| Description : |
This gene encodes a multifunctional protein that resides in multiple locations in the nucleus and in the cytoplasm. It interacts with a wide variety of proteins, such as apoptosis antigen Fas, centromere protein C, and transcription factor erythroblastosis virus E26 oncogene homolog 1. In the nucleus, the encoded protein functions as a potent transcription repressor that binds to sumoylated transcription factors. Its repression can be relieved by the sequestration of this protein into promyelocytic leukemia nuclear bodies or nucleoli. This protein also associates with centromeres in G2 phase. In the cytoplasm, the encoded protein may function to regulate apoptosis. The subcellular localization and function of this protein are modulated by post-translational modifications, including sumoylation, phosphorylation and polyubiquitination. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2008] |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
82.7 kDa |
| AA Sequence : |
MRGSENCGEGRLERRFLSIIVLDDD DEDEAAAQPGPSHPLPNAASPGAEA PSSSEPHGARGSSSSGGKKCYKLEN EKLFEEFLELCKMQTADHPEVVPFL YNRQQRAHSLFLASAEFCNILSRVL SRARSRPAKLYVYINELCTVLKAHS AKKKLNLAPAATTSNEPSGNNPPTH LSLDPTNAENTASQSPRTRGSRRQI QRLEQLLALYVAEIRRLQEKELDLS ELDDPDSAYLQEARLKRKLIRLFGR LCELKDCSSLTGRVIEQRIPYRGTR YPEVNRRIERLINKPGPDTFPDYGD VLRAVEKAAARHSLGLPRQQLQLMA QDAFRDVGIRLQERRHLDLIYNFGC HLTDDYRPGVDPALSDPVLARRLRE NRSLAMSRLDEVISKYAMLQDKSEE GERKKRRARLQGTSSHSADTPEASL DSGEGPSGMASQGCPSASRAETDDE DDEESDEEEEEEEEEEEEEATDSEE EEDLEQMQEGQEDDEEEDEEEEAAA GKDGDKSPMSSLQISNEKNLEPGKQ ISRSSGEQQNKGRIVSPSLLSEEPL APSSIDAESNGEQPEELTLEEESPV SQLFELEIEALPLDTPSSVETDISS SRKQSEEPFTTVLENGAGMVSSTSF NGGVSPHNWGDSGPPCKKSRKEKKQ TGSGPLGNSYVERQRSVHEKNGKKI CTLPSPPSPLASLAPVADSSTRVDS PSHGLVTSSLCIPSPARLSQTPHSQ PPRPGTCKTSVATQCDPEEIIVLSD SDTRTRPLEQKLISEEDLAANDILD YKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
