Recombinant Human DSP, GST-tagged

• Cat.No.: DSP-12182H
• Product Overview: Recombinant Human DSP protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.

Specification

• Species: Human
• Source: E.coli
• Tag: GST
• Protein Length: 1-350a.a.
• Description: Desmosomes are intercellular junctions that tightly link adjacent cells. Desmoplakin is an obligate component of functional desmosomes that anchors intermediate filaments to desmosomal plaques. The N-terminus of desmoplakin is required for localization to the desmosome and interacts with the N-terminal region of plakophilin 1 and plakoglobin. The C-terminus of desmoplakin binds with intermediate filaments. In the mid-region of desmoplakin, a coiled-coiled rod domain is responsible for homodimerization. Mutations in this gene are the cause of several cardiomyopathies and keratodermas as well as the autoimmune disease paraneoplastic pemphigus.
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.

Gene Information

• Gene Name: DSP desmoplakin [ Homo sapiens ]
• Official Symbol: DSP
• Synonyms: DSP; desmoplakin; desmoplakin (DPI, DPII); DPI; DPII; KPPS2; PPKS2; desmoplakin I; desmoplakin II; 250/210 kDa paraneoplastic pemphigus antigen; DP
• Gene ID: 1832
• mRNA Refseq: NM_001008844
• Protein Refseq: NP_001008844
• MIM: 125647
• UniProt ID: P15924
• Chromosome Location: 6pter-p21
• Pathway: Alpha6-Beta4 Integrin Signaling Pathway, organism-specific biosystem; Apoptosis, organism-specific biosystem; Apoptotic cleavage of cell adhesionproteins, organism-specific biosystem; Apoptotic cleavage of cellular proteins, organism-specific biosystem; Apoptotic executionphase, organism-specific biosystem; Arrhythmogenic right ventricular cardiomyopathy (ARVC), organism-specific biosystem; Arrhythmogenic right ventricular cardiomyopathy (ARVC), conserved biosystem
• Function: protein binding; protein binding, bridging; structural constituent of cytoskeleton; structural molecule activity