dsp
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  • Official Full Name
  • desmoplakin
  • Background
  • Desmosomes are intercellular junctions that tightly link adjacent cells. Desmoplakin is an obligate component of functional desmosomes that anchors intermediate filaments to desmosomal plaques. The N-terminus of desmoplakin is required for localization to the desmosome and interacts with the N-terminal region of plakophilin 1 and plakoglobin. The C-terminus of desmoplakin binds with intermediate filaments. In the mid-region of desmoplakin, a coiled-coiled rod domain is responsible for homodimerization. Mutations in this gene are the cause of several cardiomyopathies and keratodermas as well as the autoimmune disease paraneoplastic pemphigus. [provided by RefSeq, Jul 2008]
  • Synonyms
  • DSP; desmoplakin; DP; DPI; DPII; desmoplakin I; desmoplakin II; 250/210 kDa paraneoplastic pemphigus antigen;
Cat.#:DSP-1195HTag:His-SUMO
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human DSP Protein, His-SUMO-tagged
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Cat.#:DSP-401HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human DSP Protein, His-tagged
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Cat.#:DSP-12182HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human DSP, GST-tagged
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Involved Pathway

DSP involved in several pathways and played different roles in them. We selected most pathways DSP participated on our site, such as Alpha6-Beta4 Integrin Signaling Pathway, Apoptosis, Apoptotic cleavage of cell adhesion proteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with DSP were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Alpha6-Beta4 Integrin Signaling Pathway
MST1R; EIF4EB; CD151L; EIF4E; PLEC; DST; YWHAQ; CLCA1; CD151; COL17A1
Apoptosis
XIAP; CYCS; BOKA; LMNB1; SPNA2; PIK3R5; TNFRSF10B; CASP2; TNFRSF1A; DERL3
Apoptotic cleavage of cell adhesion proteins
DSG2; DSP; CTNNB1; DSG3; DSG1; PKP1; OCLN; PTBP3; CTNNB2
Apoptotic cleavage of cellular proteins
VIML; GAS2; BMX; CASP8L1; LMNB1; CASP6L2; DSG3; DBNLB; OCLN; STK24
Apoptotic execution phase
DNM1L; SATB1; STK24B; GAS2; CASP8L1; DBNL; HMGB2A; CTNNB2; HIST1H1B; CASP6L1
Arrhythmogenic right ventricular cardiomyopathy
CDH2; JUP; DES; DSC2; CACNG3; DMD; DSP; CTNNA1; DSG2; DAG1
Arrhythmogenic right ventricular cardiomyopathy (ARVC)
LMNA; ITGB6; ACTG1; TCF7L2; ITGA10; CACNB4; CTNNA1; CACNG4; SGCB; ACTB
Programmed Cell Death
RNF8; STK26; VIML; STK24A; GZMF; DSP; DAPK3; MLKL; GZME; PLECA

Protein Function

DSP has several biochemical functions, for example, cell adhesion molecule binding, cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication, poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DSP itself. We selected most functions DSP had, and list some proteins which have the same functions with DSP. You can find most of the proteins on our site.
Function
Related Protein
Function cell adhesion molecule binding
Related Protein DSP; NLGN2; NLGN1; VCAM1; CADM1; DSG2; NLGN4Y; SELL; NCR3; CADM3
Function cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication
Related Protein PKP2; DSP; DSG2; JUP; CTNNA3; DSC2
Function poly(A) RNA binding
Related Protein UBAP2L; RBM5; PNN; SRPK1; CCDC137; Cstb; DIMT1; DHX8; RALY; RBM39
Function protein binding
Related Protein PPP3R2; CENPP; EZR; ZSCAN16; AXIN2; POP5; ITM2A; LRRC33; FXN; TRIM29
Function protein binding, bridging
Related Protein FGB; ST13; STUB1; SYNM; MMS19; CAV2; AMFR; ANXA1; IVL; BCL3
Function protein kinase C binding
Related Protein GRK5; SDPR; AVPR1A; PKP2; PDLIM5; AKT2; NELL2; PARD6A; DSP; TOP2B
Function scaffold protein binding
Related Protein PARK7; DLG4; CAV2; SHANK1; KCNA5; NLGN3; KRT15; CIT; GRIN2A; SHANK3
Function structural constituent of cytoskeleton
Related Protein TUBB4B; DES; ATXN1; BFSP1; TPM1; SPTBN2; KRT17; PLS1; KRT2; AGRN
Function structural molecule activity
Related Protein NEFMB; DESMB; Sprr2i; CDC42SE2; CRYBB2; CLTCA; SPRR2H; NPHP1; KRT35; ISCA1

Interacting Protein

DSP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DSP here. Most of them are supplied by our site. Hope this information will be useful for your research of DSP.
MAPRE1; JUP; PKP2; q76353_9hiv1; PECAM1; NFKB2; PSTPIP1; SSSCA1

DSP Related Articles

Paul, AJ; Schwab, K; et al. Direct analysis of mAb aggregates in mammalian cell culture supernatant. BMC BIOTECHNOLOGY 14:-(2014).
Campbell, K; McNamee, SE; et al. Evolving to the optoelectronic mouse for phycotoxin analysis in shellfish. ANALYTICAL AND BIOANALYTICAL CHEMISTRY 406:6867-6881(2014).