DMBT1
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Official Full Name
deleted in malignant brain tumors 1
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Overview
Loss of sequences from human chromosome 10q has been associated with the progression of human cancers.The gene DMBT1 was originally isolated based on its deletion in a medulloblastoma cell line.DMBT1 is expressed with transcripts of 6.0, 7.5, and 8.0 kb in fetal lung and with one transcript of 8.0 kb in adult lung, although the 7.5 kb transcript has not been characterized.The DMBT1 protein is a glycoprotein containing multiple scavenger receptor cysteine-rich (SRCR) domains separated by SRCR-interspersed domains (SID).Transcript variant 2 (8.0 kb) has been shown to bind surfactant protein D independently of carbohydrate recognition.This indicates that DMBT1 may not be a classical tumor supressor gene, but rather play a role in the interaction of tumor cells and the immune system. -
Synonyms
DMBT1; deleted in malignant brain tumors 1; deleted in malignant brain tumors 1 protein; GP340; muclin; SAG; gp-340; hensin; glycoprotein 340; salivary agglutinin; surfactant pulmonary-associated D-binding protein; FLJ61058; MGC164738;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- E.coli
- HEK293
- Human Cell
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- N/A
- N
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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Human | DMBT1-3231H | Recombinant Human DMBT1, His tagged | Human Cell | His | ||
Human | DMBT1-26786TH | Recombinant Human DMBT1 | Wheat Germ | N/A | 109 amino acids | |
Human | DMBT1-2700H | Recombinant Human DMBT1 Protein, GST-tagged | Wheat Germ | GST | ||
Human | DMBT1-2407HCL | Recombinant Human DMBT1 cell lysate | Human Cell | N/A | ||
Human | DMBT1-1351H | Recombinant Human DMBT1 Protein, His-tagged | E.coli | N-His | Cys2008-Arg2413 | |
Mouse | DMBT1-4641M | Recombinant Mouse DMBT1 Protein | Mammalian Cell | His | ||
Mouse | DMBT1-2409M-B | Recombinant Mouse DMBT1 Protein Pre-coupled Magnetic Beads | HEK293 | |||
Mouse | DMBT1-2409M | Recombinant Mouse DMBT1 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Rat | DMBT1-1890R | Recombinant Rat DMBT1 Protein | Mammalian Cell | His | ||
Rat | DMBT1-1549R-B | Recombinant Rat DMBT1 Protein Pre-coupled Magnetic Beads | HEK293 | |||
Rat | DMBT1-1549R | Recombinant Rat DMBT1 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
- Involved Pathway
- Protein Function
- Interacting Protein
- DMBT1 Related Articles
- DMBT1 Related Research Area
DMBT1 involved in several pathways and played different roles in them. We selected most pathways DMBT1 participated on our site, such as Metabolism of proteins, Salivary secretion, Surfactant metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with DMBT1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Metabolism of proteins | GPR116;IGFALS;MUCL1;DPH3;SPON2;CPA3;MTX1;B3GALTL;SPCS3 |
Salivary secretion | ITPR3;ATP1A2;PLCB1;VAMP2;LYZ;CD38;DMBT1;ATP2B1;RYR3 |
Surfactant metabolism | LMCD1;SLC34A2A;DMBT1;SFTPC;CKAP4;SFTPBB;CCDC59;GATA6;CTSH |
DMBT1 has several biochemical functions, for example, calcium-dependent protein binding, protein binding, scavenger receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DMBT1 itself. We selected most functions DMBT1 had, and list some proteins which have the same functions with DMBT1. You can find most of the proteins on our site.
Function | Related Protein |
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calcium-dependent protein binding | SEC31A;ANXA2;STX2;MYO1D;ANXA7;NRXN1;VLDLR;STMN2;CHP |
protein binding | ZFAND6;RAB6A;COPG;RUVBL1;TTC30B;FAM164A;NDUFB10;LYAR;FAM103A1 |
scavenger receptor activity | TMPRSS3;MARCO;LGALS3BPA;HHIPL1;TMPRSS4B;SCARF2;TINAG;POLR1B;ENPP2 |
signaling pattern recognition receptor activity | MARCO;TLR2;FCN1;TRIM5;DMBT1;COLEC12;CLEC7A |
zymogen binding |
DMBT1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DMBT1 here. Most of them are supplied by our site. Hope this information will be useful for your research of DMBT1.
CAV1; CDK5RAP3; P/V/C; CDK6; PARD6B
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