl-nucleotide exchange factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ARHGEF1B itself. We selected most functions ARHGEF1B had, and list some proteins which have the same functions with ARHGEF1B. You can find most of the proteins on our site.
Function | Related Protein |
---|---|
Rho guanyl-nucleotide exchange factor activity | DOCK9;DOCK11;FGD4A;ABR;ARHGEF17;FLJ20184;C9orf100;FGD1;ITSN2 |
guanyl-nucleotide exchange factor activity | FLCN;RAPGEF6;KNDC1;FGD3;ARFGEF1;TRIO;DOCK11;PCP2;ARHGEF7 |
ARHGEF1B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARHGEF1B here. Most of them are supplied by our site. Hope this information will be useful for your research of ARHGEF1B.
- Q&As
- Reviews
Q&As (10)
Ask a questionARHGEF1B has been identified in various species, including humans, primates, rodents, and zebrafish, suggesting its conservation across different organisms. The degree of conservation and functional similarities across species would require further investigation. Comparative studies may help to better understand the evolutionary significance and functional roles of ARHGEF1B in different organisms.
There is currently no known information regarding the involvement of ARHGEF1B in developmental processes. More research is necessary to determine if ARHGEF1B has any impact on development or if it is primarily involved in other cellular functions.
As of now, there are no known mouse models or knockout studies specifically targeting ARHGEF1B. However, this does not rule out the possibility of such studies being conducted in the future. Mouse models or knockout studies could provide valuable insights into the functional roles of ARHGEF1B in vivo and its potential implications in various biological processes or diseases.
Currently, there are no known disease associations specifically linked to ARHGEF1B mutations or dysregulation. However, given its similarity and interaction with ARHGEF1A, which has been implicated in diseases like cancer and neurological disorders, further investigations are warranted to explore the potential disease associations of ARHGEF1B.
The cellular processes and functions associated with ARHGEF1B have not been extensively studied. However, as a Rho GEF, it is likely involved in regulating cellular processes such as actin cytoskeleton organization, cell adhesion, cell migration, and cell proliferation. These processes are essential for various physiological and pathological processes, including development, tissue homeostasis, wound healing, and cancer metastasis. Further research is needed to determine the specific cellular functions and processes modulated by ARHGEF1B.
Currently, there is limited research on the specific role of ARHGEF1B in cancer. However, as ARHGEF1B is closely related to ARHGEF1A and they share similar functions and binding partners, it is conceivable that ARHGEF1B may also play a role in cancer progression and metastasis. Further studies are needed to explore the potential involvement of ARHGEF1B in cancer.
The known binding partners of ARHGEF1B include Rho GTPases, such as RhoA, Rac1, and Cdc42, which it interacts with to regulate various cellular processes. Additionally, ARHGEF1B has been found to bind to other proteins involved in cytoskeletal organization, cell adhesion, and signaling pathways, although the specifics are still being studied.
The therapeutic implications of targeting ARHGEF1B are currently unclear, primarily due to limited knowledge about its specific functions and involvement in diseases. However, as a regulator of Rho GTPases and potential role in cellular processes such as cell migration and invasion, ARHGEF1B could be a potential target for therapeutic interventions in diseases characterized by abnormal cell motility or cytoskeletal dynamics, such as cancer or neurological disorders. Further research is needed to explore the therapeutic potential of targeting ARHGEF1B.
The involvement of ARHGEF1B in neuronal development or function has not been extensively studied. However, since its related protein ARHGEF1A has been implicated in neuronal processes, it is plausible that ARHGEF1B may also have a role in neuronal development or function. Additional research is necessary to determine the specifics of ARHGEF1B's involvement in the nervous system.
Although limited, there is some evidence suggesting the involvement of ARHGEF1B in cell migration and invasion. As a regulator of Rho GTPases, ARHGEF1B has the potential to modulate cytoskeletal dynamics, which are critical for these processes. However, more research is needed to fully elucidate the extent of ARHGEF1B's involvement in cell migration and invasion.
Customer Reviews (8)
Write a reviewWith the ARHGEF1B protein and the manufacturer's assistance, my trials have been empowered to yield impactful findings, contributing to advancements in the field of biomedical research.
Whether it is regarding experimental design, optimization of protocols, or troubleshooting issues, their expertise and prompt customer service help researchers overcome challenges efficiently.
The protein's unique properties allow researchers to gain insights into the underlying mechanisms and explore potential therapeutic interventions.
the excellent technical support provided by the manufacturer is of immense value to me.
The ability to customize the ARHGEF1B protein variants or modifications offered by the manufacturer is also advantageous, as it allows me to tailor the protein to my specific research objectives.
Additionally, cost-effectiveness, competitive pricing, and bulk purchase options can also be advantageous for researchers working within limited budgets.
I appreciate the manufacturer's commitment to maintaining exceptional protein quality standards, which ensures reliable and consistent results in my trials.
They continuously invest in research and development, ensuring that their offerings remain at the forefront of scientific advancements.
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