DAXX
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Official Full Name
death-domain associated protein
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Overview
Daxx is a ubiquitously expressed protein that was originally identified through a yeast two-hybrid screen as an interactor with the cytoplasmic domain of Fas. It was found to enhance Fas-mediated apoptosis and activate the JNK pathway (1). However, additi -
Synonyms
DAXX; death-domain associated protein; death associated protein 6; death domain-associated protein 6; DAP6; Fas-binding protein; CENP-C binding protein; ETS1-associated protein 1; death-associated protein 6; fas death domain-associated protein; EAP1; BING2; MGC126245; MGC126246;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Zebrafish
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- C
- Myc
- DDK
- Flag
- GST
- His
- His (Fc)
- Avi
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- DAXX Related Articles
- DAXX Related Research Area
- DAXX Related Signal Pathway
DAXX involved in several pathways and played different roles in them. We selected most pathways DAXX participated on our site, such as Amyotrophic lateral sclerosis (ALS), Androgen receptor signaling pathway, Apoptosis Modulation and Signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with DAXX were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Amyotrophic lateral sclerosis (ALS) | PPP3R1;CCS;GRIN2C;PPP3CC;TNFRSF1B;GRIN2A;NEFM;SOD1;TRP53 |
Androgen receptor signaling pathway | ETV5A;RNF6;TGFB1I1;CARM1;KAT7B;RNF14;KAT7;SVILA;RNF4 |
Apoptosis Modulation and Signaling | BOK;CDKN2A;HN1;BLK;CRADD;DAXX;BCL2L10;DIABLO;PTRH2 |
FAS pathway and Stress induction of HSP regulation | LMNB2;DAXX;FAF1;DFFA |
HIV-1 Nef: Negative effector of Fas and TNF-alpha | CRADD;DFFA;DAXX;CASP2 |
Herpes simplex infection | IKBKB;SRSF6A;HNRNPK;CCL5;HLA-DPA1;IFNG1-2;TAF3;PPP1CB;MAPK9 |
IL-6 Signaling Pathway | CDK5R1B;EIF2A;DAXX;BMX |
Integrated Pancreatic Cancer Pathway | TFF1;MYT1;CD82;CST3;TOP2A;JUND;FST;MAPK4;IL11 |
DAXX has several biochemical functions, for example, androgen receptor binding, enzyme binding, heat shock protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DAXX itself. We selected most functions DAXX had, and list some proteins which have the same functions with DAXX. You can find most of the proteins on our site.
Function | Related Protein |
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androgen receptor binding | NRIP1;RNF14;RNF4;RNF6;BRCA1;PKN1;TGFB1I1;DAXX;FOXH1 |
enzyme binding | SPDL1;CYB5A;TSPYL1;KDM1A;CCND1;HINFP;ESR2;MST1R;PRKCA |
heat shock protein binding | SSUH2.2;CDC37L1;NFKB1;GRXCR2;PDXP;HDAC2;DLST;SSUH2RS1;IRAK1 |
histone binding | PRKCBB;SUPT6H;RNF20;NPM2;HIST1H3F;PRMT7;NCAPD3;ASF1A;PRKCB |
p53 binding | TP63;ZNF346;KDM1A;ZNF385C;DAXX;CDKN2AIP;MDM2;TRIAP1;BRD4 |
protein N-terminus binding | TSC1;EIF5A;CHMP6;UNC13A;NPAT;SMARCA4;NTSR1;TRP53;ERCC4 |
protein binding | CDON;KIF4A;CYLD;MARCH5;ZFPM1;EIF4A1;ABLIM3;RPS15;PREP |
protein homodimerization activity | SQSTM1;HNF1A;ASNS;DARS2;SH3GLB1;TYW5;ZBTB1;ZHX2;TIRAP |
protein kinase activator activity | FAM58A;DBF4B;PRKAG2;STRADA;PIK3CA;NKX3-1;MT3;FGF13;GPRC5B |
protein kinase binding | MAP3K5;CD226;CLTC;CDC25A;SUFU;PAK2;CADPS;PKD1;CCNYL1 |
receptor signaling protein activity | CD3E;DCLK1;ADCYAP1;RAF1B;ADRB1;FCGR1A;ARAF;FLRT3;Siglece |
transcription corepressor activity | WTIP;ZNF274;CTCF;HIRA;ID4;GPS2;JAZF1;HOMEZA;HDAC7A |
transcription factor binding | PAX6;AHR;HDAC2;UBA2;PDCD11;CDK9;MYOD1;HES3;CHCHD2 |
ubiquitin protein ligase binding | PPARGC1A;TNFRSF14;LC3;POU5F1;PTPN22;FANCL;RALB;HSPD1;UBE2B |
DAXX has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DAXX here. Most of them are supplied by our site. Hope this information will be useful for your research of DAXX.
MDM2; TP53
- Q&As
- Reviews
Q&As (5)
Ask a questionDAXX protein interacts with a wide range of cellular proteins, including transcription factors, histones, and chromatin remodeling complexes, which has implications for its clinical relevance in various cellular processes.
Targeting DAXX protein may have therapeutic implications in cancer treatment, as well as in aging-related diseases and neurodegenerative disorders, by modulating its functions and interactions with other cellular proteins.
Studies have suggested that DAXX protein may have implications in aging-related diseases, particularly in relation to telomere dysfunction and cellular senescence.
DAXX protein has been implicated in neurodegenerative diseases through its involvement in cellular stress responses and protein aggregation, which are hallmarks of diseases such as Alzheimer's and Parkinson's.
DAXX protein has been identified as a potential therapeutic target for cancer treatment due to its involvement in regulating the activity of key oncogenes and tumor suppressor genes.
Customer Reviews (3)
Write a reviewIts ability to provide accurate and reliable results in this particular application makes it a preferred choice for researchers studying antigen-antibody interactions and immune responses.
The DAXX protein's sensitivity and specificity ensure precise measurements, contributing to the overall success of ELISA experiments.
the DAXX protein has proven to be invaluable in protein electron microscopy structure analysis.
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