fut1
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  • Official Full Name
  • fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
  • Background
  • The protein encoded by this gene is a Golgi stack membrane protein that is involved in the creation of a precursor of the H antigen, which is required for the final step in the soluble A and B antigen synthesis pathway. This gene is one of two encoding the galactoside 2-L-fucosyltransferase enzyme. Mutations in this gene are a cause of the H-Bombay blood group.
  • Synonyms
  • FUT1; fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group); fucosyltransferase 1 (galactoside 2 alpha L fucosyltransferase) , fucosyltransferase 1 (galactoside 2 alpha L fucosyltransferase, Bombay phenotype included) , H, HSC; g
Cat.#:FUT1-4558HTag:His
Source (Host):E.coliSpecies:Human
Product nameRecombinant Human FUT1 Protein, His-tagged
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Cat.#:FUT1-4557HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human FUT1 Protein, GST-tagged
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Cat.#:FUT1-2411RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat FUT1 Protein
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Cat.#:FUT1-1768RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey FUT1 Protein, His-tagged
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Cat.#:FUT1-6117HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human FUT1 293 Cell Lysate
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Involved Pathway

FUT1 involved in several pathways and played different roles in them. We selected most pathways FUT1 participated on our site, such as Glycosphingolipid biosynthesis - lacto and neolacto series, Glycosphingolipid biosynthesis - globo series, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with FUT1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Glycosphingolipid biosynthesis - lacto and neolacto series
GCNT2; B4GALT3; B4GALT2; FUT9; FUT3; B4GALT1; B3GNT5B; B3GALT5; B3GALT1; ST8SIA1
Glycosphingolipid biosynthesis - globo series
B3GALT5; HEXA; HEXB; FUT9; GBGT1L4; ST3GAL2; FUT1; NAGA; B3GALNT1; FUT9A
Metabolic pathways
PPCS; POLE3; NDUFS5; NT5C1B; ENOPH1; URAD; SUCLG1; HSD17B6; SPRA; RDH8B

Protein Function

FUT1 has several biochemical functions, for example, fucosyltransferase activity, galactoside 2-alpha-L-fucosyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by FUT1 itself. We selected most functions FUT1 had, and list some proteins which have the same functions with FUT1. You can find most of the proteins on our site.
Function
Related Protein
Function fucosyltransferase activity
Related Protein GALNT18A; FUT9D; UGGT1; PIGB; FUT6; GTDC2; FUT7; FUT4; DPY19L4; POC1BL
Function galactoside 2-alpha-L-fucosyltransferase activity
Related Protein FUT2; FUT1

FUT1 Related Articles

Nonaka, M; Fukuda, MN; et al. Determination of Carbohydrate Structure Recognized by Prostate-specific F77 Monoclonal Antibody through Expression Analysis of Glycosyltransferase Genes. JOURNAL OF BIOLOGICAL CHEMISTRY 289:16478-16486(2014).
Aziz, F; Qiu, Y; et al. The Role of Anti-LeY Antibody in the Downregulation of MAPKs/COX-2 Pathway in Gastric Cancer. CURRENT DRUG TARGETS 15:469-476(2014).