AGL
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Official Full Name
amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase
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Overview
This gene encodes the glycogen debrancher enzyme which is involved in glycogen degradation. This enzyme has two independent catalytic activities which occur at different sites on the protein: a 4-alpha-glucotransferase activity and a amylo-1,6-glucosidase activity. Mutations in this gene are associated with glycogen storage disease although a wide range of enzymatic and clinical variability occurs which may be due to tissue-specific alternative splicing. Alternatively spliced transcripts encoding different isoforms have been described. -
Synonyms
AGL; amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase; amylo 1, 6 glucosidase, 4 alpha glucanotransferase; glycogen debranching enzyme; glycogen storage disease type III; 9430004C13Rik; 9630046L06Rik; AI850929; C77197; 1110061O17Rik; Amylo 1 6 glucosidase 4 alpha glucanotransferase; GDE; Glycogen debrancher; amylo-1, 6-glucosidase, 4-alpha-glucanotransferase;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- E. coli
- E.coli
- HEK293
- HEK293T
- Mammalian cells
- C
- His
- Flag
- GST
- His (Fc)
- Avi
- His|T7
- Myc
- DDK
- Myc|DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- AGL Related Articles
AGL involved in several pathways and played different roles in them. We selected most pathways AGL participated on our site, such as Glucose metabolism, Glycogen Metabolism, Glycogen breakdown (glycogenolysis), which may be useful for your reference. Also, other proteins which involved in the same pathway with AGL were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Glucose metabolism | GYG1A;PFKLB;SLC25A1A;AGL;GYG2;SLC25A10;SLC25A1;EPM2A;GYG1 |
| Glycogen Metabolism | GYG2;GSK3AB;GYG1;AGL |
| Glycogen breakdown (glycogenolysis) | GYG2;GYG1;AGL;GYG1B;GYG1A;PYGMB |
| Metabolic pathways | PLCB2;PFKM;PANK3;GATC;IDH3A;ALAS1;SYNJ2;UQCRB;RDH10A |
| Metabolism | CPT2;SLC27A2A;ACSM1;B3GNT3;PLBD1;DCT;PTPMT1;MMADHC;NUDT5 |
| Metabolism of carbohydrates | EPM2A;MAPK1IP1L;SLC35B2;HS3ST4;GLB1L;HPSE;DSEL;SLC35D2;LYVE1 |
| Starch and sucrose metabolism | PYGMA;UGP2;UXS1;UGT1A7C;UGDH;GPI1;GAA;PGM2L1;AMY1B |
AGL has several biochemical functions, for example, 4-alpha-glucanotransferase activity, amylo-alpha-1,6-glucosidase activity, glycogen debranching enzyme activity. Some of the functions are cooperated with other proteins, some of the functions could acted by AGL itself. We selected most functions AGL had, and list some proteins which have the same functions with AGL. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| 4-alpha-glucanotransferase activity | AGLA;AGL |
| amylo-alpha-1,6-glucosidase activity | AGL;AGLA |
| glycogen debranching enzyme activity | |
| polysaccharide binding | CLEC18C;VTNA;ENDOU;CD209B;PRG4A;CLEC4G;GM106;VTNB;PRG4B |
| polyubiquitin binding | DZIP3;RAD23B;UBQLN4;PSMD4B;RAD18;RAD23A;UBQLN1;BAG6;THRSP |
| protein binding | KSR1;ARHGEF2;TNFRSF6B;RC3H2;FKBP8;HPX;LCORL;CNBP;TSPAN12 |
AGL has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AGL here. Most of them are supplied by our site. Hope this information will be useful for your research of AGL.
PRKAB2; PRKAA2; RASSF5; APPL1; GABARAPL2; CBX1; SMAD3; Ppp1r3b; GABARAPL1; UVRAG; SH3GLB1
- Q&As
- Reviews
Q&As (20)
Ask a questionYes, AGL mutations can cause low blood sugar levels due to impaired glucose release.
AGL mutations might contribute to cardiomyopathy due to glycogen accumulation.
Yes, AGL mutations can lead to muscle weakness due to impaired glycogen breakdown.
Research explores whether AGL's function is conserved in different organisms.
AGL activity ensures proper glycogen breakdown, maintaining cellular glycogen levels.
Yes, ongoing research uncovers AGL's roles in metabolism and related diseases.
AGL's enzymatic activity alters glycogen structure by removing branches.
AGL's role in glycogen metabolism makes it a potential therapeutic target.
AGL's enzymatic role is in breaking down glycogen, not synthesizing it.
AGL dysfunction can affect various tissues due to glycogen storage disruptions.
AGL deficiency affects muscle cells due to impaired glycogen breakdown.
Research on AGL provides insights into glycogen metabolism and related diseases.
Yes, hormones regulate AGL activity to maintain glucose levels.
Yes, AGL's role in glycogen breakdown can impact heart function and health.
AGL's role in glycogen breakdown helps maintain glucose homeostasis.
Yes, AGL deficiency is usually inherited in an autosomal recessive manner.
AGL deficiency hinders glucose release from glycogen, affecting energy supply.
Yes, AGL mutations can impact exercise tolerance due to limited energy supply.
Yes, AGL mutations can impact multiple organs due to glycogen storage issues.
AGL mutations can impact brain health due to glycogen storage issues in certain tissues.
Customer Reviews (5)
Write a reviewNotable improvements in cell proliferation were attributed to the protein product’s efficacy.
We observed a significant enhancement in enzyme activity using the protein product.
The protein product’s compatibility with various assays broadened the scope of our investigations.
Reliable protein-protein interaction studies were enabled by the protein product’s pure composition.
Minimal background noise in our assays indicated the protein product’s quality.
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