Recombinant Human AGL protein(731-830 aa), C-His-tagged

• Cat.No.: AGL-2739H
• Product Overview: Recombinant Human AGL protein(P35573)(731-830 aa), fused with C-terminal His tag, was expressed in E. coli.

Specification

• Source: E. coli
• Species: Human
• Tag: His
• Protein length: 731-830 aa
• Form: 0.15 M Phosphate buffered saline
• AASequence: AVTRHSPSIHQSVVAVSRTAFRNPK TSFYSKEVPQMCIPGKIEEVVLEAR TIERNTKPYRKDENSINGTPDITVE IREHIQLNESKIVKQAGVATKGPNE
• Storage: Shipped on dry ice. Avoid repeated freeze-thaw cycles. Upon receipt, 2 days when stored at 2 to 8 °C after thawing.
  Up to 12 months when aliquoted and stored at -20 to -80°C.
• Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4°C before opening to recover the entire contents.

Gene Information

• Gene Name: AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase [ Homo sapiens ]
• Official Symbol: AGL
• Synonyms: AGL; amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase; amylo 1, 6 glucosidase, 4 alpha glucanotransferase; glycogen debranching enzyme; glycogen storage disease type III; glycogen debrancher; amylo-1, 6-glucosidase, 4-alpha-glucanotransferase; GDE
• Gene ID: 178
• mRNA Refseq: NM_000028
• Protein Refseq: NP_000019
• MIM: 610860
• UniProt ID: P35573

Reviews

05/17/2019

 Notable improvements in cell proliferation were attributed to the protein product’s efficacy.

11/30/2018

 We observed a significant enhancement in enzyme activity using the protein product.

09/11/2018

 The protein product’s compatibility with various assays broadened the scope of our investigations.

08/25/2017

 Reliable protein-protein interaction studies were enabled by the protein product’s pure composition.

08/20/2017

 Minimal background noise in our assays indicated the protein product’s quality.

Q&As

Can AGL mutations lead to hypoglycemia?

Yes, AGL mutations can cause low blood sugar levels due to impaired glucose release.

Can AGL mutations lead to cardiomyopathy?

AGL mutations might contribute to cardiomyopathy due to glycogen accumulation.

Can AGL mutations cause muscle weakness?

Yes, AGL mutations can lead to muscle weakness due to impaired glycogen breakdown.

Is AGL's role conserved across species?

Research explores whether AGL's function is conserved in different organisms.

How does AGL influence cellular glycogen stores?

AGL activity ensures proper glycogen breakdown, maintaining cellular glycogen levels.

Is AGL research ongoing?

Yes, ongoing research uncovers AGL's roles in metabolism and related diseases.

How does AGL contribute to glycogen structure?

AGL's enzymatic activity alters glycogen structure by removing branches.

Can AGL be a target for therapeutic interventions?

AGL's role in glycogen metabolism makes it a potential therapeutic target.

How does AGL influence glycogen synthesis?

AGL's enzymatic role is in breaking down glycogen, not synthesizing it.

How does AGL dysfunction impact different tissues?

AGL dysfunction can affect various tissues due to glycogen storage disruptions.

How does AGL deficiency impact muscle cells?

AGL deficiency affects muscle cells due to impaired glycogen breakdown.

What's the significance of AGL research?

Research on AGL provides insights into glycogen metabolism and related diseases.

Is AGL activity regulated by hormones?

Yes, hormones regulate AGL activity to maintain glucose levels.

Is AGL involved in heart health?

Yes, AGL's role in glycogen breakdown can impact heart function and health.

How does AGL contribute to metabolic homeostasis?

AGL's role in glycogen breakdown helps maintain glucose homeostasis.

Is AGL deficiency inherited?

Yes, AGL deficiency is usually inherited in an autosomal recessive manner.

How does AGL deficiency impact energy availability?

AGL deficiency hinders glucose release from glycogen, affecting energy supply.

Can AGL mutations affect exercise tolerance?

Yes, AGL mutations can impact exercise tolerance due to limited energy supply.

Can AGL mutations lead to multi-organ involvement?

Yes, AGL mutations can impact multiple organs due to glycogen storage issues.

Can AGL mutations affect brain function?

AGL mutations can impact brain health due to glycogen storage issues in certain tissues.