dsp
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  • Official Full Name
  • desmoplakin
  • Background
  • Desmosomes are intercellular junctions that tightly link adjacent cells. Desmoplakin is an obligate component of functional desmosomes that anchors intermediate filaments to desmosomal plaques. The N-terminus of desmoplakin is required for localization to the desmosome and interacts with the N-terminal region of plakophilin 1 and plakoglobin. The C-terminus of desmoplakin binds with intermediate filaments. In the mid-region of desmoplakin, a coiled-coiled rod domain is responsible for homodimerization. Mutations in this gene are the cause of several cardiomyopathies and keratodermas as well as the autoimmune disease paraneoplastic pemphigus. [provided by RefSeq, Jul 2008]
  • Synonyms
  • DSP; desmoplakin; DP; DPI; DPII; desmoplakin I; desmoplakin II; 250/210 kDa paraneoplastic pemphigus antigen;
Cat.#:DSP-1195HTag:His-SUMO
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human DSP Protein, His-SUMO-tagged
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Cat.#:DSP-401HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human DSP Protein, His-tagged
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Cat.#:DSP-12182HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human DSP, GST-tagged
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Involved Pathway

DSP involved in several pathways and played different roles in them. We selected most pathways DSP participated on our site, such as Alpha6-Beta4 Integrin Signaling Pathway, Apoptosis, Apoptotic cleavage of cell adhesion proteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with DSP were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Alpha6-Beta4 Integrin Signaling Pathway
EIF4EBP1; EIF4EB; CDKN1A; EIF4E; SMAD3B; NTN1A; CD151L; PLEC; MST1R; RTKN
Apoptosis
CTNNB2; DBNL; ENDOG; E2F1; GZMC; RNF8; CRADD; IL1RAP; TNFRSF10D; BIRC8
Apoptotic cleavage of cell adhesion proteins
DSP; OCLN; PTBP3; DSG1; CTNNB1; DSG3; CTNNB2; DSG2; PKP1
Apoptotic cleavage of cellular proteins
CASP8L1; CLSPN; DBNLB; DSG3; BMX; BCAP31; OCLN; VIML; DSP; GAS2
Apoptotic execution phase
PLEC; DFFA; CASP6L2; LMNB1; PTBP3; DNM1L; DBNLB; BCAP31; VIML; CTNNB2
Arrhythmogenic right ventricular cardiomyopathy
DSG2; CDH2; JUP; DAG1; CACNG3; DSC2; CACNG2; DSP; DMD; DES
Arrhythmogenic right ventricular cardiomyopathy (ARVC)
ITGB4; EMD; JUP; CACNG6; CTNNA2; CACNB2; TCF7L2; GJA1; CACNB3; CACNG3
Programmed Cell Death
STK24A; STK24B; ADD1; DIABLO; DSG2; CASP6L1; GZMF; GZMC; GAS2; PANK1A

Protein Function

DSP has several biochemical functions, for example, cell adhesion molecule binding, cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication, poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DSP itself. We selected most functions DSP had, and list some proteins which have the same functions with DSP. You can find most of the proteins on our site.
Function
Related Protein
Function cell adhesion molecule binding
Related Protein PVRL4; NPTN; GLYCAM1; ITGB2; PTBP3; CADM4; CADM1; NRXN1; CADM3; CD200
Function cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication
Related Protein DSG2; CTNNA3; DSP; DSC2; JUP; PKP2
Function poly(A) RNA binding
Related Protein ZCCHC3; FKBP3; MAGOH; PRPF6; FDPS; GANAB; EXOSC6; CPSF4; MATR3; METTL16
Function protein binding
Related Protein UCHL5; STX11; TIMM10; CDKL3; CEP76; POLR3F; NTRK1; ZNF695; HMGN2; MYO10
Function protein binding, bridging
Related Protein TIRAP; SPRR1A; SH2D1B; CUX1; CNKSR1; SPRR1B; TRIM6; GATAD2A; ANXA1; CNTLN
Function protein kinase C binding
Related Protein MARCKS; TOP2B; SDPR; PEA15A; AVPR1B; LDB3; CASQ2; FEZ1; AKT1; UGT1A7
Function scaffold protein binding
Related Protein KRT18; NLRP1; NLGN4X; ATP2B4; CIT; KRT8; CACNA1H; NOS3; HOMER1; PDE4D
Function structural constituent of cytoskeleton
Related Protein KRT16; TUBA3D; TUBGCP2; TUBA3C; KRT71; EPB41L4B; DES; KRT6B; TPM1; PLS1
Function structural molecule activity
Related Protein KRT94; SPRR2A; COPG2; CLDNE; KRT28; SPRR2G; KLHL3; Sprr2i; KRT25; CLDN22

Interacting Protein

DSP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DSP here. Most of them are supplied by our site. Hope this information will be useful for your research of DSP.
MAPRE1; JUP; PKP2; q76353_9hiv1; PECAM1; NFKB2; PSTPIP1; SSSCA1

DSP Related Articles

Paul, AJ; Schwab, K; et al. Direct analysis of mAb aggregates in mammalian cell culture supernatant. BMC BIOTECHNOLOGY 14:-(2014).
Campbell, K; McNamee, SE; et al. Evolving to the optoelectronic mouse for phycotoxin analysis in shellfish. ANALYTICAL AND BIOANALYTICAL CHEMISTRY 406:6867-6881(2014).